Institution
Cardiff University
Education•Cardiff, United Kingdom•
About: Cardiff University is a education organization based out in Cardiff, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 34188 authors who have published 82643 publications receiving 3046531 citations. The organization is also known as: University of Cardiff & University College of South Wales and Monmouthshire.
Topics: Population, Context (language use), Catalysis, Galaxy, Poison control
Papers published on a yearly basis
Papers
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TL;DR: The work described here was intended to add to present theoretical knowledge of stability in large systems, for instability usually appears as a self-generating catastrophe.
Abstract: MANY systems being studied today are dynamic, large and complex: traffic at an airport with 100 planes, slum areas with 104 persons or the human brain with 1010 neurones. In such systems, stability is of central importance, for instability usually appears as a self-generating catastrophe. Unfortunately, present theoretical knowledge of stability in large systems is meagre: the work described here was intended to add to it.
711 citations
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TL;DR: The environmental and microbiological factors that can influence heavy metal toxicity are discussed with a view to understanding the mechanisms of microbial metal tolerance.
Abstract: The environmental and microbiological factors that can influence heavy metal toxicity are discussed with a view to understanding the mechanisms of microbial metal tolerance. It is apparent that metal toxicity can be heavily influenced by environmental conditions. Binding of metals to organic materials, precipitation, complexation, and ionic interactions are all important phenomena that must be considered carefully in laboratory and field studies. It is also obvious that microbes possess a range of tolerance mechanisms, most featuring some kind of detoxification. Many of these detoxification mechanisms occur widely in the microbial world and are not only specific to microbes growing in metal-contaminated environments.
710 citations
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TL;DR: This review examines the current understanding of the molecular genetics of colorectal carcinogenesis and concludes that gastroenterologists have a working knowledge of the pathological mechanisms that drive the disease.
Abstract: Colorectal cancer is a common but heterogeneous disease, which arises through the accumulation of genetic mutations Knowledge of the molecular basis of colorectal cancer has advanced at a rapid pace in recent years, reflecting progress made in the field of genomic medicine Targeted therapies have come into mainstream use, and the exciting prospect of treatment regimens tailored to the mutation profile of individual tumours is beginning to emerge In order to understand the development and application of the next generation of colorectal cancer treatments, it is important that gastroenterologists have a working knowledge of the pathological mechanisms that drive the disease This review examines our current understanding of the molecular genetics of colorectal carcinogenesis
708 citations
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University of Sussex1, Jet Propulsion Laboratory2, California Institute of Technology3, European Space Agency4, Ames Research Center5, University of Edinburgh6, Paris Diderot University7, Imperial College London8, Aix-Marseille University9, Cornell University10, Spanish National Research Council11, University of La Laguna12, Complutense University of Madrid13, UK Astronomy Technology Centre14, University of Colorado Boulder15, University of California, Irvine16, Goddard Space Flight Center17, University of Nottingham18, Cardiff University19, University of Padua20, Institut d'Astrophysique de Paris21, University of Cambridge22, University of British Columbia23, European Space Research and Technology Centre24, University of Manchester25, University College London26, Rutherford Appleton Laboratory27, University of Lethbridge28, University of Oxford29, Commonwealth Scientific and Industrial Research Organisation30, University of Hertfordshire31, Harvard University32
TL;DR: The Herschel Multi-tiered Extragalactic Survey (HerMES) is a legacy program designed to map a set of nested fields totalling ~380 deg^2 as mentioned in this paper.
Abstract: The Herschel Multi-tiered Extragalactic Survey, HerMES, is a legacy program designed to map a set of nested fields totalling ~380 deg^2. Fields range in size from 0.01 to ~20 deg^2, using Herschel-SPIRE (at 250, 350 and 500 \mu m), and Herschel-PACS (at 100 and 160 \mu m), with an additional wider component of 270 deg^2 with SPIRE alone. These bands cover the peak of the redshifted thermal spectral energy distribution from interstellar dust and thus capture the re-processed optical and ultra-violet radiation from star formation that has been absorbed by dust, and are critical for forming a complete multi-wavelength understanding of galaxy formation and evolution.
