W
W. Hayes McDonald
Researcher at Vanderbilt University
Publications - 116
Citations - 12031
W. Hayes McDonald is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Gene & Proteome. The author has an hindex of 51, co-authored 110 publications receiving 11219 citations. Previous affiliations of W. Hayes McDonald include Howard Hughes Medical Institute & University of British Columbia.
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Journal ArticleDOI
Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26S Proteasome
Rati Verma,L. Aravind,Robert S. Oania,W. Hayes McDonald,John R. Yates,Eugene V. Koonin,Raymond J. Deshaies +6 more
TL;DR: These findings reveal an unexpected coupling between substrate deubiquitination and degradation and suggest a unifying rationale for the presence of the lid in eukaryotic proteasomes.
Journal ArticleDOI
Phytophthora Genome Sequences Uncover Evolutionary Origins and Mechanisms of Pathogenesis
Brett M. Tyler,Sucheta Tripathy,Xuemin Zhang,Paramvir S. Dehal,Paramvir S. Dehal,Rays H. Y. Jiang,Rays H. Y. Jiang,Andrea Aerts,Andrea Aerts,Felipe D. Arredondo,Laura Baxter,Douda Bensasson,Douda Bensasson,Douda Bensasson,Jim Beynon,Jarrod Chapman,Jarrod Chapman,Jarrod Chapman,C. M. B. Damasceno,Anne E. Dorrance,Daolong Dou,Allan W. Dickerman,Inna Dubchak,Inna Dubchak,Matteo Garbelotto,Mark Gijzen,Stuart G. Gordon,Francine Govers,Niklaus J. Grünwald,Wayne Huang,Wayne Huang,Kelly Ivors,Kelly Ivors,Richard W. Jones,Sophien Kamoun,Konstantinos Krampis,Kurt Lamour,Mi-Kyung Lee,W. Hayes McDonald,MoÌnica Medina,Harold J. G. Meijer,Eric K. Nordberg,Donald J. Maclean,Manuel D. Ospina-Giraldo,Paul Morris,Vipaporn Phuntumart,Nicholas H. Putnam,Nicholas H. Putnam,Sam Rash,Sam Rash,Jocelyn K. C. Rose,Yasuko Sakihama,Asaf Salamov,Asaf Salamov,Alon Savidor,Chantel F. Scheuring,Brian M. Smith,Bruno W. S. Sobral,Astrid Terry,Astrid Terry,Trudy Torto-Alalibo,Joe Win,Zhanyou Xu,Hong-Bin Zhang,Igor V. Grigoriev,Igor V. Grigoriev,Daniel S. Rokhsar,Daniel S. Rokhsar,Jeffrey L. Boore +68 more
TL;DR: Comparison of the two species' genomes reveals a rapid expansion and diversification of many protein families associated with plant infection such as hydrolases, ABC transporters, protein toxins, proteinase inhibitors, and, in particular, a superfamily of 700 proteins with similarity to known oömycete avirulence genes.
Journal ArticleDOI
Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress
Randa Tao,Mitchell C. Coleman,J. Daniel Pennington,Özkan Özden,Seong Hoon Park,Haiyan Jiang,Hyun Seok Kim,Charles R. Flynn,Salisha Hill,W. Hayes McDonald,Alicia K. Olivier,Douglas R. Spitz,David Gius +12 more
TL;DR: Infestation of Sirt3⁻/⁻ MEFs with lenti-MnSOD(K122-R) inhibited in vitro immortalization by an oncogene (Ras), inhibited IR-induced genomic instability, and decreased mitochondrial superoxide, suggesting acetylation directly regulates function.
Journal ArticleDOI
Shotgun identification of protein modifications from protein complexes and lens tissue
Michael J. MacCoss,W. Hayes McDonald,Anita Saraf,Rovshan G. Sadygov,Judy M. Clark,Joseph J. Tasto,Kathleen L. Gould,Dirk Wolters,Michael P. Washburn,Avery H. Weiss,John I. Clark,John R. Yates +11 more
TL;DR: This work describes a process for the analysis of posttranslational modifications that is simple, robust, general, and can be applied to complicated protein mixtures and lens tissue from a patient with congenital cataracts.
Journal ArticleDOI
Mus81-Eme1 Are Essential Components of a Holliday Junction Resolvase
Michael N. Boddy,Pierre-Henri L. Gaillard,W. Hayes McDonald,Paul Shanahan,John R. Yates,Paul Russell +5 more
TL;DR: It is reported that Mus81 and an associated protein Eme1 are components of an endonuclease that resolves Holliday junctions into linear duplex products and constitute strong evidence that Mus 81 and Eme 1 are subunits of a nuclear Holliday junction resolvase.