Institution
ETH Zurich
Education•Zurich, Switzerland•
About: ETH Zurich is a education organization based out in Zurich, Switzerland. It is known for research contribution in the topics: Population & Computer science. The organization has 48393 authors who have published 122408 publications receiving 5111383 citations. The organization is also known as: Swiss Federal Institute of Technology in Zurich & Eidgenössische Technische Hochschule Zürich.
Topics: Population, Computer science, Catalysis, Context (language use), Laser
Papers published on a yearly basis
Papers
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TL;DR: The conditions under which partial melting of subducting oceanic crust occurs can be determined by combining a partial melting model for basaltic compositions with two-dimensional thermal models of subduction zones as discussed by the authors.
809 citations
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TL;DR: These findings demonstrate that by eliciting different cytokines C. albicans and S. aureus prime TH17 cells that produce either IFN-γ or IL-10, and identify IL-1β and IL-2 as pro- and anti-inflammatory regulators of TH17 Cells both at priming and in the effector phase.
Abstract: IL-17-producing CD4+ T helper cells (TH17) have been extensively investigated in mouse models of autoimmunity. However, the requirements for differentiation and the properties of pathogen-induced human TH17 cells remain poorly defined. Using an approach that combines the in vitro priming of naive T cells with the ex vivo analysis of memory T cells, we describe here two types of human TH17 cells with distinct effector function and differentiation requirements. Candida albicans-specific TH17 cells produced IL-17 and IFN-γ, but no IL-10, whereas Staphylococcus aureus-specific TH17 cells produced IL-17 and could produce IL-10 upon restimulation. IL-6, IL-23 and IL-1β contributed to TH17 differentiation induced by both pathogens, but IL-1β was essential in C. albicans-induced TH17 differentiation to counteract the inhibitory activity of IL-12 and to prime IL-17/IFN-γ double-producing cells. In addition, IL-1β inhibited IL-10 production in differentiating and in memory TH17 cells, whereas blockade of IL-1β in vivo led to increased IL-10 production by memory TH17 cells. We also show that, after restimulation, TH17 cells transiently downregulated IL-17 production through a mechanism that involved IL-2-induced activation of STAT5 and decreased expression of ROR-γt. Taken together these findings demonstrate that by eliciting different cytokines C. albicans and S. aureus prime TH17 cells that produce either IFN-γ or IL-10, and identify IL-1β and IL-2 as pro- and anti-inflammatory regulators of TH17 cells both at priming and in the effector phase.
809 citations
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TL;DR: This work shows that chalcogenide-based phase-change materials can be used to create an artificial neuron in which the membrane potential is represented by the phase configuration of the nanoscale phase- change device and shows that the temporal integration of postsynaptic potentials can be achieved on a nanosecond timescale.
Abstract: A nanoscale phase-change device can be used to create an artificial neuron that exhibits integrate-and-fire functionality with stochastic dynamics.
808 citations
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University of Göttingen1, University of Minnesota2, University of Jena3, University of Zurich4, University of Bern5, University of Potsdam6, Max Planck Society7, Helmholtz Centre for Environmental Research - UFZ8, Leipzig University9, Humboldt State University10, University of Cologne11, ETH Zurich12, Lüneburg University13, Tallinn University of Technology14, Imperial College London15, University of British Columbia16, American Museum of Natural History17
TL;DR: It is shown that plant diversity effects dampen with increasing trophic level and degree of omnivory, and the results suggest that plant Diversity has strong bottom-up effects on multitrophic interaction networks, with particularly strong effects on lower trophIC levels.
