Mingbang Wang

TL;DR: MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance.

TL;DR: Results suggest that WGS and thorough bioinformatic analyses for de novo and rare inherited mutations will improve the detection of genetic variants likely to be associated with ASD or its accompanying clinical symptoms.

TL;DR: In this paper, the authors performed whole-genome sequencing (WGS) of 200 ASD parent-child trios and characterized germline and somatic DNMs and found that the majority of germline DNMs (75.6%) originated from the father and these increased significantly with paternal age only (p=4.2×10-10).

TL;DR: A genome-wide association study of Han Chinese with a sample size 2.7 times the largest previously published GWAS on centenarians suggests protective mechanisms including immunity and nutrient metabolism and their interactions with environmental stress play key roles in human longevity.

TL;DR: Glutamate synthase was more active in the guts of patients with schizophrenia than in those of healthy controls, and high GOGAT activity was associated with altered gut microbiota taxonomies associated with gut IgA levels, which may imply a role of the microbiome in the etiology of schizophrenia and contribute to the development of microbiome targeted interventions for schizophrenia.