T
Tian Lin
Researcher at University of Queensland
Publications - 29
Citations - 1481
Tian Lin is an academic researcher from University of Queensland. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 13, co-authored 26 publications receiving 660 citations. Previous affiliations of Tian Lin include Iowa State University.
Papers
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Journal ArticleDOI
From Basic Science to Clinical Application of Polygenic Risk Scores: A Primer.
Naomi R. Wray,Tian Lin,Jehannine Austin,John J. McGrath,Ian B. Hickie,Graham K. Murray,Graham K. Murray,Graham K. Murray,Peter M. Visscher +8 more
TL;DR: The underlying basic science ofPRS is reviewed, providing a foundation for understanding the potential clinical utility and limitations of PRS, and suggests that in principle, PRS could contribute to treatment choices, but more data are needed to allow development in this context.
Journal ArticleDOI
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing
Qian Zhang,Costanza L. Vallerga,Rosie M. Walker,Tian Lin,Anjali K. Henders,Grant W. Montgomery,Ji He,Dongsheng Fan,Javed Fowdar,Martin A. Kennedy,Toni L. Pitcher,John F. Pearson,Glenda M. Halliday,John B.J. Kwok,Ian B. Hickie,Simon J.G. Lewis,Tim J. Anderson,Peter A. Silburn,George D. Mellick,Sarah E. Harris,Paul Redmond,Alison D. Murray,David J. Porteous,Chris Haley,Kathryn L. Evans,Andrew M. McIntosh,Andrew M. McIntosh,Jian Yang,Jacob Gratten,Riccardo E. Marioni,Naomi R. Wray,Ian J. Deary,Allan F. McRae,Peter M. Visscher +33 more
TL;DR: This study indicates that the epigenetic clock can be improved by increasing the training sample size and that its association with mortality attenuates with increased prediction of chronological age.
Journal ArticleDOI
Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.
Joana A. Revez,Tian Lin,Zhen Qiao,Angli Xue,Yan Holtz,Zhihong Zhu,Jian Zeng,Huanwei Wang,Julia Sidorenko,Kathryn E. Kemper,Anna A. E. Vinkhuyzen,Julanne Frater,Darryl W. Eyles,Darryl W. Eyles,Thomas H. J. Burne,Thomas H. J. Burne,Brittany L. Mitchell,Brittany L. Mitchell,Nicholas G. Martin,Gu Zhu,Peter M. Visscher,Jian Yang,Jian Yang,Naomi R. Wray,John J. McGrath,John J. McGrath,John J. McGrath +26 more
TL;DR: A genome-wide association study of 25 hydroxyvitamin D concentration in 417,580 Europeans identifies 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD.
Journal ArticleDOI
Could Polygenic Risk Scores Be Useful in Psychiatry?: A Review.
Graham K. Murray,Graham K. Murray,Tian Lin,Jehannine Austin,John J. McGrath,John J. McGrath,John J. McGrath,Ian B. Hickie,Naomi R. Wray +8 more
TL;DR: The utility of PRS in clinical psychiatry, as well as ethical issues associated with their use, should be evaluated in the context of realistic expectations of what PRS can and cannot deliver.
