Cardiff University

About: Cardiff University is a education organization based out in Cardiff, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 34188 authors who have published 82643 publications receiving 3046531 citations. The organization is also known as: University of Cardiff & University College of South Wales and Monmouthshire.

Evaluating the effects of SARS-CoV-2 Spike mutation D614G on transmissibility and pathogenicity

Abstract: In February 2020 a substitution at the interface between SARS-CoV-2 Spike protein subunits, Spike D614G, was observed in public databases. The Spike 614G variant subsequently increased in frequency in many locations throughout the world. Global patterns of dispersal of Spike 614G are suggestive of a selective advantage of this variant, however the origin of Spike 614G is associated with early colonization events in Europe and subsequent radiations to the rest of the world. Increasing frequency of 614G may therefore be due to a random founder effect. We investigate the hypothesis for positive selection of Spike 614G at the level of an individual country, the United Kingdom, using more than 25,000 whole genome SARS-CoV-2 sequences collected by COVID-19 Genomics UK Consortium. Using phylogenetic analysis, we identify Spike 614G and 614D clades with unique origins in the UK and from these we extrapolate and compare growth rates of co-circulating transmission clusters. We find that Spike 614G clusters are introduced in the UK later on average than 614D clusters and grow to larger size after adjusting for time of introduction. Phylodynamic analysis does not show a significant increase in growth rates for clusters with the 614G variant, but population genetic modelling indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We also investigate the potential influence of Spike 614D versus G on virulence by matching a subset of records to clinical data on patient outcomes. We do not find any indication that patients infected with the Spike 614G variant have higher COVID-19 mortality, but younger patients have slightly increased odds of 614G carriage. Despite the availability of a very large data set, well represented by both Spike 614 variants, not all approaches showed a conclusive signal of higher transmission rate for 614G, but significant differences in growth, size, and composition of these lineages indicate a need for continued study.

Determinants of export performance in a European context

Abstract: Drawing attention to certain important gaps in the exporting literature, develops and evaluates a model of export performance using a sample of regular exporters from a small European Union country, in their trading activities with overseas distributors. Integrates and views specific firm characteristics, export commitment and export‐related perception variables as potentially important factors in explaining firm performance in the export market context. Tests the model in a three‐step procedure employing multiple regression analysis and identifies several elements that are related directly to export performance. Discusses the implications of the study for both business practitioners and public policy makers and highlights future research directions.

Support for the involvement of large copy number variants in the pathogenesis of schizophrenia

Abstract: We investigated the involvement of rare ( 1 Mb were 2.26 times more common in cases (P = 0.00027), with the effect coming mostly from deletions (odds ratio, OR = 4.53, P = 0.00013) although duplications were also more common (OR = 1.71, P = 0.04). Two large deletions were found in two cases each, but in no controls: a deletion at 22q11.2 known to be a susceptibility factor for schizophrenia and a deletion on 17p12, at 14.0–15.4 Mb. The latter is known to cause hereditary neuropathy with liability to pressure palsies. The same deletion was found in 6 of 4618 (0.13%) cases and 6 of 36 092 (0.017%) controls in the re-analysed data of two recent large CNV studies of schizophrenia (OR = 7.82, P = 0.001), with the combined significance level for all three studies achieving P = 5 × 10−5. One large duplication on 16p13.1, which has been previously implicated as a susceptibility factor for autism, was found in three cases and six controls (0.6% versus 0.2%, OR = 2.98, P = 0.13). We also provide the first support for a recently reported association between deletions at 15q11.2 and schizophrenia (P = 0.026). This study confirms the involvement of rare CNVs in the pathogenesis of schizophrenia and contributes to the growing list of specific CNVs that are implicated.

Navigating buildings in "desk-top" virtual environments: Experimental investigations using extended navigational experience.

Abstract: Participants learned the layout of large-scale "virtual buildings" through extended navigational experience, using "desk-top" (i.e., nonimmersive) virtual environments (VEs). Experiment 1 recreated a study performed in a real building (P. W. Thorndyke & B. Hayes-Roth, 1982). After overcoming initial disorientation, participants ultimately developed near-perfect routefinding abilities. Their ability to judge directions and relative distances was similar to that found with the real building. Two further experiments investigated the effect of localized landmarks. Colored patterns had no effect on participants' route-finding accuracy. However, participants were more accurate in their route finding when familiar objects were used as landmarks than when no landmarks were used. The implications of the findings for the design of VEs are discussed. Virtual environment (VE) systems are being