G. Kirov

TL;DR: In this paper, the authors found evidence of some degree of overlap in the biological underpinnings of susceptibility to mental illness across the clinical spectrum of mood and psychotic disorders, and showed that at least some loci can have a relatively general effect on susceptibility to diagnostic categories, as currently defined.

TL;DR: In this article, the authors found a genome-wide significant association between rare loss-of-function (LoF) variants in SETD1A and risk for schizophrenia (P = 3.3 × 10−9).

TL;DR: A meta-analysis of genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome revealed a meaningful structure within the eight disorders identifying three groups of inter-related disorders.

TL;DR: This study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level, and whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.

TL;DR: Observations show that LoF variants in KMT2F cause a range of neurodevelopmental disorders, including schizophrenia, and more generally implicate epigenetic dysregulation, specifically in the histone H3K4 methylation pathway, as an important mechanism in the pathogenesis of schizophrenia.