Michael Snyder

TL;DR: The results indicate that cellular origin may influence lineage differentiation propensity of human iPSCs; hence, the somatic memory carried by early passage iPSC should be carefully considered before clinical translation.

TL;DR: The incRNA model is used to separate known C. elegans ncRNAs from coding sequences and other genomic elements with a high level of accuracy, find more than 7000 novel ncRNA candidates, and find that they have distinct expression patterns across developmental stages and tend to use novel RNA structural families.

TL;DR: Tiling arrays are expected to become instrumental for the genome-wide identification and characterization of functional elements and combined with computational methods to relate these data and map the complex interactions of transcriptional regulators can provide insight toward a more comprehensive understanding of fundamental molecular and cellular processes.

TL;DR: The novel relationship between BMPR2 dysfunction and reduced expression of endothelial COL4 and EFNA1 may underlie vulnerability to injury in pulmonary arterial hypertension.

TL;DR: Genomic approaches were used to identify biomarkers and candidate drivers for fibrolamellar hepatocellular carcinoma (FL-HCC), a very rare subtype of pediatric liver cancer for which limited therapeutic options exist and highlight the tumorigenic role of gene fusions in the etiology of pediatric solid tumors.