M
Michael Snyder
Researcher at Stanford University
Publications - 938
Citations - 150929
Michael Snyder is an academic researcher from Stanford University. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 169, co-authored 840 publications receiving 130225 citations. Previous affiliations of Michael Snyder include Wyss Institute for Biologically Inspired Engineering & Public Health Research Institute.
Papers
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Journal ArticleDOI
The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation
Daniel S Kim,Viviana I. Risca,David Reynolds,James Chappell,Adam J. Rubin,Namyoung Jung,Laura K. Donohue,Vanessa Lopez-Pajares,Arwa Kathiria,Minyi Shi,Zhixin Zhao,Harsh Deep,Mahfuza Sharmin,Deepti Rao,Shin Lin,Howard Y. Chang,Michael Snyder,William J. Greenleaf,Anshul Kundaje,Paul A. Khavari,Paul A. Khavari +20 more
TL;DR: In this article, a deep learning framework was used to identify 40,103 dynamic CREs associated with 3,609 dynamically expressed genes, and applied an interpretable deep-learning framework to model the cis-regulatory logic of chromatin accessibility.
Journal ArticleDOI
The DART classification of unannotated transcription within the ENCODE regions: Associating transcription with known and novel loci
Joel Rozowsky,Daniel E. Newburger,Fred Sayward,Jia Qian Wu,Greg Jordan,Jan O. Korbel,Ugrappa Nagalakshmi,Jin Yang,Deyou Zheng,Roderic Guigó,Thomas R. Gingeras,Sherman M. Weissman,Perry L. Miller,Michael Snyder,Mark Gerstein +14 more
TL;DR: This work uses a number of disparate features to classify the 6988 novel TARs-array expression profiles across cell lines and conditions, sequence composition, phylogenetic profiles (presence/absence of syntenic conservation across 17 species), and locations relative to genes.
Journal ArticleDOI
Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus.
Vivek Nanda,Ting Wang,Milos Pjanic,Boxiang Liu,Trieu Nguyen,Ljubica Perisic Matic,Ulf Hedin,Simon Koplev,Lijiang Ma,Oscar Franzén,Arno Ruusalepp,Eric E. Schadt,Johan Björkegren,Johan Björkegren,Johan Björkegren,Stephen B. Montgomery,Michael Snyder,Thomas Quertermous,Nicholas J. Leeper,Clint L. Miller,Clint L. Miller +20 more
TL;DR: Functional evidence is provided that genetic variation is associated with dysregulated LMOD1 expression/function in SMCs, together contributing to the heritable risk for CAD.
Journal ArticleDOI
Prospects and Challenges in Proteomics
Paul Bertone,Michael Snyder +1 more
TL;DR: Proteomics is one of the fastest growing areas in areas of research, largely because the global-scale analysis of proteins is expected to yield more direct understanding of function and regulation than analysis of genes.
Book ChapterDOI
ChIP-Seq using high-throughput DNA sequencing for genome-wide identification of transcription factor binding sites.
TL;DR: This chapter describes the yeast ChIP-Seq procedure, including the protocols for ChIP, input DNA preparation, and Illumina DNA sequencing library preparation and describes the use of multiplex short-read sequencing, which enables the analysis of many ChIP samples simultaneously.