Institution
Clinical Trial Service Unit
About: Clinical Trial Service Unit is a based out in . It is known for research contribution in the topics: Population & Stroke. The organization has 428 authors who have published 1387 publications receiving 181920 citations.
Papers published on a yearly basis
Papers
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TL;DR: Exposure of the heart to ionizing radiation during radiotherapy for breast cancer increases the subsequent rate of ischemic heart disease, and the increase is proportional to the mean dose to the heart, begins within a few years after exposure, and continues for at least 20 years.
Abstract: Background Radiotherapy for breast cancer often involves some incidental exposure of the heart to ionizing radiation. The effect of this exposure on the subsequent risk of ischemic heart disease is uncertain. Methods We conducted a population-based case-control study of major coronary events (i.e., myocardial infarction, coronary revascularization, or death from ischemic heart disease) in 2168 women who underwent radiotherapy for breast cancer between 1958 and 2001 in Sweden and Denmark; the study included 963 women with major coronary events and 1205 controls. Individual patient information was obtained from hospital records. For each woman, the mean radiation doses to the whole heart and to the left anterior descending coronary artery were estimated from her radiotherapy chart. Results The overall average of the mean doses to the whole heart was 4.9 Gy (range, 0.03 to 27.72). Rates of major coronary events increased linearly with the mean dose to the heart by 7.4% per gray (95% confidence interval, 2.9 to 14.5; P Conclusions Exposure of the heart to ionizing radiation during radiotherapy for breast cancer increases the subsequent rate of ischemic heart disease. The increase is proportional to the mean dose to the heart, begins within a few years after exposure, and continues for at least 20 years. Women with preexisting cardiac risk factors have greater absolute increases in risk from radiotherapy than other women. (Funded by Cancer Research UK and others.).
2,885 citations
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TL;DR: The statistical models used used to estimate incidence and mortality data for 25 cancers in 40 European countries in 2008 used to obtain an estimate of the numbers of cancer cases and deaths in Europe in 2008.
2,358 citations
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TL;DR: In this article, a systematic review and meta-analysis of large-scale blood pressure lowering trials, published between Jan 1, 1966, and July 7, 2015, was performed.
2,296 citations
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Clinical Trial Service Unit1, University College London2, North Bristol NHS Trust3, University of Würzburg4, The George Institute for Global Health5, Children's Hospital at Westmead6, Peking Union Medical College7, Sultanah Aminah Hospital8, University of British Columbia9, National Institutes of Health10, Brigham and Women's Hospital11, University of Minnesota12, University of Otago13, University of Picardie Jules Verne14, University of Copenhagen15, Chiang Mai University16, Oslo University Hospital17, Charles University in Prague18, Medical University of Silesia19, Utrecht University20, University Medical Center Groningen21, University of Helsinki22, John Radcliffe Hospital23
TL;DR: Reduction of LDL cholesterol with simvastatin 20 mg plus ezetimibe 10 mg daily safely reduced the incidence of major atherosclerotic events in a wide range of patients with advanced chronic kidney disease.
2,123 citations
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TL;DR: The published results from these prospective studies are remarkably consistent for each factor, indicating moderate but highly statistically significant associations with CHD, even though mechanisms that might account for these associations are not clear.
Abstract: Context.—A large number of epidemiologic studies have reported on associations
between various "inflammatory" factors and coronary heart disease (CHD).Objective.—To assess the associations of blood levels of fibrinogen, C-reactive
protein (CRP), and albumin and leukocyte count with the subsequent risk of
CHD.Data Sources.—Meta-analyses of any long-term prospective studies of CHD published
before 1998 on any of these 4 factors. Studies were identified by MEDLINE
searches, scanning of relevant reference lists, hand searching of cardiology,
epidemiology, and other relevant journals, and discussions with authors of
relevant reports.Study Selection.—All relevant studies identified were included.Data Extraction.—The following information was abstracted from published reports (supplemented,
in several cases, by the authors): size and type of cohort, mean age, mean
duration of follow-up, assay methods, degree of adjustment for confounders,
and relationship of CHD risk to the baseline assay results.Data Synthesis.—For fibrinogen, with 4018 CHD cases in 18 studies, comparison of individuals
in the top third with those in the bottom third of the baseline measurements
yielded a combined risk ratio of 1.8 (95% confidence interval [CI], 1.6-2.0)
associated with a difference in long-term usual mean fibrinogen levels of
2.9 µmol/L (0.1 g/dL) between the top and bottom thirds (10.3 vs 7.4
µmol/L [0.35 vs 0.25 g/dL]). For CRP, with 1053 CHD cases in 7 studies,
the combined risk ratio of 1.7 (95% CI, 1.4-2.1) was associated with a difference
of 1.4 mg/L (2.4 vs 1.0 mg/L). For albumin, with 3770 CHD cases in 8 studies,
the combined risk ratio of 1.5 (95% CI, 1.3-1.7) was associated with a difference
of 4 g/L (38 vs 42 g/L, ie, an inverse association). For leukocyte count,
with 5337 CHD cases in the 7 largest studies, the combined risk ratio of 1.4
(95% CI, 1.3-1.5) was associated with a difference of 2.8×109/L
(8.4 vs 5.6×109/L). Each of these overall results was highly
significant (P<.0001).Conclusions.—The published results from these prospective studies are remarkably
consistent for each factor, indicating moderate but highly statistically significant
associations with CHD. Hence, even though mechanisms that might account for
these associations are not clear, further study of the relevance of these
factors to the causation of CHD is warranted.
2,089 citations
Authors
Showing all 428 results
Name | H-index | Papers | Citations |
---|---|---|---|
Salim Yusuf | 231 | 1439 | 252912 |
Richard Peto | 183 | 683 | 231434 |
Cornelia M. van Duijn | 183 | 1030 | 146009 |
Rory Collins | 162 | 489 | 193407 |
Naveed Sattar | 155 | 1326 | 116368 |
Timothy J. Key | 146 | 808 | 90810 |
John Danesh | 135 | 394 | 100132 |
Andrew J.S. Coats | 127 | 820 | 94490 |
Valerie Beral | 114 | 471 | 53729 |
Mike Clarke | 113 | 1037 | 164328 |
Robert Clarke | 111 | 512 | 90049 |
Robert U. Newton | 109 | 753 | 42527 |
Richard Gray | 109 | 808 | 78580 |
Braxton D. Mitchell | 102 | 558 | 49599 |
Naomi E. Allen | 101 | 364 | 37057 |