Y
Yutaka Suzuki
Researcher at University of Tokyo
Publications - 875
Citations - 42146
Yutaka Suzuki is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 85, co-authored 767 publications receiving 35471 citations. Previous affiliations of Yutaka Suzuki include Japan Agency for Medical Research and Development & Institute for the Physics and Mathematics of the Universe.
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Journal ArticleDOI
Long terminal repeats power evolution of genes and gene expression programs in mammalian oocytes and zygotes.
Vedran Franke,Sravya Ganesh,Rosa Karlic,Radek Malik,Josef Pasulka,Filip Horvat,Maja Kuzman,Helena Fulka,Marketa Schmidt Cernohorska,Jana Urbanova,Eliska Svobodova,Jun Ma,Yutaka Suzuki,Fugaku Aoki,Richard M. Schultz,Kristian Vlahoviček,Petr Svoboda +16 more
TL;DR: An extraordinary impact of a group of LTRs from the mammalian endogenous retrovirus-related ERVL retrotransposon class on gene expression in the germline and beyond is reported, which offers means for a comprehensive survey of the genome's expression potential.
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Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation.
Takashi Sutani,Toyonori Sakata,Ryuichiro Nakato,Koji Masuda,Mai Ishibashi,Daisuke Yamashita,Yutaka Suzuki,Tatsuya Hirano,Masashige Bando,Katsuhiko Shirahige +9 more
TL;DR: It is shown that condensin, which is essential for assembling condensed chromosomes, helps to preclude the detrimental effects of gene transcription on mitotic condensation and is associated with and reduces unwound DNA segments generated by transcription, providing a direct link between an in vitro activity of condens in and its in vivo function.
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Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia1
Yutaka Suzuki,Hiroyuki Miura,Atsushi Tanemura,Kinji Kobayashi,Gen Kondoh,Shigetoshi Sano,Kentaro Ozawa,Shigeki Inui,Aya Nakata,Tsutomu Takagi,Masaya Tohyama,Kunihiko Yoshikawa,Satoshi Itami +12 more
TL;DR: The gene encoding a transmembrane glycoprotein LIG-1, of which the extracellular region was organized with the leucine-rich repeats and immunoglobulin-like domains, was disrupted in mice by gene targeting as mentioned in this paper.
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The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3′ processing
Ken-ichiro Abe,Ryoma Yamamoto,Vedran Franke,Minjun Cao,Yutaka Suzuki,Masataka G. Suzuki,Kristian Vlahoviček,Kristian Vlahoviček,Petr Svoboda,Richard M. Schultz,Fugaku Aoki +10 more
TL;DR: The authors found that 1-cell embryos are highly promiscuous, such that intergenic regions are extensively expressed and thousands of genes are transcribed at comparably low levels, and that transcription can occur in the absence of defined core-promoter elements.
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Analysis of Small Human Proteins Reveals the Translation of Upstream Open Reading Frames of mRNAs
Masaaki Oyama,Chiharu Itagaki,Hiroko Hata,Yutaka Suzuki,Tomonori Izumi,Tohru Natsume,Toshiaki Isobe,Sumio Sugano +7 more
TL;DR: This investigation provides the first direct evidence of translation of upstream ORFs in human cells, which could greatly change the current outline of the human proteome.