T
Tomoko Nakanishi
Researcher at McGill University
Publications - 37
Citations - 788
Tomoko Nakanishi is an academic researcher from McGill University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 18 publications receiving 168 citations. Previous affiliations of Tomoko Nakanishi include Kyoto University.
Papers
More filters
Journal ArticleDOI
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
Sirui Zhou,Guillaume Butler-Laporte,Tomoko Nakanishi,David R. Morrison,Jonathan Afilalo,Marc Afilalo,Laetitia Laurent,Maik Pietzner,Nicola D. Kerrison,Kaiqiong Zhao,Elsa Brunet-Ratnasingham,Danielle Henry,Nofar Kimchi,Zaman Afrasiabi,Nardin Rezk,Meriem Bouab,Louis Petitjean,Charlotte Guzman,Xiaoqing Xue,Chris Tselios,Branka Vulesevic,Olumide Adeleye,Tala Abdullah,Noor Almamlouk,Yiheng Chen,Michaël Chassé,Madeleine Durand,Clare Paterson,Johan Normark,Robert Frithiof,Miklos Lipcsey,Michael Hultström,Celia M. T. Greenwood,Hugo Zeberg,Claudia Langenberg,Claudia Langenberg,Elin Thysell,Michael Pollak,Vincent Mooser,Vincenzo Forgetta,Daniel Kaufmann,J. Brent Richards +41 more
TL;DR: In this article, a two-sample Mendelian randomization (MR) study was conducted to identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding.
Journal ArticleDOI
Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study
Guillaume Butler-Laporte,Tomoko Nakanishi,Vincent Mooser,David R. Morrison,Tala Abdullah,Olumide Adeleye,Noor Mamlouk,Nofar Kimchi,Nofar Kimchi,Zaman Afrasiabi,Nardin Rezk,Annarita Giliberti,Alessandra Renieri,Yiheng Chen,Sirui Zhou,Vincenzo Forgetta,J. Brent Richards +16 more
TL;DR: In this paper, a 2-sample Mendelian randomization (MR) was used to assess evidence supporting a causal effect of circulating 25-hydroxy vitamin D (25OHD) levels on COVID-19 susceptibility and severity.
Journal ArticleDOI
Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19
Jennifer E. Huffman,Guillaume Butler-Laporte,Atlas Khan,Erola Pairo-Castineira,Theodore G. Drivas,Gina M. Peloso,Tomoko Nakanishi,Andrea Ganna,Anurag Verma,J Kenneth Baillie,Krzysztof Kiryluk,J. Brent Richards,Hugo Zeberg +12 more
TL;DR: In this paper , the OAS1/2/3 cluster was identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13.
Journal ArticleDOI
Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals
Jack A. Kosmicki,Julie E. Horowitz,Nilanjana Banerjee,Rouel Lanche,Anthony Marcketta,Evan Maxwell,Xiaodong Bai,Dylan Sun,Joshua D. Backman,Deepika Sharma,F. S. P. Kury,Hyun Min Kang,Colm O'Dushlaine,Ashish Yadav,Adam J. Mansfield,Alexander H. Li,Kyoko Watanabe,Lauren Gurski,Shane McCarthy,Adam E. Locke,Shareef Khalid,Sean O'Keeffe,Joelle Mbatchou,Olympe Chazara,Yunfeng Huang,Erika Kvikstad,A. O'Neill,Paul Nioi,Margaret M. Parker,Slavé Petrovski,Heiko Runz,Joseph D. Szustakowski,Quanli Wang,Emily Wong,A. Cordova-Palomera,E. N. Smith,Sándor Szalma,Xiuwen Zheng,Sahar Esmaeeli,Justin W. Davis,Yi-Pin Lai,Xing Chen,Anne E. Justice,Joseph B. Leader,Tooraj Mirshahi,David J. Carey,Anurag Verma,Giorgio Sirugo,Marylyn D. Ritchie,Daniel J. Rader,Gundula Povysil,David Goldstein,Krzysztof Kiryluk,Erola Pairo-Castineira,Konrad Rawlik,Dorota Pasko,Susan P. Walker,Alison M. Meynert,Athanasios Kousathanas,Loukas Moutsianas,Albert Tenesa,Mark J. Caulfield,Richard H Scott,James F. Wilson,J. K. Baillie,Guillaume Butler-Laporte,Tomoko Nakanishi,Mark Lathrop,J. B. Richards,Martin I. Jones,Suganthi Balasubramanian,Will Salerno,A. R. Shuldiner,Jonathan Marchini,John D. Overton,Lukas Habegger,Michael N. Cantor,Jeffrey G. Reid,A. Baras,Gonçalo R. Abecasis,Manuel A. R. Ferreira +80 more
TL;DR: In this article, the authors used exome sequence data to investigate associations between rare genetic variants and seven COVID-19 outcomes in 586,157 individuals, including 20,952 with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a respiratory illness causing hospitalization or death.
Journal ArticleDOI
Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19
Gundula Povysil,Guillaume Butler-Laporte,Ning Shang,Chen Wang,Atlas Khan,Manal Alaamery,Tomoko Nakanishi,Sirui Zhou,Vincenzo Forgetta,Robert Eveleigh,Mathieu Bourgey,Naveed Aziz,Steven J.M. Jones,Bartha Maria Knoppers,Stephen W. Scherer,Lisa J. Strug,Pierre Lepage,Jiannis Ragoussis,Guillaume Bourque,Jahad Alghamdi,Nora Aljawini,Nour Albes,Hani M. Al-Afghani,Bader Alghamdi,Mansour S Almutairi,Ebrahim Mahmoud,Leen Abu-Safieh,Hadeel El Bardisy,Fawz S. Al Harthi,Abdulraheem Alshareef,Bandar A. Suliman,Saleh A. Alqahtani,Abdulaziz Almalik,May Alrashed,Salam Massadeh,Vincent Mooser,Mark Lathrop,Mohamed Fawzy,Yaseen M. Arabi,Hamdi Mbarek,Chadi Saad,Wadha Al-Muftah,Junghyun Jung,Serghei Mangul,Radja Badji,Asma Al Thani,Said I. Ismail,Ali G. Gharavi,Malak Abedalthagafi,J. Brent Richards,David Goldstein,Krzysztof Kiryluk +51 more
TL;DR: In this article, rare predicted loss-of-function (pLOF) variants across 13 candidate genes in TLR3- and IRF7-dependent type I IFN pathways explain up to 3.5% of severe COVID-19 cases.