Showing papers by "British Geological Survey published in 2009"

Phase III Randomized Comparison of Gemcitabine Versus Gemcitabine Plus Capecitabine in Patients With Advanced Pancreatic Cancer

Abstract: Purpose Both gemcitabine (GEM) and fluoropyrimidines are valuable treatment for advanced pancreatic cancer. This open-label study was designed to compare the overall survival (OS) of patients randomly assigned to GEM alone or GEM plus capecitabine (GEM-CAP). Patients and Methods Patients with previously untreated histologically or cytologically proven locally advanced or metastatic carcinoma of the pancreas with a performance status ≤ 2 were recruited. Patients were randomly assigned to GEM or GEM-CAP. The primary outcome measure was survival. Meta-analysis of published studies was also conducted. Results Between May 2002 and January 2005, 533 patients were randomly assigned to GEM (n = 266) and GEM-CAP (n = 267) arms. GEM-CAP significantly improved objective response rate (19.1% v 12.4%; P = .034) and progression-free survival (hazard ratio [HR], 0.78; 95% CI, 0.66 to 0.93; P = .004) and was associated with a trend toward improved OS (HR, 0.86; 95% CI, 0.72 to 1.02; P = .08) compared with GEM alone. This trend for OS benefit for GEM-CAP was consistent across different prognostic subgroups according to baseline stratification factors (stage and performance status) and remained after adjusting for these stratification factors (P = .077). Moreover, the meta-analysis of two additional studies involving 935 patients showed a significant survival benefit in favor of GEM-CAP (HR, 0.86; 95% CI, 0.75 to 0.98; P = .02) with no intertrial heterogeneity. Conclusion On the basis of our trial and the meta-analysis, GEM-CAP should be considered as one of the standard first-line options in locally advanced and metastatic pancreatic cancer.

Integrated analysis of risks of coastal flooding and cliff erosion under scenarios of long term change

Abstract: The risks to human populations in coastal areas are changing due to climate and socio-economic changes, and these trends are predicted to accelerate during the twenty-first century. To understand these changing risks, and the resulting choices and pathways to successful management and adaptation, broad-scale integrated assessment is essential. Due to their complexity the two risks of flooding and erosion are usually managed independently, yet frequently they are interconnected by longshore exchange of sediments and the resulting broad scale morphological system behaviour. In order to generate new insights into the effects of climate change and coastal management practises on coastal erosion and flood risk, we present an integrated assessment of 72 km of shoreline over the twenty-first century on the East Anglian coast of England which is a site of significant controversy about how to manage coastal flood and erosion risks over the twenty-first century. A coupled system of hydrodynamic, morphological, reliability and socio-economic models has been developed for the analysis, implemented under scenarios of coastal management, climate and socio-economic change. The study is unique in coastal management terms because of the large spatial scale and extended temporal scale over which the analysis is quantified. This study for the first time quantifies what has for some years been argued qualitatively: the role of sediments released from cliff erosion in protecting neighbouring low-lying land from flooding. The losses and benefits are expressed using the common currency of economic risk. The analysis demonstrates that over the twenty-first century, flood risk in the study area is expected to be an order of magnitude greater than erosion risk. Climate and socio-economic change and coastal management policy have a significant influence on flood risk. This study demonstrates that the choices concerning coastal management are profound, and there are clear tradeoffs between erosion and flood impacts.

Hf-Nd input flux in the Izu-Mariana subduction zone and recycling of subducted material in the mantle

Abstract: In subduction zones, two major mass fluxes compete: the input flux of altered oceanic crust and sediments subducted into the mantle and the output flux of magma that forms the volcanic arc. While the composition and the amount of material erupted along volcanic arcs are relatively well known, the chemical and isotopic composition of the subducted material (altered oceanic crust and sediments) is poorly constrained and is an important factor in the mass balance calculation. Ocean Drilling Program Leg 185 in the Western Pacific used systematic sampling of the altered basaltic basement and sediment pile and the creation of composite mixtures to quantify the total chemical flux subducted at the Izu-Mariana margin. Here, we report Hf and Nd isotopic compositions of materials recovered from this Leg. The Hf and Nd isotopic compositions of altered basalts from Hole 801C are indistinguishable from those of recent unaltered Pacific mid-ocean ridge basalt, suggesting that hydrothermal alteration had no effect on either isotopic systems. The complete Site 1149 sedimentary pile has a weighted average ɛNd of −5.9 and ɛHf of +4.4, values similar to those of Fe-Mn crusts and nodules. Therefore, the Hf and Nd isotopic compositions of the sediments collected at Site 1149 indicate minimal contributions from continental detrital material to the rare earth elements and high field strength elements. However, the Hf isotopic budget of the oldest sediments is more influenced by continental material than the younger sediments, despite the large distances to continental masses 130 Ma ago. In the Izu subduction zone, we calculate a sedimentary input of less than about 2% in the volcanic lava source. In contrast, at least 85% of the sedimentary Nd and Hf are recycled into the mantle to affect its general composition. Assuming that sediments have been recycled in a similar manner into the mantle for millions of years, large chemical heterogeneities must be produced in the mantle. In addition, the depletion of the mantle due to the extraction of continental crust must be partly counterbalanced by the injection of vast quantities of enriched sedimentary material.

