Y
Yutaka Suzuki
Researcher at University of Tokyo
Publications - 875
Citations - 42146
Yutaka Suzuki is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 85, co-authored 767 publications receiving 35471 citations. Previous affiliations of Yutaka Suzuki include Japan Agency for Medical Research and Development & Institute for the Physics and Mathematics of the Universe.
Papers
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Journal ArticleDOI
Combinatory use of distinct single-cell RNA-seq analytical platforms reveals the heterogeneous transcriptome response
Yukie Kashima,Ayako Suzuki,Ying Liu,Masahito Hosokawa,Hiroko Matsunaga,Masataka Shirai,Kohji Arikawa,Sumio Sugano,Takashi Kohno,Haruko Takeyama,Katsuya Tsuchihara,Yutaka Suzuki +11 more
TL;DR: It is demonstrated that even in the cases where precise information for an individual gene cannot be inferred, the activity of given transcriptional modules can be analyzed and it is shown that it is possible to estimate missing expression information.
Journal ArticleDOI
Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity.
Toshiya Kokaji,Atsushi Hatano,Yuki Ito,Yuki Ito,Katsuyuki Yugi,Miki Eto,Keigo Morita,Satoshi Ohno,Masashi Fujii,Masashi Fujii,Ken-ichi Hironaka,Riku Egami,Akira Terakawa,Takaho Tsuchiya,Haruka Ozaki,Hiroshi Inoue,Shinsuke Uda,Hiroyuki Kubota,Yutaka Suzuki,Kazutaka Ikeda,Makoto Arita,Makoto Arita,Masaki Matsumoto,Keiichi I. Nakayama,Akiyoshi Hirayama,Tomoyoshi Soga,Shinya Kuroda +26 more
TL;DR: Transomics network analysis revealed that regulation of glucose-responsive liver metabolism is mediated through different mechanisms in healthy and obese states, and rapid changes in allosteric regulators and substrates and in gene expression dominate the healthy state, whereas slow changes in geneexpression dominate the obese state.
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Whole Exome Sequencing in Eight Thai Patients With Leber Congenital Amaurosis Reveals Mutations in the CTNNA1 and CYP4V2 Genes.
Worapoj Jinda,Todd D. Taylor,Yutaka Suzuki,Wanna Thongnoppakhun,Chanin Limwongse,Patcharee Lertrit,Adisak Trinavarat,La-ongsri Atchaneeyasakul +7 more
TL;DR: It is demonstrated that causative variants identified in the CTNNA1 and CYP4V2 genes are also associated with LCA, which expands the spectrum of LCA-associated genes, which is a benefit for molecular diagnosis.
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A comparison of the rest complex binding patterns in embryonic stem cells and epiblast stem cells.
TL;DR: A series of transcriptome analyses in the same cell types unexpectedly showed that the putative target gene transcript levels were not dramatically different despite dynamic changes in the Rest complex binding patterns and chromatin statuses, which suggests that Rest is not the sole determinant of repression at its targets.
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Construction and analysis of full-length cDNA library of Cryptosporidium parvum.
Junya Yamagishi,Hiroyuki Wakaguri,Sumio Sugano,Suguru Kawano,Kozo Fujisaki,Chihiro Sugimoto,Junichi Watanabe,Yutaka Suzuki,Isao Kimata,Xuenan Xuan +9 more
TL;DR: There were 148 inconsistencies out of 562 examined genes between the experimentally described cDNA sequence and the predicted sequence from its genome, and 118 sequences that had little homology against annotated genes of C. parvum were identified as prospective candidates for addable genes.