T
Thomas Werge
Researcher at University of Copenhagen
Publications - 498
Citations - 51965
Thomas Werge is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 77, co-authored 420 publications receiving 39165 citations. Previous affiliations of Thomas Werge include Mental Health Services & SUNY Downstate Medical Center.
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Journal ArticleDOI
Genome-wide association study implicates CHRNA2 in cannabis use disorder.
Ditte Demontis,Ditte Demontis,Veera M. Rajagopal,Veera M. Rajagopal,Thorgeir E. Thorgeirsson,Thomas Damm Als,Thomas Damm Als,Jakob Grove,Kalle Leppälä,Kalle Leppälä,Daniel F. Gudbjartsson,Jonatan Pallesen,Jonatan Pallesen,Carsten Hjorthøj,Carsten Hjorthøj,Gunnar W Reginsson,Thorarinn Tyrfingsson,Valgerdur Runarsdottir,Per Qvist,Per Qvist,Jane H. Christensen,Jane H. Christensen,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,Marie Bækvad-Hansen,Marie Bækvad-Hansen,Laura M. Huckins,Eli A. Stahl,Allan Timmermann,Esben Agerbo,Esben Agerbo,David M. Hougaard,David M. Hougaard,Thomas Werge,Thomas Werge,Thomas Werge,Ole Mors,Ole Mors,Preben Bo Mortensen,Preben Bo Mortensen,Merete Nordentoft,Merete Nordentoft,Merete Nordentoft,Mark J. Daly,Mark J. Daly,Hreinn Stefansson,Kari Stefansson,Mette Nyegaard,Mette Nyegaard,Anders D. Børglum,Anders D. Børglum +50 more
TL;DR: The study reports a genome-wide significant locus for cannabis use disorder, replicating in an independent cohort, and implicates CHRNA2, which encodes an acetylcholine receptor subunit, in the disorder by analyses of genetically regulated gene expression.
Journal ArticleDOI
Genetic Markers of Human Evolution Are Enriched in Schizophrenia
Saurabh Srinivasan,Saurabh Srinivasan,Francesco Bettella,Francesco Bettella,Morten Mattingsdal,Morten Mattingsdal,Yunpeng Wang,Yunpeng Wang,Yunpeng Wang,Aree Witoelar,Aree Witoelar,Andrew J. Schork,Wesley K. Thompson,Verena Zuber,Verena Zuber,Bendik S. Winsvold,Bendik S. Winsvold,John-Anker Zwart,John-Anker Zwart,David A. Collier,Rahul S. Desikan,Rahul S. Desikan,Ingrid Melle,Ingrid Melle,Thomas Werge,Thomas Werge,Thomas Werge,Anders M. Dale,Srdjan Djurovic,Srdjan Djurovic,Ole A. Andreassen,Ole A. Andreassen,Ole A. Andreassen +32 more
TL;DR: There is a polygenic overlap between schizophrenia and NSS score, a marker of human evolution, which is in line with the hypothesis that the persistence of schizophrenia is related to the evolutionary process of becoming human.
Journal ArticleDOI
A Mouse Model that Recapitulates Cardinal Features of the 15q13.3 Microdeletion Syndrome Including Schizophrenia- and Epilepsy-Related Alterations
Kim Fejgin,Jacob Nielsen,Michelle Rosgaard Birknow,Jesper F. Bastlund,Vibeke Nielsen,Jes B. Lauridsen,Hreinn Stefansson,Stacy Steinberg,Helge Bjarup Dissing Sørensen,Troels E. Mortensen,Peter H. Larsen,Ib Vestergaard Klewe,Søren V. Rasmussen,Kari Stefansson,Thomas Werge,Pekka Kallunki,Kenneth Vielsted Christensen,Michael Didriksen +17 more
TL;DR: The Df(h15q13)/+ mouse shows similarities to several alterations related to the 15q13.3 microdeletion syndrome, epilepsy, and schizophrenia, offering a novel tool for addressing the underlying biology of these diseases.