The Eo-Cimmerian (Late? Triassic) orogeny in North Iran

Abstract: The Eo-Cimmerian orogen results from the Late Triassic collision of Iran, a microplate of Gondwanan affinity, with the southern margin of Eurasia. The orogen is discontinuously exposed along the northern side of the Alborz Mountains of North Iran below the siliciclastic deposits of the Shemshak Group (Late Triassic–Jurassic). A preserved section of the external part of the belt crops out in the Neka Valley (eastern Alborz) south of Gorgan. Here the Mesozoic successions (Shemshak Group–Upper Cretaceous limestones) overlay a pre-Jurassic Eo-Cimmerian thrust stack with a sharp unconformity. The stack includes the Gorgan Schists, an Upper Ordovician–Lower Silurian low-grade metamorphic complex, overthrusted southward above a strongly deformed Late Palaeozoic–Middle Triassic succession belonging to north Iran. In the Talesh Mountains (western Alborz), the Shanderman Complex, previously interpreted as an ophiolitic remnant isolated along the Eo-Cimmerian suture, is considered an allochthonous nappe of deeply subducted continental crust. The new evidence for this is the occurrence of previously unknown eclogites dating to the Carboniferous, and probably related to the Variscan history of Transcaucasia. South of the Shanderman Complex, Upper Palaeozoic slates and carbonates occurring below the Lower Jurassic Shemshak Group also record the occurrence of an Eo-Cimmerian metamorphic event. Based on our new data, the Eo-Cimmerian structures exposed in the Alborz appear to be remnants of a collisional orogen consisting mainly of deformed continental crust where no ophiolites are preserved.

Tracer-derived freshwater composition of the Siberian continental shelf and slope following the extreme Arctic summer of 2007

Abstract: We investigate the freshwater composition of the shelf and slope of the Arctic Ocean north of the New Siberian Islands using geochemical tracer data (? 18O, Ba, and PO*4) collected following the extreme summer of 2007. We find that the anomalous wind patterns that partly explained the sea ice minimum at this time also led to significant quantities of Pacific?derived surface water in the westernmost part of the Makarov Basin. We also find larger quantities of meteoric water near Lomonosov Ridge than were found in 1995. Dissolved barium is depleted in the upper layers in one region of our study area, probably as a result of biological activity in open waters. Increasingly ice?free conditions compromise the quantitative use of barium as a tracer of river water in the Arctic Ocean.

Geochronology of granulitized eclogite from the Ama Drime Massif: Implications for the tectonic evolution of the South Tibetan Himalaya

Abstract: [1] The Ama Drime Massif (ADM) is an elongate north-south trending antiformal feature that extends ∼70 km north across the crest of the South Tibetan Himalaya and offsets the position of the South Tibetan Detachment system. A detailed U(-Th)-Pb geochronologic study of granulitized mafic eclogites and associated rocks from the footwall of the ADM yields important insights into the middle to late Miocene tectonic evolution of the Himalayan orogen. The mafic igneous precursor to the granulitized eclogites is 986.6 ± 1.8 Ma and was intruded into the paleoproterozoic (1799 ± 9 Ma) Ama Drime orthogneiss, the latter being similar in age to rocks previously assigned to the Lesser Himalayan Series in the Himalayan foreland. The original eclogite-facies mineral assemblage in the mafic rocks has been strongly overprinted by granulite facies metamorphism at 750°C and 0.7–0.8 GPa. In the host Ama Drime orthogneiss, the granulite event is correlated with synkinematic sillimanite-grade metamorphism and muscovite dehydration melting. Monazite and xenotime ages indicate that the granulite metamorphism and associated anatexis occurred at <13.2 ± 1.4 Ma. High-grade metamorphism was followed by postkinematic leucogranite dyke emplacement at 11.6 ± 0.4 Ma. This integrated data set indicates that high-temperature metamorphism, decompression, and exhumation of the ADM postdates mid-Miocene south directed midcrustal extrusion and is kinematically linked to orogen-parallel extension.