Posted ContentDOI
Genomic and phenomic insights from an atlas of genetic effects on DNA methylation
Josine L. Min,Gibran Hemani,Eilis Hannon,Koen F. Dekkers,Juan E. Castillo-Fernandez,René Luijk,Elena Carnero-Montoro,Elena Carnero-Montoro,Daniel Lawson,Kimberley Burrows,Matthew Suderman,Andrew D. Bretherick,Tom G. Richardson,Johanna Klughammer,Valentina Iotchkova,Gemma C Sharp,Ahmad Al Khleifat,Aleksey Shatunov,Alfredo Iacoangeli,Wendy L. McArdle,Karen M Ho,Ashok Kumar,Ashok Kumar,Ashok Kumar,Cilla Söderhäll,Carolina Soriano-Tárraga,Eva Giralt-Steinhauer,Nabila Kazmi,Dan Mason,Allan F. McRae,David L. Corcoran,Karen Sugden,Silva Kasela,Alexia Cardona,Felix R. Day,Giovanni Cugliari,Clara Viberti,Simonetta Guarrera,Michael Lerro,Richa Gupta,Sailalitha Bollepalli,Pooja R. Mandaviya,Yanni Zeng,Yanni Zeng,Toni-Kim Clarke,Rosie M. Walker,Rosie M. Walker,Vanessa Schmoll,Darina Czamara,Carlos Ruiz-Arenas,Faisal I. Rezwan,Riccardo E. Marioni,Tian Lin,Yvonne Awaloff,Marine Germain,Dylan Aïssi,Ramona A. J. Zwamborn,Kristel R. van Eijk,Annelot M. Dekker,Jenny van Dongen,Jouke-Jan Hottenga,Gonneke Willemsen,Cheng-Jian Xu,Guillermo Barturen,Francesc Català-Moll,Martin Kerick,Carol A. Wang,Phillip E. Melton,Hannah R Elliott,Jean Shin,Manon Bernard,Idil Yet,Melissa C. Smart,T.J. Gorrie-Stone,Christopher Shaw,Ammar Al Chalabi,Ammar Al Chalabi,Susan M. Ring,Göran Pershagen,Erik Melén,Jordi Jimenez-Conde,Jaume Roquer,Debbie A Lawlor,John Wright,Nicholas G. Martin,Grant W. Montgomery,Terrie E. Moffitt,Richie Poulton,Tõnu Esko,Tõnu Esko,Lili Milani,Andres Metspalu,John R. B. Perry,Ken K. Ong,Nicholas J. Wareham,Giuseppe Matullo,Carlotta Sacerdote,Avshalom Caspi,Louise Arseneault,Miina Ollikainen,Jaakko Kaprio,Janine F. Felix,Fernando Rivadeneira,Henning Tiemeier,Henning Tiemeier,Marinus H. van IJzendoorn,Marinus H. van IJzendoorn,André G. Uitterlinden,Vincent W. V. Jaddoe,Vincent W. V. Jaddoe,Chris Haley,Andrew M. McIntosh,Andrew M. McIntosh,Kathryn L. Evans,Kathryn L. Evans,Alison D. Murray,Katri Räikkönen,Jari Lahti,Ellen A. Nohr,Ellen A. Nohr,Thorkild I. A. Sørensen,Torben Hansen,Camilla Schmidt Morgen,Elisabeth B. Binder,Elisabeth B. Binder,Susanne Lucae,Juan R. González,Mariona Bustamante,Jordi Sunyer,John W. Holloway,Wilfried Karmaus,Hongmei Zhang,Ian J. Deary,Naomi R. Wray,John M. Starr,Marian Beekman,Diana van Heemst,P. Eline Slagboom,Pierre-Emmanuel Morange,David-Alexandre Trégouët,Jan H. Veldink,Gareth E. Davies,Eco J. C. de Geus,Dorret I. Boomsma,Judith M. Vonk,Bert Brunekreef,Gerard H. Koppelman,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Rae-Chi Huang,Craig E. Pennell,Joyce B. J. van Meurs,M. Arfan Ikram,Alun D. Hughes,Therese Tillin,Nish Chaturvedi,Zdenka Pausova,Tomáš Paus,Tim D. Spector,Meena Kumari,Leonard C. Schalkwyk,Peter M. Visscher,George Davey Smith,Christoph Bock,Tom R. Gaunt,Jordana T. Bell,Bastiaan T. Heijmans,Jonathan Mill,Caroline L Relton +168 more
TL;DR: Results of DNA methylation-quantitative trait loci (mQTL) analyses on 32,851 participants reveal that the genetic architecture of DNAm levels is highly polygenic and DNAm exhibits signatures of negative and positive natural selection.