Boston University

About: Boston University is a education organization based out in Boston, Massachusetts, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 48688 authors who have published 119622 publications receiving 6276020 citations. The organization is also known as: BU & Boston U.

Lower Class Culture As a Generating Milieu of Gang Delinquency

Abstract: The etiology of delinquency has long been a controversial issue, and is particularly so at present. The bulk of the substantive data on which the following material is based was collected in connection with a service-research project in the control of gang delinquency. The major sets of etiological factors adduced to explain delinquency are, in simplified terms, the physiological, the psychodynamic, and the environmental. In the case of "gang" delinquency, the cultural system which exerts the most direct influence on behavior is that of the lower class community itself—a long-established, distinctively patterned tradition with integrity of its own—rather than a so-called "delinquent subculture". The dominant concern over "trouble" involves a distinction of critical importance for the lower class community—that between "law-abiding" and "non-law-abiding" behavior. The one-sex peer group is a highly prevalent and significant structural form in the lower class community.

Genome-wide association study of blood pressure and hypertension

Abstract: Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10(-7). The top ten loci for SBP and DBP were incorporated into a risk score; mean BP and prevalence of hypertension increased in relation to the number of risk alleles carried. When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 × 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1). Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension.