Cardiff University

About: Cardiff University is a education organization based out in Cardiff, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 34188 authors who have published 82643 publications receiving 3046531 citations. The organization is also known as: University of Cardiff & University College of South Wales and Monmouthshire.

Hormonal impact of the 17 alpha-hydroxylase/C-17,C-20-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer

Abstract: Hormonal impact of the 17 α -hydroxylase/C 17,20 -lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer

On the Cosmic Origins of Carbon and Nitrogen

Abstract: We analyze the behavior of N/O and C/O abundance ratios as a function of metallicity as gauged by O/H in large, extant Galactic and extragalactic H II region abundance samples. We compile and compare published yields of C, N, and O for intermediate mass and massive stars and choose appropriate yield sets based on analytical chemical evolution models fitted to the abundance data. We then use these yields to compute numerical chemical evolution models that satisfactorily reproduce the observed abundance trends and thereby identify the most likely production sites for carbon and nitrogen. Our results suggest that carbon and nitrogen originate from separate production sites and are decoupled from one another. Massive stars (M > 8 M☉) dominate the production of carbon, while intermediate-mass stars between 4 and 8 M☉, with a characteristic lag time of roughly 250 Myr following their formation, dominate nitrogen production. Carbon production is positively sensitive to metallicity through mass-loss processes in massive stars and has a pseudo-secondary character. Nitrogen production in intermediate mass stars is primary at low metallicity, but when 12 + log(O/H) > 8.3, secondary nitrogen becomes prominent, and nitrogen increases at a faster rate than oxygen—indeed, the dependence is steeper than would be formally expected for a secondary element. The observed flat behavior of N/O versus O/H in metal-poor galaxies is explained by invoking low star formation rates that flatten the age-metallicity relation and allow N/O to rise to observed levels at low metallicities. The observed scatter and distribution of data points for N/O challenge the popular idea that observed intermittent polluting by oxygen is occurring from massive stars following star bursts. Rather, we find most points cluster at relatively low N/O values, indicating that scatter is caused by intermittent increases in nitrogen caused by local contamination by Wolf-Rayet stars or luminous blue variables. In addition, the effect of inflow of gas into galactic systems on secondary production of nitrogen from carbon may introduce some scatter into N/O ratios at high metallicities.

Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1

Abstract: Complement is an ancient danger-sensing system that contributes to host defense, immune surveillance and homeostasis1. C5a and its G protein–coupled receptor mediate many of the proinflammatory properties of complement2. Despite the key role of C5a in allergic asthma3, autoimmune arthritis4, sepsis5 and cancer6, knowledge about its regulation is limited. Here we demonstrate that IgG1 immune complexes (ICs), the inhibitory IgG receptor FcγRIIB and the C-type lectin–like receptor dectin-1 suppress C5a receptor (C5aR) functions. IgG1 ICs promote the association of FcγRIIB with dectin-1, resulting in phosphorylation of Src homology 2 domain–containing inositol phosphatase (SHIP) downstream of FcγRIIB and spleen tyrosine kinase downstream of dectin-1. This pathway blocks C5aR-mediated ERK1/2 phosphorylation, C5a effector functions in vitro and C5a-dependent inflammatory responses in vivo, including peritonitis and skin blisters in experimental epidermolysis bullosa acquisita. Notably, high galactosylation of IgG N-glycans is crucial for this inhibitory property of IgG1 ICs, as it promotes the association between FcγRIIB and dectin-1. Thus, galactosylated IgG1 and FcγRIIB exert anti-inflammatory properties beyond their impact on activating FcγRs.