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Open AccessJournal ArticleDOI

Human immune system variation

Petter Brodin, +1 more
- 01 Jan 2017 - 
- Vol. 17, Iss: 1, pp 21-29
TLDR
The human immune system is highly variable between individuals but relatively stable over time within a given person, but symbiotic and pathogenic microbes and other non-heritable influences explain most of this variation.
Abstract: 
The human immune system is highly variable between individuals but relatively stable over time within a given person. Recent conceptual and technological advances have enabled systems immunology analyses, which reveal the composition of immune cells and proteins in populations of healthy individuals. The range of variation and some specific influences that shape an individual's immune system is now becoming clearer. Human immune systems vary as a consequence of heritable and non-heritable influences, but symbiotic and pathogenic microbes and other non-heritable influences explain most of this variation. Understanding when and how such influences shape the human immune system is key for defining metrics of immunological health and understanding the risk of immune-mediated and infectious diseases.

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Citations
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Gut Immune Maturation Depends Upon Colonization with Host-Specific Microbiota

Hachung Chung
TL;DR: In this paper, the authors colonized GF mice with mouse microbiota (MMb) or human microbiota (HMb) to determine whether small intestinal immune maturation depends on a coevolved host-specific microbiota.
Journal ArticleDOI

ImmuCellAI: A Unique Method for Comprehensive T-Cell Subsets Abundance Prediction and its Application in Cancer Immunotherapy.

Ya-Ru Miao, +6 more
- 11 Feb 2020 - 
TL;DR: Application of ImmuCellAI to immunotherapy datasets reveals that the abundance of dendritic cells, cytotoxic T, and gamma delta T cells is significantly higher both in comparisons of on‐treatment versus pre‐treatment and responders versus non‐responders.
Journal ArticleDOI

Stereotypic Immune System Development in Newborn Children

Axel Olin, +13 more
- 23 Aug 2018 - 
TL;DR: This article performed longitudinal analyses in 100 newborn children, sampled up to 4 times during their first 3 months of life, and analyzed the development of 58 immune cell populations by mass cytometry and 267 plasma proteins by immunoassays.
Journal ArticleDOI

Immune Function and Micronutrient Requirements Change over the Life Course

Silvia Maggini, +2 more
- 17 Oct 2018 - 
TL;DR: This review looks at immune considerations specific to each life stage, the consequent risk of infection, micronutrient requirements and deficiencies exhibited over the life course, and the available evidence regarding the effects of micronsutrient supplementation on immune function and infection.
Journal ArticleDOI

Systemic and mucosal antibody responses specific to SARS-CoV-2 during mild versus severe COVID-19

Carlo Cervia, +24 more
- 01 Feb 2021 - 
TL;DR: Systemic antibody production against SARS-CoV-2 develops mainly in severe COVID-19, with very high IgA titers seen in patients with severe ARDS, whereas mild disease may be associated with transient production of SARS-Cov-2-specific antibodies but stimulate mucosal SARs- coV- 2-specific IgA secretion.
References
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Journal ArticleDOI

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Evan Z. Macosko, +26 more
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Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

Evan Z. Macosko, +26 more
TL;DR: Drop-seq as discussed by the authors analyzes mRNA transcripts from thousands of individual cells simultaneously while remembering transcripts' cell of origin, and identifies 39 transcriptionally distinct cell populations, creating a molecular atlas of gene expression for known retinal cell classes and novel candidate cell subtypes.
Journal ArticleDOI

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Journal ArticleDOI

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TL;DR: Comparison of melanoma growth in mice harboring distinct commensal microbiota and observed differences in spontaneous antitumor immunity, suggests that manipulating the microbiota may modulate cancer immunotherapy.
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