Institution
Cardiff University
Education•Cardiff, United Kingdom•
About: Cardiff University is a education organization based out in Cardiff, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 34188 authors who have published 82643 publications receiving 3046531 citations. The organization is also known as: University of Cardiff & University College of South Wales and Monmouthshire.
Topics: Population, Context (language use), Catalysis, Galaxy, Poison control
Papers published on a yearly basis
Papers
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TL;DR: The structure, biological function and the regulation of the C/EBP family are reviewed, which have revealed an immense complexity with the potential existence of cell/tissue- and species-specific differences.
Abstract: CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that all contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in dimerization and DNA binding. At least six members of the family have been isolated and characterized to date (C/EBPa–C/EBPz), with further diversity produced by the generation of different sized polypeptides, predominantly by differential use of translation initiation sites, and extensive protein–protein interactions both within the family and with other transcription factors. The function of the C/EBPs has recently been investigated by a number of approaches, including studies on mice that lack specific members, and has identified pivotal roles of the family in the control of cellular proliferation and differentiation, metabolism, inflammation and numerous other responses, particularly in hepatocytes, adipocytes and haematopoietic cells. The expression of the C/EBPs is regulated at multiple levels during several physiological and pathophysiological conditions through the action of a range of factors, including hormones, mitogens, cytokines, nutrients and certain toxins. The mechanisms through which the C/EBP members are regulated during such conditions have also been the focus of several recent studies and have revealed an immense complexity with the potential existence of cell/tissue- and species-specific differences. This review deals with the structure, biological function and the regulation of the C/EBP family.
1,330 citations
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TL;DR: A summary of the 2010 version of the EAU guidelines on the treatment of advanced, relapsing, and castration-resistant prostate cancer (CRPC) summarise the most recent findings and put them into clinical practice.
1,327 citations
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28 Apr 1994TL;DR: A laparoscopic surgical instrument which may be in the form of forceps or a cutter has, at the end of a hollow tube for introduction through the body cavity wall, a housing, a pair of pivotally mounted metallic jaws, a reciprocable control rod in the tube, and an actuator secured to the control rod as mentioned in this paper.
Abstract: A laparoscopic surgical instrument which may be in the form of forceps or a cutter has, at the end of a hollow tube for introduction through the body cavity wall, a housing, a pair of pivotally mounted metallic jaws, a reciprocable control rod in the tube, and an actuator secured to the control rod. The actuator has a pair of guide grooves which are oppositely inclined with respect to a longitudinal axis of the instrument, and each jaw has a lug which fits in a respective groove, the lugs being spaced from the jaw pivots so that reciprocation of the control rod causes opening and closing of the jaws. The housing and the actuator are electrically insulating and the jaw pivots are spaced apart to achieve electrical isolation of one jaw from the other, for applying a radio frequency voltage across the jaws for bipolar electrosurgery.
1,321 citations
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TL;DR: An analysis of all 11,974 bipolar disorder cases and 51,792 controls confirmed genome-wide significant evidence of association for CACNA1C and identified a new intronic variant in ODZ4, and a pathway comprised of subunits of calcium channels enriched in bipolar disorder association intervals was identified.
Abstract: We conducted a combined genome-wide association study (GWAS) of 7,481 individuals with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS Consortium. Our replication study tested 34 SNPs in 4,496 independent cases with bipolar disorder and 42,422 independent controls and found that 18 of 34 SNPs had P < 0.05, with 31 of 34 SNPs having signals with the same direction of effect (P = 3.8 × 10−7). An analysis of all 11,974 bipolar disorder cases and 51,792 controls confirmed genome-wide significant evidence of association for CACNA1C and identified a new intronic variant in ODZ4. We identified a pathway comprised of subunits of calcium channels enriched in bipolar disorder association intervals. Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. Our replication results imply that increasing sample sizes in bipolar disorder will confirm many additional loci.
1,312 citations
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TL;DR: Current evidence is insufficient to warrant widespread population-based screening by prostate-specific antigen (PSA) for PCa, and these EAU guidelines on PCa summarise the most recent findings and put them into clinical practice.
1,310 citations
Authors
Showing all 34629 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rob Knight | 201 | 1061 | 253207 |
Stephen V. Faraone | 188 | 1427 | 140298 |
John J.V. McMurray | 178 | 1389 | 184502 |
David R. Williams | 178 | 2034 | 138789 |
John Hardy | 177 | 1178 | 171694 |
Dorret I. Boomsma | 176 | 1507 | 136353 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Anders Björklund | 165 | 769 | 84268 |
Edward T. Bullmore | 165 | 746 | 112463 |
Peter A. R. Ade | 162 | 1387 | 138051 |
Michael John Owen | 160 | 1110 | 135795 |
Gavin Davies | 159 | 2036 | 149835 |
Suvadeep Bose | 154 | 960 | 129071 |
Todd Adams | 154 | 1866 | 143110 |
John R. Hodges | 149 | 812 | 82709 |