M
Michael Snyder
Researcher at Stanford University
Publications - 938
Citations - 150929
Michael Snyder is an academic researcher from Stanford University. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 169, co-authored 840 publications receiving 130225 citations. Previous affiliations of Michael Snyder include Wyss Institute for Biologically Inspired Engineering & Public Health Research Institute.
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Isolation of the gene encoding yeast DNA polymerase I
TL;DR: Gene disruption and Southern hybridization experiments show that the polymerase is encoded by an essential, single copy gene.
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Phased whole-genome genetic risk in a family quartet using a major allele reference sequence.
Frederick E. Dewey,Rong Chen,Sergio Cordero,Kelly E. Ormond,Colleen Caleshu,Konrad J. Karczewski,Michelle Whirl-Carrillo,Matthew T. Wheeler,Joel T. Dudley,Jake K. Byrnes,Omar E. Cornejo,Joshua W. Knowles,Mark Woon,Katrin Sangkuhl,Li Gong,Caroline F. Thorn,Joan M. Hebert,Emidio Capriotti,Sean P. David,Aleksandra Pavlovic,Anne West,Joseph V. Thakuria,Madeleine Ball,Alexander Wait Zaranek,Heidi L. Rehm,George M. Church,John West,Carlos Bustamante,Michael Snyder,Russ B. Altman,Teri E. Klein,Atul J. Butte,Euan A. Ashley +32 more
TL;DR: A novel synthetic human reference sequence is developed that is ethnically concordant and used for the analysis of genomes from a nuclear family with history of familial thrombophilia, demonstrating that the use of the major allele reference sequence results in improved genotype accuracy for disease-associated variant loci.
Journal ArticleDOI
Protein complexes take the bait
Anuj Kumar,Michael Snyder +1 more
TL;DR: In this article, labelled proteins are used as "bait" to capture and identify protein-protein complexes in large-scale studies, which is a technique that has been successfully used to identify proteins that are bound together in complexes.
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Microarrays to characterize protein interactions on a whole-proteome scale.
TL;DR: The ultimate form of a functional protein array consists of all of the proteins encoded by the genome of an organism; such an array would be the whole proteome equivalent of the whole genome DNA arrays that are now available.
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Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers.
Mingxia Gu,Ning-Yi Shao,Silin Sa,Dan Li,Vittavat Termglinchan,Mohamed Ameen,Ioannis Karakikes,Gustavo Sosa,Fabian Grubert,Jae Cheol Lee,Aiqin Cao,Shalina Taylor,Yu Ma,Zhixin Zhao,James Chappell,Rizwan Hamid,Eric D. Austin,Joseph D. Gold,Joseph C. Wu,Michael Snyder,Marlene Rabinovitch +20 more
TL;DR: Comparison of induced pluripotent stem cell-derived endothelial cells from three families with unaffected mutation carriers, FPAH patients, and gender-matched controls identified features of UMC iPSC-ECs related to modifiers of BMPR2 signaling or to differentially expressed genes that could help inform development of future treatment strategies.