Abstract: Biodiversity is rapidly declining, and this may negatively affect ecosystem processes, including economically important ecosystem services Previous studies have shown that biodiversity has positive effects on organisms and processes across trophic levels However, only a few studies have so far incorporated an explicit food-web perspective In an eight-year biodiversity experiment, we studied an unprecedented range of above- and below-ground organisms and multitrophic interactions A multitrophic data set originating from a single long-term experiment allows mechanistic insights that would not be gained from meta-analysis of different experiments Here we show that plant diversity effects dampen with increasing trophic level and degree of omnivory This was true both for abundance and species richness of organisms Furthermore, we present comprehensive above-ground/below-ground biodiversity food webs Both above ground and below ground, herbivores responded more strongly to changes in plant diversity than did carnivores or omnivores Density and richness of carnivorous taxa was independent of vegetation structure Below-ground responses to plant diversity were consistently weaker than above-ground responses Responses to increasing plant diversity were generally positive, but were negative for biological invasion, pathogen infestation and hyperparasitism Our results suggest that plant diversity has strong bottom-up effects on multitrophic interaction networks, with particularly strong effects on lower trophic levels Effects on higher trophic levels are indirectly mediated through bottom-up trophic cascades
807 citations
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TL;DR: The authors used the HadGEM2-A general circulation model to simulate the effect of late twentieth century "global dimming" and associated increases in the diffuse radiation fraction on global carbon storage.
Abstract: Increased exposure to solar radiation generally increases plant photosynthesis, but not all forms of radiation are equally effective. In particular, field studies have demonstrated that a given amount of diffuse radiation leads to more fixed carbon than direct radiation. Mercado et al. use the HadGEM2-A general circulation model to simulate the effect of late twentieth century 'global dimming' and associated increases in the diffuse radiation fraction on global carbon storage. They find that increases in diffuse radiation enhanced the terrestrial carbon sink by about 25%. Paradoxically, reducing anthropogenic pollution in the future would reduce this diffuse radiation effect, thereby creating a positive feedback to global warming. More radiation generally increases vegetation photosynthesis, but field studies show that a given amount of diffuse radiation leads to more fixed carbon than direct radiation. Mercado and colleagues simulate the effect of late twentieth century increases in the diffuse radiation fraction, and find that the terrestrial carbon sink is enhanced by about 25% —paradoxically, reducing future anthropogenic pollution will reduce this diffuse radiation effect, creating a positive feedback to global warming. Plant photosynthesis tends to increase with irradiance. However, recent theoretical and observational studies have demonstrated that photosynthesis is also more efficient under diffuse light conditions1,2,3,4,5. Changes in cloud cover or atmospheric aerosol loadings, arising from either volcanic or anthropogenic emissions, alter both the total photosynthetically active radiation reaching the surface and the fraction of this radiation that is diffuse, with uncertain overall effects on global plant productivity and the land carbon sink. Here we estimate the impact of variations in diffuse fraction on the land carbon sink using a global model modified to account for the effects of variations in both direct and diffuse radiation on canopy photosynthesis. We estimate that variations in diffuse fraction, associated largely with the ‘global dimming’ period6,7,8, enhanced the land carbon sink by approximately one-quarter between 1960 and 1999. However, under a climate mitigation scenario for the twenty-first century in which sulphate aerosols decline before atmospheric CO2 is stabilized, this ‘diffuse-radiation’ fertilization effect declines rapidly to near zero by the end of the twenty-first century.
805 citations
Authors
Showing all 49062 results
Name | H-index | Papers | Citations |
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Ralph Weissleder | 184 | 1160 | 142508 |
Ruedi Aebersold | 182 | 879 | 141881 |
David L. Kaplan | 177 | 1944 | 146082 |
Andrea Bocci | 172 | 2402 | 176461 |
Richard H. Friend | 169 | 1182 | 140032 |
Lorenzo Bianchini | 152 | 1516 | 106970 |
David D'Enterria | 150 | 1592 | 116210 |
Andreas Pfeiffer | 149 | 1756 | 131080 |
Bernhard Schölkopf | 148 | 1092 | 149492 |
Martin J. Blaser | 147 | 820 | 104104 |
Sebastian Thrun | 146 | 434 | 98124 |
Antonio Lanzavecchia | 145 | 408 | 100065 |
Christoph Grab | 144 | 1359 | 144174 |
Kurt Wüthrich | 143 | 739 | 103253 |
Maurizio Pierini | 143 | 1782 | 104406 |