Y
Yutaka Suzuki
Researcher at University of Tokyo
Publications - 875
Citations - 42146
Yutaka Suzuki is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 85, co-authored 767 publications receiving 35471 citations. Previous affiliations of Yutaka Suzuki include Japan Agency for Medical Research and Development & Institute for the Physics and Mathematics of the Universe.
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Journal ArticleDOI
H-DBAS: Alternative splicing database of completely sequenced and manually annotated full-length cDNAs based on H-Invitational
Jun-ichi Takeda,Yutaka Suzuki,Mitsuteru Nakao,Tsuyoshi Kuroda,Sumio Sugano,Takashi Gojobori,Takashi Gojobori,Tadashi Imanishi,Tadashi Imanishi +8 more
TL;DR: Each AS event can be analyzed in the context of full-length cDNAs, enabling the user's empirical understanding of the relation between AS event and the consequent alternations in the encoded amino acid sequences together with various kinds of affected protein motifs.
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Oncofetal protein IGF2BP3 facilitates the activity of proto-oncogene protein eIF4E through the destabilization of EIF4E-BP2 mRNA.
Rena Mizutani,Naoto Imamachi,Yutaka Suzuki,H Yoshida,Naobumi Tochigi,Tadahiro Oonishi,Nobuyoshi Akimitsu +6 more
TL;DR: It is suggested that IGF2BP3 promotes eIF4E-mediated translational activation through the reduction of EIF 4E-BP2 via mRNA degradation, leading to enhanced cell proliferation, in the first report demonstrating that IGF 2BP3 is an RNA-destabilizing factor.
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Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal antibody treatment in patients with pretreated metastatic colorectal cancer: the Biomarker Research for anti-EGFR monoclonal Antibodies by Comprehensive Cancer genomics (BREAC) study
Eiji Shinozaki,Takayuki Yoshino,Kentaro Yamazaki,Kei Muro,Kensei Yamaguchi,Tomohiro Nishina,Satoshi Yuki,Kohei Shitara,Hideaki Bando,Sachiyo Mimaki,Chikako Nakai,Koutatsu Matsushima,Yutaka Suzuki,Kiwamu Akagi,Takeharu Yamanaka,Shogo Nomura,Satoshi Fujii,Hiroyasu Esumi,Masaya Sugiyama,Nao Nishida,Masashi Mizokami,Yasuhiro Koh,Yukiko Abe,Atsushi Ohtsu,Katsuya Tsuchihara +24 more
TL;DR: Although BRAFnon-V600E mutations identified were a rare and unestablished molecular subtype, certain BRAF non-V 600E mutations might contribute to a lesser benefit of anti-EGFR monoclonal antibody treatment.
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Genome-wide genetic variations are highly correlated with proximal DNA methylation patterns
Wei Qu,Shin-ichi Hashimoto,Atsuko Shimada,Yoichiro Nakatani,Kazuki Ichikawa,Taro Saito,Katsumi Ogoshi,Kouji Matsushima,Yutaka Suzuki,Sumio Sugano,Hiroyuki Takeda,Shinichi Morishita +11 more
TL;DR: An unexpected genome-wide role is identified of the CpG methylation state as a major determinant of proximal natural genetic variation and of the characteristics of evolutionary change in neighboring DNA.
Journal ArticleDOI
High-resolution analysis of the 5'-end transcriptome using a next generation DNA sequencer.
Shin-ichi Hashimoto,Wei Qu,Budrul Ahsan,Katsumi Ogoshi,Atsushi Sasaki,Yoichiro Nakatani,Yongjun Lee,Masako Ogawa,Akio Ametani,Yutaka Suzuki,Sumio Sugano,Clarence Lee,Robert C. Nutter,Shinichi Morishita,Kouji Matsushima +14 more
TL;DR: The development of a 5′–end transcriptome workflow for the SOLiD system is described and the advantages in sensitivity and dynamic range offered by this tag-based application over traditional approaches for the study of whole genome gene expression are demonstrated.