Y
Yutaka Suzuki
Researcher at University of Tokyo
Publications - 875
Citations - 42146
Yutaka Suzuki is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 85, co-authored 767 publications receiving 35471 citations. Previous affiliations of Yutaka Suzuki include Japan Agency for Medical Research and Development & Institute for the Physics and Mathematics of the Universe.
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Journal ArticleDOI
Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes
Sachiyo Mimaki,Yukari Totsuka,Yutaka Suzuki,Chikako Nakai,Masanori Goto,Motohiro Kojima,Hirofumi Arakawa,Hirofumi Arakawa,Shigekazu Takemura,Shogo Tanaka,Shigeru Marubashi,Masahiko Kinoshita,Tomonari Matsuda,Tatsuhiro Shibata,Hitoshi Nakagama,Atsushi Ochiai,Shoji Kubo,Shoji Nakamori,Hiroyasu Esumi,Katsuya Tsuchihara +19 more
TL;DR: In this paper, the authors performed whole-exome analysis on four cases of cholangiocarcinoma among the printing workers and found that an average of 44.8 somatic mutations were detected per Mb in the genome of the workers of a printing company in Osaka, Japan.
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Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene.
Akihiko Ishimura,Minoru Terashima,Hiroshi Kimura,Keiko Akagi,Yutaka Suzuki,Sumio Sugano,Takeshi Suzuki +6 more
TL;DR: It is discovered that over-expression of Jmjd2c increased the expression of Mdm2 oncogene dependent on its demethylase activity, which led to the reduction of p53 tumor suppressor gene product in the cells.
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A GC-rich sequence feature in the 3' UTR directs UPF1-dependent mRNA decay in mammalian cells.
TL;DR: It is found that 3' U TR but not 5' UTRs or open reading frames of UPF1 targets have GC-rich motifs embedded in high GC-content regions, which highlight the important features of UpF1 target 3'UTRs.
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Characterization of genomic organization of the adenosine A2A receptor gene by molecular and bioinformatics analyses
Liqun Yu,Martin C. Frith,Yutaka Suzuki,Robert A. Peterfreund,Tom Gearan,Sumio Sugano,Michael A. Schwarzschild,Zhiping Weng,J. Stephen Fink,J. Stephen Fink,Jiang-Fan Chen,Jiang-Fan Chen +11 more
TL;DR: Combined molecular and bioinformatics analyses revealed a new A(2A)R genomic structure, with conserved coding exons 2 and 3 and divergent, tissue-specific exon 1 variants encoding for 5'-UTR.
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The eta isoform of protein kinase C is localized on rough endoplasmic reticulum.
Kazuhiro Chida,Hiroshi Sagara,Yutaka Suzuki,Akiko Murakami,Shin Ichi Osada,Shigeo Ohno,K Hirosawa,Toshio Kuroki +7 more
TL;DR: It is reported here that this isoform of protein kinase C is localized on the rough endoplasmic reticulum in transiently expressing COS1 cells and constitutively expressing keratinocytes, and demonstrated the absence of a nuclear localization signal in the pseudosubstrate sequence.