Institution
Erasmus University Medical Center
Healthcare•Rotterdam, Zuid-Holland, Netherlands•
About: Erasmus University Medical Center is a healthcare organization based out in Rotterdam, Zuid-Holland, Netherlands. It is known for research contribution in the topics: Population & Medicine. The organization has 8162 authors who have published 11395 publications receiving 517117 citations.
Topics: Population, Medicine, Cancer, Transplantation, Breast cancer
Papers published on a yearly basis
Papers
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Radboud University Nijmegen Medical Centre1, Erasmus University Medical Center2, Goethe University Frankfurt3, Maastricht University Medical Centre4, Royal London Hospital5, Manchester Royal Infirmary6, Cliniques Universitaires Saint-Luc7, Karolinska University Hospital8, Boston Children's Hospital9, National Health Service10, Helsinki University Central Hospital11, Medical University of Vienna12, Utrecht University13, Sapienza University of Rome14, Royal Adelaide Hospital15, University Medical Center Groningen16, Katholieke Universiteit Leuven17, Leiden University18, Royal Free Hospital19
TL;DR: The INSIGHT study analyzed the association between F8 mutation and inhibitor development in patients with nonsevere hemophilia A and found that among a total of 214 different F8 missense mutations 19 were associated with inhibitor development.
183 citations
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Wellcome Trust Sanger Institute1, European Bioinformatics Institute2, University of Queensland3, University of Edinburgh4, Max Planck Society5, Technische Universität München6, King's College London7, University of Basel8, University Hospital Bonn9, University of Marburg10, Greifswald University Hospital11, Kaiser Permanente12, Stanford University13, University College London14, QIMR Berghofer Medical Research Institute15, VU University Amsterdam16, Aarhus University Hospital17, Lundbeck18, University of Liverpool19, Harvard University20, University of Lausanne21, Johns Hopkins University School of Medicine22, Broad Institute23, Heidelberg University24, Erasmus University Medical Center25, Dalhousie University26, Karolinska Institutet27, Columbia University28, Virginia Commonwealth University29, Semel Institute for Neuroscience and Human Behavior30
TL;DR: In this paper, the authors report differences in genetic architecture between depression defined by minimal phenotyping and strictly defined major depressive disorder (MDD): the former has a lower genotype-derived heritability that cannot be explained by inclusion of milder cases and a higher proportion of the genome contributing to this shared genetic liability with other conditions than for strictly defined MDD.
Abstract: Minimal phenotyping refers to the reliance on the use of a small number of self-reported items for disease case identification, increasingly used in genome-wide association studies (GWAS). Here we report differences in genetic architecture between depression defined by minimal phenotyping and strictly defined major depressive disorder (MDD): the former has a lower genotype-derived heritability that cannot be explained by inclusion of milder cases and a higher proportion of the genome contributing to this shared genetic liability with other conditions than for strictly defined MDD. GWAS based on minimal phenotyping definitions preferentially identifies loci that are not specific to MDD, and, although it generates highly predictive polygenic risk scores, the predictive power can be explained entirely by large sample sizes rather than by specificity for MDD. Our results show that reliance on results from minimal phenotyping may bias views of the genetic architecture of MDD and impede the ability to identify pathways specific to MDD.
182 citations
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TL;DR: Combination treatment with oral rifampicin and clindamycin is a promising treatment option for hidradenitis suppurativa, despite the frequent occurrence of diarrhea as a side effect.
Abstract: Background: A previous limited study showed promising results of combined oral treatment with rifampicin 600 mg and clindamycin 600 mg for 10 weeks. Objective: To expand and to validate the basis for this therapy, we reviewed the response to different treatment durations. Method: A retrospective study in 34 patients. Results: Twenty-eight of 34 patients (82%) experienced at least partial improvement, and 16 (47%) showed a total remission. The maximum effect of treatment appeared within 10 weeks. Following total remission, 8 of 13 (61.5%) patients treated as mentioned above experienced a relapse after a mean period of 5.0 months. Nonresponders were predominantly patients with severe disease. Conclusion: Combination treatment with oral rifampicin and clindamycin is a promising treatment option for hidradenitis suppurativa, despite the frequent occurrence of diarrhea as a side effect. The length and the dosage of treatment are not yet firmly established.
182 citations
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TL;DR: Ongoing advancements in treatment, and also improvement in other factors in the care of CRC patients—such as diagnostics, dedicated surgery and pre‐ and postoperative care—lead to a continuous improvement in the relative survival of CRC Patients.