Journal ArticleDOI
Population genomics of the Viking world
Ashot Margaryan,Ashot Margaryan,Daniel Lawson,Martin Sikora,Fernando Racimo,Simon Rasmussen,Ida Moltke,Lara M. Cassidy,Emil Jørsboe,Andres Ingason,Andres Ingason,Mikkel Winther Pedersen,Thorfinn Sand Korneliussen,Thorfinn Sand Korneliussen,Helene Wilhelmson,Magdalena M. Buś,Peter de Barros Damgaard,Rui Martiniano,Gabriel Renaud,Gabriel Renaud,Claude Bhérer,J. Víctor Moreno-Mayar,Anna K. Fotakis,Marie Allen,Raili Allmäe,Martyna Molak,Enrico Cappellini,Gabriele Scorrano,Hugh McColl,Alexandra P. Buzhilova,Allison M. Fox,Anders Albrechtsen,Berit Schütz,Birgitte Skar,Caroline Arcini,Ceri Falys,Charlotte Hedenstierna Jonson,Dariusz Błaszczyk,Denis Pezhemsky,Gordon Turner-Walker,Hildur Gestsdóttir,Inge Lundstrøm,Ingrid Gustin,Ingrid Mainland,Inna Potekhina,Italo M. Muntoni,Jade Cheng,Jesper Stenderup,Jilong Ma,Julie Gibson,Jüri Peets,Jörgen Gustafsson,Katrine Højholt Iversen,Katrine Højholt Iversen,Linzi Simpson,Lisa Strand,Louise Loe,Maeve Sikora,Marek Florek,Maria Vretemark,Mark Redknap,Monika Bajka,Tamara Pushkina,Morten Søvsø,Natalia Grigoreva,Tom Christensen,Ole Kastholm,Otto Uldum,Pasquale Favia,Per Holck,Sabine Sten,Símun V. Arge,Sturla Ellingvåg,Vayacheslav Moiseyev,Wiesław Bogdanowicz,Yvonne Magnusson,Ludovic Orlando,Peter Pentz,Mads Dengsø Jessen,Anne Pedersen,Mark Collard,Daniel G. Bradley,Marie Louise Jørkov,Jette Arneborg,Niels Lynnerup,Neil Price,M. Thomas P. Gilbert,M. Thomas P. Gilbert,Morten E. Allentoft,Morten E. Allentoft,Jan Bill,Søren M. Sindbæk,Lotte Hedeager,Kristian Kristiansen,Rasmus Nielsen,Rasmus Nielsen,Thomas Werge,Eske Willerslev +97 more
TL;DR: It is concluded that the Viking diaspora was characterized by substantial transregional engagement: distinct populations influenced the genomic makeup of different regions of Europe, and Scandinavia experienced increased contact with the rest of the continent.
Journal ArticleDOI
Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum
Andrea Ganna,F. Kyle Satterstrom,F. Kyle Satterstrom,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Indraniel Das,Indraniel Das,Mitja I. Kurki,Mitja I. Kurki,Mitja I. Kurki,Claire Churchhouse,Claire Churchhouse,Jessica Alföldi,Jessica Alföldi,Alicia R. Martin,Alicia R. Martin,Aki S. Havulinna,Aki S. Havulinna,Andrea Byrnes,Andrea Byrnes,Wesley K. Thompson,Philip R. Nielsen,Philip R. Nielsen,Konrad J. Karczewski,Konrad J. Karczewski,Elmo Saarentaus,Manuel A. Rivas,Namrata Gupta,Olli Pietilainen,Olli Pietilainen,Connor A. Emdin,Francesco Lescai,Francesco Lescai,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,Jason Flannick,Jason Flannick,Josep M. Mercader,Josep M. Mercader,Miriam S. Udler,Miriam S. Udler,Markku Laakso,Veikko Salomaa,Christina M. Hultman,Samuli Ripatti,Samuli Ripatti,Eija Hämäläinen,Jukka S. Moilanen,Jarmo Körkkö,Outi Kuismin,Merete Nordentoft,Merete Nordentoft,David M. Hougaard,David M. Hougaard,Ole Mors,Ole Mors,Thomas Werge,Thomas Werge,Thomas Werge,Preben Bo Mortensen,Daniel G. MacArthur,Daniel G. MacArthur,Mark J. Daly,Mark J. Daly,Patrick Sullivan,Patrick Sullivan,Adam E. Locke,Adam E. Locke,Aarno Palotie,Anders D. Børglum,Anders D. Børglum,Sekar Kathiresan,Sekar Kathiresan,Benjamin M. Neale,Benjamin M. Neale +74 more
TL;DR: A thorough investigation of the impact of rare deleterious coding variants on complex traits, suggesting widespread pleiotropic risk is provided.