P
Päivi Hartikainen
Researcher at University of Eastern Finland
Publications - 101
Citations - 5480
Päivi Hartikainen is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Frontotemporal dementia & Frontotemporal lobar degeneration. The author has an hindex of 31, co-authored 91 publications receiving 4923 citations. Previous affiliations of Päivi Hartikainen include Turku University Hospital.
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Journal ArticleDOI
Cerebrospinal Fluid β-Amyloid 42 and Tau Proteins as Biomarkers of Alzheimer-Type Pathologic Changes in the Brain
Tero Tapiola,Irina Alafuzoff,Sanna-Kaisa Herukka,Laura Parkkinen,Päivi Hartikainen,Hilkka Soininen,Tuula Pirttilä +6 more
TL;DR: Cerebrospinal fluid Abeta42 and tau proteins are biomarkers of AD-associated pathologic changes in the brain and the combination of abnormally low CSF Abeta 42 level and abnormally high CSF tau level predicted the presence of AD pathologic features with high accuracy.
Journal ArticleDOI
Presymptomatic hippocampal atrophy in Alzheimer's disease. A longitudinal MRI study.
Nick C. Fox,Elizabeth K. Warrington,P.A. Freeborough,Päivi Hartikainen,A. M. Kennedy,JM Stevens,Martin N. Rossor +6 more
TL;DR: Volumetric measurement of the HF showed that asymmetrical atrophy developed in asymptomatic individuals at risk of autosomal dominant familial Alzheimer's disease before the appearance of symptoms, which may have implications for early diagnosis of Alzheimer’s disease.
Journal ArticleDOI
Hippocampus and entorhinal cortex in mild cognitive impairment and early AD
Corina Pennanen,Miia Kivipelto,Susanna Tuomainen,Päivi Hartikainen,Tuomo Hänninen,Mikko P. Laakso,Merja Hallikainen,Matti Vanhanen,Aulikki Nissinen,Eeva-Liisa Helkala,Pauli Vainio,Ritva Vanninen,Kaarina Partanen,Hilkka Soininen +13 more
TL;DR: The results suggest that the ERC atrophy precedes hippocampal atrophy in AD, and the E RC volume loss is dominant over the hippocampal volume loss in MCI, whereas more pronounced hippocampalVolume loss appears in mild AD.
Journal ArticleDOI
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions
Vivianna M. Van Deerlin,Patrick M. A. Sleiman,Maria Martinez-Lage,Maria Martinez-Lage,Alice Chen-Plotkin,Li-San Wang,Neill R. Graff-Radford,Dennis W. Dickson,Rosa Rademakers,Bradley F. Boeve,Murray Grossman,Steven E. Arnold,David M. A. Mann,Stuart Pickering-Brown,Harro Seelaar,Peter Heutink,John C. van Swieten,Jill R. Murrell,Bernardino Ghetti,Salvatore Spina,Salvatore Spina,Jordan Grafman,John R. Hodges,Maria Grazia Spillantini,Sid Gilman,Andrew P. Lieberman,Jeffrey Kaye,Randall L. Woltjer,Eileen H. Bigio,M.-Marsel Mesulam,Safa Al-Sarraj,Claire Troakes,Roger N. Rosenberg,Charles L. White,Isidro Ferrer,Albert Lladó,Manuela Neumann,Hans A. Kretzschmar,Christine M. Hulette,Kathleen A. Welsh-Bohmer,Bruce L. Miller,Ainhoa Alzualde,Adolfo López de Munain,Ann C. McKee,Ann C. McKee,Marla Gearing,Allan I. Levey,James J. Lah,John Hardy,Jonathan D. Rohrer,Tammaryn Lashley,Ian R. A. Mackenzie,Howard Feldman,Ronald L. Hamilton,Steven T. DeKosky,Julie van der Zee,Julie van der Zee,Samir Kumar-Singh,Samir Kumar-Singh,Christine Van Broeckhoven,Christine Van Broeckhoven,Richard Mayeux,Jean Paul G. Vonsattel,Juan C. Troncoso,Jillian J. Kril,John B.J. Kwok,Glenda M. Halliday,Thomas D. Bird,Paul G. Ince,Pamela J. Shaw,Nigel J. Cairns,John C. Morris,Catriona McLean,Charles DeCarli,William G. Ellis,Stefanie H. Freeman,Matthew P. Frosch,John H. Growdon,Daniel P. Perl,Mary Sano,Mary Sano,David A. Bennett,Julie A. Schneider,Thomas G. Beach,Eric M. Reiman,Bryan K. Woodruff,Jeffrey L. Cummings,Harry V. Vinters,Carol A. Miller,Helena C. Chui,Irina Alafuzoff,Irina Alafuzoff,Päivi Hartikainen,Danielle Seilhean,Douglas Galasko,Eliezer Masliah,Carl W. Cotman,M. Teresa Tũón,M. Cristina Caballero Martínez,David G. Munoz,Steven L. Carroll,Daniel C. Marson,Peter Riederer,Nenad Bogdanovic,Gerard D. Schellenberg,Hakon Hakonarson,John Q. Trojanowski,Virginia M.-Y. Lee +107 more
TL;DR: It is found that FTLD-TDP associates with multiple SNPs mapping to a single linkage disequilibrium block on 7p21 that contains TMEM 106B, which implicate variants in TMEM106B as a strong risk factor for FTLD, suggesting an underlying pathogenic mechanism.
Journal ArticleDOI
Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer's disease: correlation with memory functions.
Mikko P. Laakso,H. Soininen,Kaarina Partanen,Eeva-Liisa Helkala,Päivi Hartikainen,Pauli Vainio,Merja Hallikainen,Tuomo Hänninen,Paavo Riekkinen +8 more
TL;DR: In AD patients the volumes of the left hippocampus correlated significantly with the MMSE score and with immediate and delayed verbal memory; the smaller the volume the more impaired was their performance.