Institution
Baylor College of Medicine
Education•Houston, Texas, United States•
About: Baylor College of Medicine is a education organization based out in Houston, Texas, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 49134 authors who have published 94814 publications receiving 5064921 citations.
Topics: Population, Cancer, Gene, Medicine, Transplantation
Papers published on a yearly basis
Papers
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University of California, San Diego1, Virginia Mason Medical Center2, Johns Hopkins University3, Saint Louis University4, Washington University in St. Louis5, Boston Children's Hospital6, Baylor College of Medicine7, MetroHealth8, Cleveland Clinic9, Children's National Medical Center10, Duke University11, Indiana University12, Riley Hospital for Children13, University of California, San Francisco14, Virginia Commonwealth University15, National Institutes of Health16
TL;DR: Treatment of NAFLD should incorporate strategies to improve QOL, especially physical health, and Cirrhosis was associated with poorer physical health after adjusting for potential confounders.
122 citations
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University of California, San Francisco1, Baylor College of Medicine2, University of Southern California3, Medical University of Warsaw4, Katholieke Universiteit Leuven5, University of Pittsburgh6, Children's Hospital of Wisconsin7, Complutense University of Madrid8, University of Michigan9, Boston Children's Hospital10, Hospital Italiano de Buenos Aires11, Cincinnati Children's Hospital Medical Center12, University of Bonn13, Hospital for Sick Children14, University of Birmingham15, Jackson Memorial Hospital16, Children's Hospital Los Angeles17, University of Miami18, Mount Sinai Hospital19, University of Toronto20, Cardinal Glennon Children's Hospital21, Brigham and Women's Hospital22, Leiden University Medical Center23
TL;DR: Post-natal data from the IFCIR is presented to suggest potential benefit to fetal therapy among pregnancies considered for possible intervention and support proposals for additional work.
122 citations
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TL;DR: A method is presented that efficiently generates realistic all‐atom protein structures starting from the Cα atom positions, as obtained from extensive coarse‐grain simulations, and shows good correspondence and little distortion in the protein folding landscape.
Abstract: Multiscale methods are becoming increasingly promising as a way to characterize the dynamics of large protein systems on biologically relevant time-scales. The underlying assumption in multiscale simulations is that it is possible to move reliably between different resolutions. We present a method that efficiently generates realistic all-atom protein structures starting from the C(alpha) atom positions, as obtained for instance from extensive coarse-grain simulations. The method, a reconstruction algorithm for coarse-grain structures (RACOGS), is validated by reconstructing ensembles of coarse-grain structures obtained during folding simulations of the proteins src-SH3 and S6. The results show that RACOGS consistently produces low energy, all-atom structures. A comparison of the free energy landscapes calculated using the coarse-grain structures versus the all-atom structures shows good correspondence and little distortion in the protein folding landscape.
122 citations
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TL;DR: The data show that the hyperacetylation of Tau by p300 histone acetyltransferase (HAT) disfavors LLPS, inhibits heparin-induced aggregation, and impedes access to LLPS-initiated microtubule assembly.
Abstract: Neuropathological aggregates of the intrinsically disordered microtubule-associated protein Tau are hallmarks of Alzheimer’s disease, with decades of research devoted to studying the protein’s aggregation properties both in vitro and in vivo. Recent demonstrations that Tau is capable of undergoing liquid-liquid phase separation (LLPS) reveal the possibility that protein-enriched phase separated compartments could serve as initiation sites for Tau aggregation, as shown for other amyloidogenic proteins, such as the Fused in Sarcoma protein (FUS) and TAR DNA-binding protein-43 (TDP-43). Although truncation, mutation, and hyperphosphorylation have been shown to enhance Tau LLPS and aggregation, the effect of hyperacetylation on Tau aggregation remains unclear. Here, we investigate how the acetylation of Tau affects its potential to undergo phase separation and aggregation. Our data show that the hyperacetylation of Tau by p300 histone acetyltransferase (HAT) disfavors LLPS, inhibits heparin-induced aggregation, and impedes access to LLPS-initiated microtubule assembly. We propose that Tau acetylation prevents the toxic effects of LLPS-dependent aggregation but, nevertheless, contributes to Tau loss-of-function pathology by inhibiting Tau LLPS-mediated microtubule assembly.
122 citations
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TL;DR: It is shown that genetic deletion of all Cplxs expressed in the mouse brain causes a reduction in Ca2+-triggered and spontaneous neurotransmitter release at both excitatory and inhibitory synapses.
Abstract: Complexins (Cplxs) are key regulators of synaptic exocytosis, but whether they act as facilitators or inhibitors is currently being disputed controversially. We show that genetic deletion of all Cplxs expressed in the mouse brain causes a reduction in Ca2+-triggered and spontaneous neurotransmitter release at both excitatory and inhibitory synapses. Our results demonstrate that at mammalian central nervous system synapses, Cplxs facilitate neurotransmitter release and do not simply act as inhibitory clamps of the synaptic vesicle fusion machinery.
122 citations
Authors
Showing all 49661 results
Name | H-index | Papers | Citations |
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Eric S. Lander | 301 | 826 | 525976 |
Shizuo Akira | 261 | 1308 | 320561 |
Eric N. Olson | 206 | 814 | 144586 |
Hagop M. Kantarjian | 204 | 3708 | 210208 |
Ronald M. Evans | 199 | 708 | 166722 |
Francis S. Collins | 196 | 743 | 250787 |
Scott M. Grundy | 187 | 841 | 231821 |
Patrick O. Brown | 183 | 755 | 200985 |
Eric Boerwinkle | 183 | 1321 | 170971 |
Paul G. Richardson | 183 | 1533 | 155912 |
Yusuke Nakamura | 179 | 2076 | 160313 |
Chris Sander | 178 | 713 | 233287 |
Richard A. Young | 173 | 520 | 126642 |
Feng Zhang | 172 | 1278 | 181865 |
Richard A. Gibbs | 172 | 889 | 249708 |