M
Mingbang Wang
Researcher at Boston Children's Hospital
Publications - 53
Citations - 6782
Mingbang Wang is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Autism & Gut flora. The author has an hindex of 16, co-authored 44 publications receiving 5162 citations. Previous affiliations of Mingbang Wang include Beijing Institute of Genomics & Fudan University.
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Journal ArticleDOI
A metagenome-wide association study of gut microbiota in type 2 diabetes
Junjie Qin,Yingrui Li,Zhiming Cai,Shenghui Li,Jianfeng Zhu,Fan Zhang,Suisha Liang,Wenwei Zhang,Yuanlin Guan,Dongqian Shen,Yangqing Peng,Dongya Zhang,Zhuye Jie,Wenxian Wu,Youwen Qin,Wenbin Xue,Junhua Li,Lingchuan Han,Donghui Lu,Peixian Wu,Yali Dai,Xiaojuan Sun,Zesong Li,Aifa Tang,Shilong Zhong,Xiaoping Li,Weineng Chen,Ran Xu,Mingbang Wang,Qiang Feng,Meihua Gong,Jing Yu,Yanyan Zhang,Ming Zhang,Torben Hansen,Gaston Sanchez,Jeroen Raes,Gwen Falony,Shujiro Okuda,Mathieu Almeida,Emmanuelle Le-chatelier,Pierre Renault,Nicolas Pons,Jean-Michel Batto,Zhaoxi Zhang,Hua Chen,Ruifu Yang,Wei-Mou Zheng,Songgang Li,Huanming Yang,Jian Wang,S. Dusko Ehrlich,Rasmus Nielsen,Oluf Pedersen,Oluf Pedersen,Karsten Kristiansen,Jun Wang +56 more
TL;DR: MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance.
Journal ArticleDOI
Detection of Clinically Relevant Genetic Variants in Autism Spectrum Disorder by Whole-Genome Sequencing
Yong-hui Jiang,Ryan K. C. Yuen,Xin Jin,Xin Jin,Mingbang Wang,Nong Chen,Xueli Wu,Jia Ju,Junpu Mei,Yujian Shi,Mingze He,Guangbiao Wang,Jieqin Liang,Zhe Wang,Dandan Cao,Melissa T. Carter,Christina Chrysler,Irene Drmic,Jennifer L. Howe,Lynette Lau,Christian R. Marshall,Christian R. Marshall,Daniele Merico,Thomas Nalpathamkalam,Bhooma Thiruvahindrapuram,Ann Thompson,Mohammed Uddin,Susan Walker,J. Luo,Evdokia Anagnostou,Lonnie Zwaigenbaum,Robert H. Ring,Jian Wang,Clara Lajonchere,Jun Wang,Andy Shih,Peter Szatmari,Huanming Yang,Geraldine Dawson,Geraldine Dawson,Yingrui Li,Stephen W. Scherer,Stephen W. Scherer +42 more
TL;DR: Results suggest that WGS and thorough bioinformatic analyses for de novo and rare inherited mutations will improve the detection of genetic variants likely to be associated with ASD or its accompanying clinical symptoms.
Journal ArticleDOI
Genome-wide characteristics of de novo mutations in autism
Ryan K. C. Yuen,Daniele Merico,Hongzhi Cao,Giovanna Pellecchia,Babak Alipanahi,Bhooma Thiruvahindrapuram,Xin Tong,Yuhui Sun,Dandan Cao,Tao Zhang,Xueli Wu,Xin Jin,Ze Zhou,Xiaomin Liu,Thomas Nalpathamkalam,Susan Walker,Jennifer L. Howe,Zhuozhi Wang,Jeffrey R. MacDonald,Ada Js Chan,Lia D’Abate,Eric Deneault,Michelle T. Siu,Kristiina Tammimies,Mohammed Uddin,Mehdi Zarrei,Mingbang Wang,Yingrui Li,Jun Wang,Jian Wang,Huanming Yang,Matt Bookman,Jonathan Bingham,Samuel S Gross,Dion Loy,Mathew T. Pletcher,Christian R. Marshall,Evdokia Anagnostou,Lonnie Zwaigenbaum,Rosanna Weksberg,Bridget A. Fernandez,Wendy Roberts,Peter Szatmari,David Glazer,Brendan J. Frey,Robert H. Ring,Xun Xu,Stephen W. Scherer +47 more
TL;DR: In this paper, the authors performed whole-genome sequencing (WGS) of 200 ASD parent-child trios and characterized germline and somatic DNMs and found that the majority of germline DNMs (75.6%) originated from the father and these increased significantly with paternal age only (p=4.2×10-10).
Journal ArticleDOI
Novel loci and pathways significantly associated with longevity
Yi Zeng,Yi Zeng,Chao Nie,Junxia Min,Xiaomin Liu,Mengmeng Li,Huashuai Chen,Huashuai Chen,Hanshi Xu,Mingbang Wang,Ting Ni,Yang Li,Han Yan,Jin Pei Zhang,Chun Song,Li Qing Chi,Han Ming Wang,Jie Dong,Gu Yan Zheng,Li Lin,Feng Qian,Yanwei Qi,Xiao Liu,Hongzhi Cao,Yinghao Wang,Lijuan Zhang,Zhaochun Li,Yufeng Zhou,Yan Wang,Jiehua Lu,Jianxin Li,Ming Qi,Lars Bolund,Anatoliy I. Yashin,Kenneth C. Land,Simon G. Gregory,Ze Yang,William K. Gottschalk,Wei Tao,Jian Wang,Jun Wang,Xun Xu,Harold Bae,Marianne Nygaard,Lene Christiansen,Kaare Christensen,Claudio Franceschi,Michael W. Lutz,Jun Gu,Qihua Tan,Thomas T. Perls,Paola Sebastiani,Joris Deelen,Eline Slagboom,Elizabeth R. Hauser,Huji Xu,Xiao-Li Tian,Huanming Yang,James W. Vaupel +58 more
TL;DR: A genome-wide association study of Han Chinese with a sample size 2.7 times the largest previously published GWAS on centenarians suggests protective mechanisms including immunity and nutrient metabolism and their interactions with environmental stress play key roles in human longevity.
Journal ArticleDOI
Altered gut microbiota and mucosal immunity in patients with schizophrenia.
Ruihuan Xu,Bingbing Wu,Jingwen Liang,Fusheng He,Wen Gu,Kang Li,Yi Luo,Jianxia Chen,Yongbo Gao,Ze Wu,Yongqiang Wang,Wenhao Zhou,Mingbang Wang +12 more
TL;DR: Glutamate synthase was more active in the guts of patients with schizophrenia than in those of healthy controls, and high GOGAT activity was associated with altered gut microbiota taxonomies associated with gut IgA levels, which may imply a role of the microbiome in the etiology of schizophrenia and contribute to the development of microbiome targeted interventions for schizophrenia.