The survey will detect of order 100,000 galaxies at 5\sigma in some of the best studied fields in the sky. Additionally, HerMES is closely coordinated with the PACS Evolutionary Probe survey. Making maximum use of the full spectrum of ancillary data, from radio to X-ray wavelengths, it is designed to: facilitate redshift determination; rapidly identify unusual objects; and understand the relationships between thermal emission from dust and other processes. Scientific questions HerMES will be used to answer include: the total infrared emission of galaxies; the evolution of the luminosity function; the clustering properties of dusty galaxies; and the properties of populations of galaxies which lie below the confusion limit through lensing and statistical techniques.
This paper defines the survey observations and data products, outlines the primary scientific goals of the HerMES team, and reviews some of the early results.
707 citations
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TL;DR: Fibrocartilage is a dynamic tissue that disappears when the tendons are rerouted surgically and can be maintained in vitro when discs of tendon are compressed, but at some locations fibrocartilaginous is a sign of pathology.
Abstract: Where tendons and ligaments are subject to compression, they are frequently fibrocartilaginous. This occurs at 2 principal sites: where tendons (and sometimes ligaments) wrap around bony or fibrous pulleys, and in the region where they attach to bone, i.e. at their entheses. Wrap-around tendons are most characteristic of the limbs and are commonly wider at their point of bony contact so that the pressure is reduced. The most fibrocartilaginous tendons are heavily loaded and permanently bent around their pulleys. There is often pronounced interweaving of collagen fibres that prevents the tendons from splaying apart under compression. The fibrocartilage can be located within fascicles, or in endo- or epitenon (where it may protect blood vessels from compression or allow fascicles to slide). Fibrocartilage cells are commonly packed with intermediate filaments which could be involved in transducing mechanical load. The ECM often contains aggrecan which allows the tendon to imbibe water and withstand compression. Type II collagen may also be present, particularly in tendons that are heavily loaded. Fibrocartilage is a dynamic tissue that disappears when the tendons are rerouted surgically and can be maintained in vitro when discs of tendon are compressed. Finite element analyses provide a good correlation between its distribution and levels of compressive stress, but at some locations fibrocartilage is a sign of pathology. Enthesis fibrocartilage is most typical of tendons or ligaments that attach to the epiphyses of long bones where it may also be accompanied by sesamoid and periosteal fibrocartilages. It is characteristic of sites where the angle of attachment changes throughout the range of joint movement and it reduces wear and tear by dissipating stress concentration at the bony interface. There is a good correlation between the distribution of fibrocartilage within an enthesis and the levels of compressive stress. The complex interlocking between calcified fibrocartilage and bone contributes to the mechanical strength of the enthesis and cartilage-like molecules (e.g. aggrecan and type II collagen) in the ECM contribute to its ability to withstand compression. Pathological changes are common and are known as enthesopathies.
705 citations
Authors
Showing all 34629 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rob Knight | 201 | 1061 | 253207 |
Stephen V. Faraone | 188 | 1427 | 140298 |
John J.V. McMurray | 178 | 1389 | 184502 |
David R. Williams | 178 | 2034 | 138789 |
John Hardy | 177 | 1178 | 171694 |
Dorret I. Boomsma | 176 | 1507 | 136353 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Anders Björklund | 165 | 769 | 84268 |
Edward T. Bullmore | 165 | 746 | 112463 |
Peter A. R. Ade | 162 | 1387 | 138051 |
Michael John Owen | 160 | 1110 | 135795 |
Gavin Davies | 159 | 2036 | 149835 |
Suvadeep Bose | 154 | 960 | 129071 |
Todd Adams | 154 | 1866 | 143110 |
John R. Hodges | 149 | 812 | 82709 |