ETH Zurich

About: ETH Zurich is a education organization based out in Zurich, Switzerland. It is known for research contribution in the topics: Population & Computer science. The organization has 48393 authors who have published 122408 publications receiving 5111383 citations. The organization is also known as: Swiss Federal Institute of Technology in Zurich & Eidgenössische Technische Hochschule Zürich.

Impact of climate change on hydrological regimes and water resources management in the Rhine basin

Abstract: The International Commission for the Hydrology of the Rhine basin (CHR) hascarried out a researchproject to assess the impact of climate change on the river flow conditionsin the Rhine basin. Along abottom-up line, different detailed hydrological models with hourly and dailytime steps have beendeveloped for representative sub-catchments of the Rhine basin. Along atop-down line, a water balancemodel for the entire Rhine basin has been developed, which calculates monthlydischarges and which wastested on the scale of the major tributaries of the Rhine. Using this set ofmodels, the effects of climatechange on the discharge regime in different parts of the Rhine basin werecalculated using the results ofUKHI and XCCC GCM-experiments. All models indicate the same trends in thechanges: higher winterdischarge as a result of intensified snow-melt and increased winterprecipitation, and lower summerdischarge due to the reduced winter snow storage and an increase ofevapotranspiration. When the resultsare considered in more detail, however, several differences show up. These canfirstly be attributed todifferent physical characteristics of the studied areas, but different spatialand temporal scales used in themodelling and different representations of several hydrological processes(e.g., evapotranspiration,snow melt) are responsible for the differences found as well. Climate changecan affect various socio-economicsectors. Higher temperatures may threaten winter tourism in the lower wintersport areas. The hydrologicalchanges will increase flood risk during winter, whilst low flows during summerwill adversely affectinland navigation, and reduce water availability for agriculture and industry.Balancing the required actionsagainst economic cost and the existing uncertainties in the climate changescenarios, a policy of `no-regretand flexibility' in water management planning and design is recommended, whereanticipatory adaptivemeasures in response to climate change impacts are undertaken in combinationwith ongoing activities.

The MUSE second-generation VLT instrument

Abstract: Summary: The Multi Unit Spectroscopic Explorer (MUSE) is a second-generation VLT panoramic integral-field spectrograph currently in manufacturing, assembly and integration phase. MUSE has a field of 1x1 arcmin2 sampled at 0.2x0.2 arcsec2 and is assisted by the VLT ground layer adaptive optics ESO facility using four laser guide stars. The instrument is a large assembly of 24 identical high performance integral field units, each one composed of an advanced image slicer, a spectrograph and a 4kx4k detector. In this paper we review the progress of the manufacturing and report the performance achieved with the first integral field unit.

Coordinating Hundreds of Cooperative, Autonomous Vehicles in Warehouses

Abstract: The Kiva warehouse-management system creates a new paradigm for pick-pack-and-ship warehouses that significantly improves worker productivity. The Kiva system uses movable storage shelves that can be lifted by small, autonomous robots. By bringing the product to the worker, productivity is increased by a factor of two or more, while simultaneously improving accountability and flexibility. A Kiva installation for a large distribution center may require 500 or more vehicles. As such, the Kiva system represents the first commercially available, large-scale autonomous robot system. The first permanent installation of a Kiva system was deployed in the summer of 2006.

Minimum Information about a Biosynthetic Gene cluster.

Abstract: A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells

Abstract: The idea that conversion of glucose to ATP is an attractive target for cancer therapy has been supported in part by the observation that glucose deprivation induces apoptosis in rodent cells transduced with the proto-oncogene MYC, but not in the parental line. Here, we found that depletion of glucose killed normal human cells irrespective of induced MYC activity and by a mechanism different from apoptosis. However, depletion of glutamine, another major nutrient consumed by cancer cells, induced apoptosis depending on MYC activity. This apoptosis was preceded by depletion of the Krebs cycle intermediates, was prevented by two Krebs cycle substrates, but was unrelated to ATP synthesis or several other reported consequences of glutamine starvation. Our results suggest that the fate of normal human cells should be considered in evaluating nutrient deprivation as a strategy for cancer therapy, and that understanding how glutamine metabolism is linked to cell viability might provide new approaches for treatment of cancer.