Bryan K. Woodruff

TL;DR: Clinical examination of patients with PGRN mutations revealed highly variable onset ages with language dysfunction as a common presenting symptom, and neuropathological examination showed FTLD with ubiquitin-positive cytoplasmic and intranuclear inclusions in all P GRN mutation carriers.

TL;DR: It is found that FTLD-TDP associates with multiple SNPs mapping to a single linkage disequilibrium block on 7p21 that contains TMEM 106B, which implicate variants in TMEM106B as a strong risk factor for FTLD, suggesting an underlying pathogenic mechanism.

TL;DR: Age-related memory decline in APOE epsilon4 carriers diverges from that of noncarriers before the age of 60 years, despite ongoing normal clinical status, and similar although weaker effects on measures of visuospatial awareness and general mental status are observed.

TL;DR: Until the pathophysiologic mechanism of this and other autoimmune encephalopathies is better characterized, it is believed that descriptive terms that reflect an association rather than causation are most appropriate for this syndrome.

TL;DR: In this large series of PSG-confirmed and probable RBD cases that underwent autopsy, the strong association of RBD with the synucleinopathies was further substantiated and a wider spectrum of disorders which can underlie RBD now are more apparent.