S
Sabine Borchard
Publications - 12
Citations - 518
Sabine Borchard is an academic researcher. The author has contributed to research in topics: Copper toxicity & Mitochondrion. The author has an hindex of 8, co-authored 12 publications receiving 300 citations.
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Book ChapterDOI
Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases.
Carlotta Giorgi,Saverio Marchi,Ines C.M. Simoes,Ziyu Ren,Giampaolo Morciano,Mariasole Perrone,Paulina Patalas-Krawczyk,Sabine Borchard,Paulina Jędrak,Karolina Pierzynowska,Jędrzej Szymański,David Q.-H. Wang,Piero Portincasa,Grzegorz Węgrzyn,Hans Zischka,Pawel Dobrzyn,Massimo Bonora,Jerzy Duszyński,Alessandro Rimessi,Agnieszka Karkucinska-Wieckowska,Agnieszka Dobrzyn,Gyorgy Szabadkai,Barbara Zavan,Paulo J. Oliveira,Vilma A. Sardão,Paolo Pinton,Mariusz R. Wieckowski +26 more
TL;DR: An update regarding the key roles of ROS-mitochondria cross talk in different fundamental physiological or pathological situations accompanying aging is provided, highlighting that mitochondrial ROS may be a decisive target in clinical practice.
Journal ArticleDOI
Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis
Elena V. Polishchuk,Assunta Merolla,Josef Lichtmannegger,Alessia Romano,Alessia Indrieri,Ekaterina Y. Ilyechova,Mafalda Concilli,Rossella De Cegli,Roberta Crispino,Marta Mariniello,Raffaella Petruzzelli,Giusy Ranucci,Raffaele Iorio,Federico Pietrocola,Claudia Einer,Sabine Borchard,Andree Zibert,Hartmut Schmidt,Elia Di Schiavi,Ludmila V. Puchkova,Brunella Franco,Guido Kroemer,Hans Zischka,Roman S. Polishchuk +23 more
TL;DR: ATP7B-deficient hepatocytes, such as in those in patients with WD, activate autophagy in response to copper overload to prevent copper-induced apoptosis, and agents designed to activate this autophagic pathway might decrease copper toxicity in Patients with WD.
Journal ArticleDOI
A semi-automated method for isolating functionally intact mitochondria from cultured cells and tissue biopsies
Sabine Schmitt,Friederike Saathoff,Lilja Meissner,Eva-Maria Schropp,Josef Lichtmannegger,Sabine Schulz,Carola Eberhagen,Sabine Borchard,Michaela Aichler,Jerzy Adamski,Nikolaus Plesnila,Simon Rothenfusser,Guido Kroemer,Hans Zischka +13 more
TL;DR: This work presents an efficient method to isolate functionally active, intact mitochondria from cultured or primary cells and minute tissue samples in a rapid, highly reproducible manner.
Journal ArticleDOI
A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease Rats
Claudia Einer,Christin Leitzinger,Josef Lichtmannegger,Carola Eberhagen,Tamara Rieder,Sabine Borchard,Ralf Wimmer,Gerald Denk,Bastian Popper,Frauke Neff,Elena V. Polishchuk,Roman S. Polishchuk,Stefanie M. Hauck,Christine von Toerne,Jennifer-Christin Müller,Uwe Karst,Bipin S. Baral,Alan A. DiSpirito,Andreas E. Kremer,Jeremy D. Semrau,Karl Heinz Weiss,Simon Hohenester,Hans Zischka +22 more
TL;DR: A high-calorie diet severely aggravates hepatic mitochondrial and hepatocellular damage in Wilson disease rats, causing an earlier onset of the disease and enhanced disease progression.
Journal ArticleDOI
Mitochondrial adaptation in steatotic mice.
Claudia Einer,Simon Hohenester,Ralf Wimmer,Lena Wottke,Renate Artmann,Sabine Schulz,Christian Gosmann,Alisha Simmons,Christin Leitzinger,Carola Eberhagen,Sabine Borchard,Sabine Schmitt,Stefanie M. Hauck,Christine von Toerne,Martin Jastroch,Ellen Walheim,Christian Rust,Alexander L. Gerbes,Bastian Popper,Doris Mayr,Max Schnurr,Angelika M. Vollmar,Gerald Denk,Hans Zischka +23 more
TL;DR: WD-mitochondria do not promote steatotic wild type and immune-compromised mice fed a Western diet, but demonstrate bioenergetic deficits and increased sensitivity to stress signals.