Automated monitoring of coastal aquifers with electrical resistivity tomography

Abstract: An Automated time-Lapse Electrical Resistivity Tomography (ALERT) system has been developed for the long-term monitoring of coastal aquifers. This ALERT system has been permanently installed in the River Andarax, Almeria, Spain to monitor and manage the impact of climatic change and land-use practice on the underlying Quaternary aquifer. An electrode array, nearly 1.6 km long, has been buried below the normally dry riverbed with electrode take-outs at regular intervals of 10 m. The maximum depth of investigation is about 160 m below ground level. An unmanned, permanent control station, in a secure location, allows the aquifer to be interrogated remotely from the BGS office in the UK. Volumetric geoelectric images of the subsurface can be obtained ‘on demand’ or at regular intervals; thereby eliminating the need for expensive repeat surveys. The entire process from data capture to image on the office PC is fully automated and seamless. The ALERT technology can provide early warning of potential threats to vulnerable water systems such as over-exploitation, rising sea levels, anthropogenic pollutants and seawater intrusion. The electrical images obtained (in space and time) are interpreted in terms of the hydrogeologic features including the seawater-freshwater interface. The timely detection and imaging of groundwater changes can help to regulate pumping and irrigation schemes.

Characterization of seawater intrusion using 2D electrical imaging

Abstract: We have investigated the potential of 2D electrical imaging for the characterization of seawater intrusion using field data from a site in Almeria, SE Spain. Numerical simulations have been run for several scenarios, with a hydrogeological model reflecting the local site conditions. The simulations showed that only the lower salt concentrations of the seawater-freshwater transition zone could be recovered, due to the loss of resolution with depth. We quantified this capability in terms of the cumulative sensitivity associated with the measurement setup and showed that the mismatch between the targeted and imaged parameter values occurs from a certain sensitivity threshold. Similarly, heterogeneity may only be determined accurately if located in an adequately sensitive area. At the field site, we identified seawater intrusion at the scale of a few kilometres down to a hundred metres. Borehole logs show a remarkable correlation with the image obtained from surface data but indicate that the electrically derived mass fraction of pure seawater could not be recovered due to the discrepancy between the in-situ and laboratory-derived petrophysical relationships. Surface-to-hole inversion results suggest that the laterally varying resolution pattern associated with such a setup dominates the image characteristics compared to the laterally more homogeneous resolution pattern of surface only inversion results and hence, surface-to-hole images are not easily interpretable in terms of larger-scale features. Our results indicate that electrical imaging can be used to constrain seawater intrusion models if image appraisal tools are appropriately used to quantify the spatial variation of sensitivity and resolution. The most crucial limitation is probably the apparent non-stationarity of the petrophysical relationship during the imaging process.

What impact will climate change have on rural groundwater supplies in Africa

Abstract: One of the key uncertainties surrounding the impacts of climate change in Africa is the effect on the sustainability of rural water supplies. Many of these water supplies abstract from shallow groundwater (<50 m) and are the sole source of safe drinking water for rural populations. Analysis of existing rainfall and recharge studies suggests that climate change is unlikely to lead to widespread catastrophic failure of improved rural groundwater supplies. These require only 10 mm of recharge annually per year to support a hand pump, which should still be achievable for much of the continent, although up to 90 million people may be affected in marginal groundwater recharge areas (200–500 mm annual rainfall). Lessons learnt from groundwater source behaviour during recent droughts, substantiated by groundwater modelling, indicate that increased demand on dispersed water points, as shallow unimproved sources progressively fail, poses a much greater risk of individual source failure than regional resource depletion. Low yielding sources in poor aquifers are most at risk. Predicted increased rainfall intensity may also increase the risk of contamination of very shallow groundwater. Looking to the future, an increase in major groundwater-based irrigation systems, as food prices rise and surface water becomes more unreliable, may threaten long-term sustainability as competition for groundwater increases. To help prepare for increased climate variability, it is essential to understand the balance between water availability, access to water, and use/demand. In practice, this means increasing access to secure domestic water, understanding and mapping renewable and non-renewable groundwater resources, promoting small-scale irrigation and widening the scope of early warning systems and mapping to include access to water.

