Y
Yutaka Suzuki
Researcher at University of Tokyo
Publications - 875
Citations - 42146
Yutaka Suzuki is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 85, co-authored 767 publications receiving 35471 citations. Previous affiliations of Yutaka Suzuki include Japan Agency for Medical Research and Development & Institute for the Physics and Mathematics of the Universe.
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Journal ArticleDOI
DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis.
Naoki Kubo,Hidehiro Toh,Kenjiro Shirane,Takayuki Shirakawa,Hisato Kobayashi,Tetsuya Sato,Hidetoshi Sone,Yasuyuki Sato,Shin-ichi Tomizawa,Yoshinori Tsurusaki,Hiroki Shibata,Hirotomo Saitsu,Yutaka Suzuki,Naomichi Matsumoto,Mikita Suyama,Tomohiro Kono,Kazuyuki Ohbo,Hiroyuki Sasaki +17 more
TL;DR: A distinctive and dynamic regulation of DNA methylation during spermatogonial stem cell formation and differentiation in the neonatal and early postnatal testes is shown and represents a unique phase of male germ cell development.
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Identification of the carotenoid modifying gene PALE YELLOW PETAL 1 as an essential factor in xanthophyll esterification and yellow flower pigmentation in tomato (Solanum lycopersicum)
Tohru Ariizumi,Sanae Kishimoto,Ryo Kakami,Takashi Maoka,Hideki Hirakawa,Yutaka Suzuki,Yuko Ozeki,Kenta Shirasawa,Stéphane Bernillon,Yoshihiro Okabe,Annick Moing,Erika Asamizu,Christophe Rothan,Akemi Ohmiya,Hiroshi Ezura +14 more
TL;DR: This study characterized two allelic tomato mutants, pale yellow petal (pyp) 1-1 and pyp1-2, that have reduced yellow color intensity in the petals and anthers due to loss-of-function mutations and provided insight into the molecular mechanism underlying the production of xanthophyll esters in higher plants, thereby shedding light on a longstanding mystery.
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Genome-wide analysis reveals strong correlation between CpG islands with nearby transcription start sites of genes and their tissue specificity.
TL;DR: It is found that there is a clear peak in the distribution of CpG islands around TSS in the genes of these two species and the tendency that a gene lacking Cpg islands around its TSS is expressed with a higher degree of tissue specificity turned out to be evolutionarily conserved.
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Direct binding of Ataxin-2 to distinct elements in 3' UTRs promotes mRNA stability and protein expression.
TL;DR: The findings suggest that Ataxin-2 is an RNA-binding protein that targets cis-regulatory elements in 3' UTRs to stabilize a subset of mRNAs and increase protein expression.
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Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines
Ayako Suzuki,Hideki Makinoshima,Hiroyuki Wakaguri,Hiroyasu Esumi,Sumio Sugano,Takashi Kohno,Katsuya Tsuchihara,Yutaka Suzuki +7 more
TL;DR: An integrative multi-omics analysis to understand how cancers harbor various types of aberrations at the genomic, epigenomic and transcriptional levels found that the irregular histone marks were characteristic to EGFR and CDKN1A, while a large genomic deletion and hyper-DNA methylation were most frequent for CDKN2A.