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Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

Ayuko Hoshino, +136 more
- 20 Aug 2020 - 
- Vol. 182, Iss: 4, pp 1044
TLDR
EVP proteins can serve as reliable biomarkers for cancer detection and determining cancer type, and a panel of tumor-type-specific EVP proteins in TEs and plasma are defined, which can classify tumors of unknown primary origin.
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This article is published in Cell.The article was published on 2020-08-20 and is currently open access. It has received 565 citations till now. The article focuses on the topics: Extracellular vesicle.

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The matrix in cancer.

TL;DR: This Review touches on many of the facets of matrix biology in solid cancers, including breast, pancreatic and lung cancer, with the aim of highlighting some of the emerging interactions of the matrix and influences that the matrix has on tumour onset, progression and metastatic dissemination, before summarizing the ongoing work in the field aimed at developing therapies to co-target the matrix in cancer and cancer metastasis.
Journal Article

Trp53R172H and kmsg12d cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

TL;DR: In this article, the authors defined the genetic requirements for pancreatic ductal adenocarcinoma (PDA) and targeted concomitant endogenous expression of Trp53 R172H and Kras G12D to reveal the cooperative development of invasive and widely metastatic carcinoma that recapitulates the human disease.
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Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering

TL;DR: The recent advances in EV biology and emerging strategies of EV bioengineering are summarized, and the prospects for clinical translation of bioengineered EVs and the challenges to be overcome are discussed.
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Isolation and characterization of exosomes for cancer research.

TL;DR: Recent advances in various technologies for exosome isolation for cancer research are summarized and the functions of exosomes in regulating tumor metastasis, drug resistance, and immune modulation in the context of cancer development are outlined.
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Exosomes as mediators of intercellular crosstalk in metabolism

TL;DR: Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs).
References
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Journal ArticleDOI

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.

TL;DR: A generic approach to cancer classification based on gene expression monitoring by DNA microarrays is described and applied to human acute leukemias as a test case and suggests a general strategy for discovering and predicting cancer classes for other types of cancer, independent of previous biological knowledge.
Journal ArticleDOI

Probability-based protein identification by searching sequence databases using mass spectrometry data.

TL;DR: A new computer program, Mascot, is presented, which integrates all three types of search for protein identification by searching a sequence database using mass spectrometry data, and the scoring algorithm is probability based.
Journal ArticleDOI

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

TL;DR: This unit describes different approaches for exosome purification from various sources, and discusses methods to evaluate the purity and homogeneity of the purified exosomes preparations.
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Molecular signatures database (MSigDB) 3.0

TL;DR: A new version of the database, MSigDB 3.0, is reported, with over 6700 gene sets, a complete revision of the collection of canonical pathways and experimental signatures from publications, enhanced annotations and upgrades to the web site.
Related Papers (5)

Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Théry, +417 more

Tumour exosome integrins determine organotropic metastasis