Abstract: Regarding the continuous changes in the diagnostic process and treatment of colorectal cancer (CRC), it is important to evaluate long-term trends which are relevant in giving direction for further research and innovations in cancer patient care. The aim of this study was to analyze developments in incidence, treatment and survival for patients diagnosed with CRC in the Netherlands. For this population-based retrospective cohort study, all patients diagnosed with CRC between 1989 and 2014 in the Netherlands were identified using data of the nationwide population-based Netherlands Cancer Registry (n = 267,765), with follow-up until January 1, 2016. Analyses were performed for trends in incidence, mortality, stage distribution, treatment and relative survival measured from the time of diagnosis. The incidence of both colon and rectal cancer has risen. The use of postoperative chemotherapy for Stage III colon cancer increased (14–60%), as well as the use of preoperative (chemo)radiotherapy for rectal cancer (2–66%). The administration of systemic therapy and metastasectomy increased for Stage IV disease patients. The 5-year relative survival increased significantly from 53 to 62% for colon cancer and from 51 to 65% for rectal cancer. Ongoing advancements in treatment, and also improvement in other factors in the care of CRC patients—such as diagnostics, dedicated surgery and pre- and postoperative care—lead to a continuous improvement in the relative survival of CRC patients. The increasing incidence of CRC favors the implementation of the screening program, of which the effects should be monitored closely.
182 citations
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Bryn Mawr College1, University of Vermont2, University of Southern Denmark3, University of Montpellier4, Ghent University5, Catholic University of Portugal6, Babeș-Bolyai University7, University of Cologne8, University of New South Wales9, Ankara University10, Autonomous University of Barcelona11, Singapore Ministry of Health12, University of Minho13, University of Iceland14, National Taiwan University15, Vilnius University16, University of Pennsylvania17, The Chinese University of Hong Kong18, Yonsei University19, University of La Frontera20, Harran University21, Turku University Hospital22, Erasmus University Medical Center23, Katholieke Universiteit Leuven24, Hacettepe University25, University of Western Australia26
TL;DR: International comparisons were conducted of preschool children's behavioral and emotional problems as reported on the Child Behavior Checklist by parents in 24 societies, indicating that the rank orders of mean item ratings and internal consistencies of scales were very similar across diverse societies.
Abstract: International comparisons were conducted of preschool children's behavioral and emotional problems as reported on the Child Behavior Checklist for Ages 1½-5 by parents in 24 societies (N = 19,850). Item ratings were aggregated into scores on syndromes; Diagnostic and Statistical Manual of Mental Disorders-oriented scales; a Stress Problems scale; and Internalizing, Externalizing, and Total Problems scales. Effect sizes for scale score differences among the 24 societies ranged from small to medium (3-12%). Although societies differed greatly in language, culture, and other characteristics, Total Problems scores for 18 of the 24 societies were within 7.1 points of the omnicultural mean of 33.3 (on a scale of 0-198). Gender and age differences, as well as gender and age interactions with society, were all very small (effect sizes < 1%). Across all pairs of societies, correlations between mean item ratings averaged .78, and correlations between internal consistency alphas for the scales averaged .92, indicating that the rank orders of mean item ratings and internal consistencies of scales were very similar across diverse societies.
182 citations
Authors
Showing all 8309 results
Name | H-index | Papers | Citations |
---|---|---|---|
Albert Hofman | 267 | 2530 | 321405 |
André G. Uitterlinden | 199 | 1229 | 156747 |
Patrick W. Serruys | 186 | 2427 | 173210 |
Cornelia M. van Duijn | 183 | 1030 | 146009 |
Tien Yin Wong | 160 | 1880 | 131830 |
Monique M.B. Breteler | 159 | 546 | 93762 |
Marjo-Riitta Järvelin | 156 | 923 | 100939 |
Fernando Rivadeneira | 146 | 628 | 86582 |
Ewout W. Steyerberg | 139 | 1226 | 84896 |
J. Wouter Jukema | 124 | 785 | 61555 |
Bart W. Koes | 124 | 730 | 57630 |
Albert D. M. E. Osterhaus | 124 | 955 | 83678 |
Jan K. Buitelaar | 123 | 1004 | 61880 |
Frits R. Rosendaal | 122 | 763 | 69043 |
Johan P. Mackenbach | 120 | 783 | 56705 |