Trans-Atlantic Slavery: Isotopic Evidence for Forced Migration to Barbados

Abstract: The question of the ultimate origin of African slaves is one of the most perplexing in the history of trans-Atlantic slavery. Here we present the results of a small, preliminary isotopic study that was conducted in order to determine the geographical origin of 25 enslaved Africans who were buried at the Newton plantation, Barbados, sometime between the late 17th and early 19th century. In order to gain a more nuanced understanding of the slaves' origin, we used a combination of carbon, nitrogen, oxygen, and strontium isotope analyses. Carbon and nitrogen isotope ratios were determined in bone and dentinal collagen; oxygen and strontium isotopes were measured in tooth enamel. Results suggest that the majority of individuals were born on the island, if not the estate itself. Seven individuals, however, yielded enamel oxygen and strontium ratios that are inconsistent with a Barbadian origin, which strongly suggests that we are dealing with first-generation captives who were brought to the island with the slave trade. This idea is also supported by the fact that their carbon and nitrogen stable isotope values differ markedly between their teeth and bones. These intra-skeletal shifts reflect major dietary changes that probably coincided with their enslavement and forced migration to Barbados. While it is impossible to determine their exact origins, the results clearly demonstrate that the slaves did not all grow up in the same part of Africa. Instead, the data seem to suggest that they originated from at least three different areas, possibly including the Gold Coast and the Senegambia.

A composite C-isotope profile for the Neoproterozoic Dalradian Supergroup of Scotland and Ireland

Abstract: The Neoproterozoic Dalradian Supergroup is a dominantly siliciclastic metasedimentary succession in the Caledonian orogenic belt of Scotland and Ireland. Despite polyphase deformation and greenschist- to upper amphibolite-facies metamorphism, carbonate units distributed throughout the Dalradian record marked δ 13 C carbonate excursions that can be linked to those associated with key environmental events of Neoproterozoic time. These include: (1) tentative correlation of the Ballachulish Limestone with the c . 800 Ma Bitter Springs anomaly; (2) the presence of the pre-Marinoan Trezona anomaly and 635 Ma Marinoan-equivalent cap carbonate sequence in rocks of the middle Easdale Subgroup; (3) the terminal Proterozoic ( c . 600–551 Ma) Wonoka–Shuram anomaly in the Girlsta Limestone on Shetland. These linkages strengthen previously inferred correlations of the Stralinchy–Reelan formations and the Inishowen–Loch na Cille–MacDuff ice-rafted debris beds to the respectively 635 Ma Marinoan and 582 Ma Gaskiers glaciations, and suggest that the oldest Dalradian glacial unit, the Port Askaig Formation, represents one of the c . 750–690 Ma Sturtian glacial episodes. These δ 13 C data and resulting correlations provide more robust constraints on the geological evolution of the Dalradian Supergroup than anything hitherto available and enhance its utility in helping refine understanding of Neoproterozoic Earth history.

A new approach to single shot laser ablation analysis and its application to in situ Pb/U geochronology

Abstract: A novel approach to laser ablation Pb/U geochronology is presented that allows accurate determination of isotope ratios from a single pulse of a 193 nm laser. Data are acquired using a low volume ablation cell that facilitates: (1) production of a high density particle stream; and (2) a short (∼0.5 s) sample washout time. Isotope ratios from an individual laser pulse are calculated by integrating the baseline-subtracted total number of counts for the entire pulse and assigning an internal uncertainty based on counting statistics. This ‘total signal integration’ method eliminates the effects of differing detector response times, particularly in multi-collector-inductively coupled plasma-mass spectrometry (MC-ICP-MS), providing an alternative means to quantify transient signals. Data from reference zircons indicate that it is possible to consistently measure 206Pb/238U and 207Pb/206Pb ratios with external reproducibilities of 2% and 2.8% (2SD) respectively, using a similar amount of material to standard static ablation protocols. Decreasing sample consumption to ∼14 ng zircon (∼75% less than the ‘normal’ ablated mass) results in only a modest increase in the uncertainty to ∼5% on the 206Pb/238U ratio. By analysing consecutive laser pulses from the same ablation site, isotopic depth profiles can be generated with a depth resolution of ∼0.1 µm pulse−1. This technique offers a new opportunity to identify complexities within accessory minerals that were previously beyond the spatial resolution of laser based geochronology methods.

