Institution
Anthony Nolan
Nonprofit•London, England, United Kingdom•
About: Anthony Nolan is a nonprofit organization based out in London, England, United Kingdom. It is known for research contribution in the topics: Transplantation & Human leukocyte antigen. The organization has 230 authors who have published 272 publications receiving 13641 citations.
Papers published on a yearly basis
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TL;DR: It was decided to form a subcommittee to coordinate the naming of alleles of the genes encoding the killer-cell immunoglobulin-like receptors (KIRs) and a request has been made by the International Union of Immunological Societies to provide a standardized nomenclature for the expressed protein products of the KIR genes.
329 citations
University of Tartu1, Estonian Biocentre2, University of Cambridge3, Arizona State University4, University of California, Berkeley5, Armenian National Academy of Sciences6, Russian Academy of Sciences7, University of Auckland8, Pennsylvania State University9, University of Winchester10, Wellcome Trust Sanger Institute11, University of Copenhagen12, Bashkir State University13, Kazan Federal University14, Georgia Institute of Technology15, University of Pennsylvania16, Centre national de la recherche scientifique17, Eijkman Institute for Molecular Biology18, Massey University19, University of Dhaka20, Aarhus University21, Griffith University22, Josip Juraj Strossmayer University of Osijek23, Academy of Sciences of Uzbekistan24, Kuban State Medical University25, L.N.Gumilyov Eurasian National University26, Nazarbayev University27, North-Eastern Federal University28, Academy of Medical Sciences, United Kingdom29, Anthony Nolan30, University College London31, University of St Andrews32, University of Kharkiv33, International Burch University34, National Academy of Sciences of Belarus35, Radboud University Nijmegen36, King Abdullah University of Science and Technology37, Stanford University38, University of Arizona39, Stony Brook University40, University Hospital of North Norway41, Estonian Academy of Sciences42
TL;DR: A study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples, infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky, and hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
Abstract: It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
325 citations
TL;DR: A mechanism that modulates frequencies of the NK subsets displaying diverse levels of missing-self response is inferred, a system that reduces the presence of KIR-expressing subsets that display either too strong or too weak a response and effectively replaces them with NKG2A- expressing cells in the repertoire.
301 citations
John Radcliffe Hospital1, Anthony Nolan2, Royal Free Hospital3, Ludwig Maximilian University of Munich4, Cancer Research UK5, Biomedical Primate Research Centre6, Memorial Sloan Kettering Cancer Center7, Hoffmann-La Roche8, University of Geneva9, University of Vienna10, Stanford University11, Leiden University12, Harvard University13, University of Copenhagen14, University of California, Los Angeles15
TL;DR: Recently a number of new genes have been identified within the HLA region including some whose functions are related to HLA class I and I1 genes and the Committee discussed what its strategy should be for the naming of these and further new genes.
297 citations
TL;DR: In this paper, suicidal CD44v6-targeted T cells were found to have potent antitumor effects against primary AML and multiple myeloma (MM) cells in immunocompromised mice.
290 citations
Authors
Showing all 236 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Ghulam J. Mufti | 88 | 687 | 30934 |
| Nigel H. Russell | 76 | 502 | 21810 |
| Steven G.E. Marsh | 65 | 487 | 20763 |
| Frits van Rhee | 61 | 323 | 14983 |
| Charles Craddock | 60 | 302 | 13660 |
| James Robinson | 48 | 172 | 11429 |
| John Barrett | 44 | 114 | 7428 |
| Bronwen E. Shaw | 42 | 286 | 6191 |
| Richard Szydlo | 41 | 166 | 4775 |
| Nancy F. Hensel | 34 | 87 | 4754 |
| Alejandro Madrigal | 29 | 101 | 3529 |
| Lawrence S. Lamb | 28 | 88 | 2311 |
| Susana Gómez | 27 | 69 | 1891 |
| Ann-Margaret Little | 26 | 63 | 2443 |
| J. Alejandro Madrigal | 26 | 105 | 2577 |