Virtual seismometers in the subsurface of the Earth from seismic interferometry

Abstract: Earthquakes often occur in areas that lack an array of seismometers, resulting in a scarcity of local measurements from some regions of great geological interest. In such regions, some earthquakes themselves may be turned into virtual seismometers that are capable of measuring strain caused by passing waves from other earthquakes.

Microlite transfer by disaggregation of mafic inclusions following magma mixing at Soufrière Hills volcano, Montserrat

Abstract: The Soufriere Hills volcano on Montserrat has for the past 12 years been erupting andesite with basaltic to basaltic–andesite inclusions. The andesite contains a wide variety of phenocryst textures and strongly zoned microlites. Analysis of minor elements in both phenocrysts and microlites allows us to put detailed constraints on their origins. Compositions of clinopyroxene, from overgrowth rims on quartz and orthopyroxene and coarse-grained breakdown rims on hornblende, are identical to those from the mafic inclusions, indicating that these rims form during interaction with mafic magma. In contrast, resorbed quartz and reversely zoned orthopyroxenes form during heating. Microlites of plagioclase and orthopyroxene are chemically distinct from the phenocrysts, being enriched in Fe and Mg, and Al and Ca respectively. However, microlites of plagioclase, orthopyroxene and clinopyroxene are indistinguishable from the compositions of these phases in the mafic inclusions. We infer that the inclusions disaggregated under conditions of high shear stress during ascent in the conduit, transferring mafic material into the andesite groundmass. The mafic component of the system is therefore greater than previously thought. The presence of mafic-derived microlites in the andesite groundmass also means that care must be taken when using this as a starting material for phase equilibrium experiments.

Isotope domain mapping of 87Sr/86Sr biosphere variation on the Isle of Skye, Scotland

Abstract: The potential of 87 Sr/ 86 Sr isotope composition for tracking and determining the origin of material, whether it is humans, animals, water or wine can be fully realized only if high-quality reference datasets are available against which to compare the unknowns. This is currently not the case. Despite the rapid increase in 87 Sr/ 86 Sr-based provenance studies of biosphere materials there are no well-documented maps available. Most researchers resort to generating reference maps from a variety of geological datasets plus the analysis of sparse ’environmental9 samples. A major reason for this lack of reference material is the investment needed to undertake systematic sampling and analysis over large areas. A further problem is associated with the choice of proxy material, as organisms differ in their habitat and exploitation of resources. In this paper various approaches to isotope biosphere sampling are considered, some of the problems are assessed, the precision required for the study of human populations is discussed, and a first attempt is made to condense all of the available information into an ’isotope package9 map. The work is based on a study undertaken on the Isle of Skye, in the Inner Hebrides, and reduces the complexity of geological and isotope data into five main 87 Sr/ 86 Sr packages: Package 1 (northern area) = 0.705–0.7092; Package 2 (NE coast) = 0.7082–0.7102; Package 3 (granitic rocks) = 0.716–0.720; Package 4 (metamorphic rocks) = 0.7092–0.7188; Package 5 (seawater) = 0.7092 ± 0.005% (2σ). The approach of trying to constrain the isotope composition of certain areas and/or lithologies offers the possibility of extrapolating to other similar areas without having to sample at the original density.

Initial geological considerations before installing ground source heat pump systems

Abstract: The performance of an open- or closed-loop ground source heat pump system depends on local geological conditions. It is important that these are determined as accurately as possible when designing a system, to maximize efficiency and minimize installation costs. Factors that need to be considered are surface temperature, subsurface temperatures down to 100–200 m, thermal conductivities and diffusivities of the soil and rock layers, groundwater levels and flows, and aquifer properties. In addition, rock strength is a critical factor in determining the excavation or drilling method required at a site and the associated costs. The key to determining all of these factors is an accurate conceptual site-scale model of the ground conditions (soils, geology, thermogeology, engineering geology and hydrogeology). The British Geological Survey has used the modern digital geological mapping of the UK as a base onto which appropriate attributes can be assigned. As a result it is possible to generate regional maps of surface and subsurface temperatures, rock strength and depth to water. This information can be used by designers, planners and installers of ground source heat pump systems. The use of appropriate geological factors will assist in creating a system that meets the heating or cooling load of the building without unnecessary overengineering.