ETH Zurich

About: ETH Zurich is a education organization based out in Zurich, Switzerland. It is known for research contribution in the topics: Population & Computer science. The organization has 48393 authors who have published 122408 publications receiving 5111383 citations. The organization is also known as: Swiss Federal Institute of Technology in Zurich & Eidgenössische Technische Hochschule Zürich.

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

Abstract: The immune system influences the fate of developing cancers by not only functioning as a tumour promoter that facilitates cellular transformation, promotes tumour growth and sculpts tumour cell immunogenicity, but also as an extrinsic tumour suppressor that either destroys developing tumours or restrains their expansion. Yet, clinically apparent cancers still arise in immunocompetent individuals in part as a consequence of cancer-induced immunosuppression. In many individuals, immunosuppression is mediated by cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and programmed death-1 (PD-1), two immunomodulatory receptors expressed on T cells. Monoclonal-antibody-based therapies targeting CTLA-4 and/or PD-1 (checkpoint blockade) have yielded significant clinical benefits-including durable responses--to patients with different malignancies. However, little is known about the identity of the tumour antigens that function as the targets of T cells activated by checkpoint blockade immunotherapy and whether these antigens can be used to generate vaccines that are highly tumour-specific. Here we use genomics and bioinformatics approaches to identify tumour-specific mutant proteins as a major class of T-cell rejection antigens following anti-PD-1 and/or anti-CTLA-4 therapy of mice bearing progressively growing sarcomas, and we show that therapeutic synthetic long-peptide vaccines incorporating these mutant epitopes induce tumour rejection comparably to checkpoint blockade immunotherapy. Although mutant tumour-antigen-specific T cells are present in progressively growing tumours, they are reactivated following treatment with anti-PD-1 and/or anti-CTLA-4 and display some overlapping but mostly treatment-specific transcriptional profiles, rendering them capable of mediating tumour rejection. These results reveal that tumour-specific mutant antigens are not only important targets of checkpoint blockade therapy, but they can also be used to develop personalized cancer-specific vaccines and to probe the mechanistic underpinnings of different checkpoint blockade treatments.

Primary forests are irreplaceable for sustaining tropical biodiversity

Abstract: Human-driven land-use changes increasingly threaten biodiversity, particularly in tropical forests where both species diversity and human pressures on natural environments are high. The rapid conversion of tropical forests for agriculture, timber production and other uses has generated vast, human-dominated landscapes with potentially dire consequences for tropical biodiversity. Today, few truly undisturbed tropical forests exist, whereas those degraded by repeated logging and fires, as well as secondary and plantation forests, are rapidly expanding. Here we provide a global assessment of the impact of disturbance and land conversion on biodiversity in tropical forests using a meta-analysis of 138 studies. We analysed 2,220 pairwise comparisons of biodiversity values in primary forests (with little or no human disturbance) and disturbed forests. We found that biodiversity values were substantially lower in degraded forests, but that this varied considerably by geographic region, taxonomic group, ecological metric and disturbance type. Even after partly accounting for confounding colonization and succession effects due to the composition of surrounding habitats, isolation and time since disturbance, we find that most forms of forest degradation have an overwhelmingly detrimental effect on tropical biodiversity. Our results clearly indicate that when it comes to maintaining tropical biodiversity, there is no substitute for primary forests.

Processing Routes to Macroporous Ceramics: A Review

Abstract: Macroporous ceramics with pore sizes from 400 nm to 4 mm and porosity within the range 20%–97% have been produced for a number of well-established and emerging applications, such as molten metal filtration, catalysis, refractory insulation, and hot gas filtration. These applications take advantage of the unique properties achieved through the incorporation of macropores into solid ceramics. In this article, we review the main processing routes that can be used for the fabrication of macroporous ceramics with tailored microstructure and chemical composition. Emphasis is given to versatile and simple approaches that allow one to control the microstructural features that ultimately determine the properties of the macroporous material. Replica, sacrificial template, and direct foaming techniques are described and compared in terms of microstructures and mechanical properties that can be achieved. Finally, directions to future investigations on the processing of macroporous ceramics are proposed.

A 128 $\times$ 128 120 dB 15 $\mu$ s Latency Asynchronous Temporal Contrast Vision Sensor

Abstract: This paper describes a 128 times 128 pixel CMOS vision sensor. Each pixel independently and in continuous time quantizes local relative intensity changes to generate spike events. These events appear at the output of the sensor as an asynchronous stream of digital pixel addresses. These address-events signify scene reflectance change and have sub-millisecond timing precision. The output data rate depends on the dynamic content of the scene and is typically orders of magnitude lower than those of conventional frame-based imagers. By combining an active continuous-time front-end logarithmic photoreceptor with a self-timed switched-capacitor differencing circuit, the sensor achieves an array mismatch of 2.1% in relative intensity event threshold and a pixel bandwidth of 3 kHz under 1 klux scene illumination. Dynamic range is > 120 dB and chip power consumption is 23 mW. Event latency shows weak light dependency with a minimum of 15 mus at > 1 klux pixel illumination. The sensor is built in a 0.35 mum 4M2P process. It has 40times40 mum2 pixels with 9.4% fill factor. By providing high pixel bandwidth, wide dynamic range, and precisely timed sparse digital output, this silicon retina provides an attractive combination of characteristics for low-latency dynamic vision under uncontrolled illumination with low post-processing requirements.

EURO-CORDEX : new high-resolution climate change projections for European impact research

Abstract: A new high-resolution regional climate change ensemble has been established for Europe within the World Climate Research Program Coordinated Regional Downscaling Experiment (EURO-CORDEX) initiative. The first set of simulations with a horizontal resolution of 12.5 km was completed for the new emission scenarios RCP4.5 and RCP8.5 with more simulations expected to follow. The aim of this paper is to present this data set to the different communities active in regional climate modelling, impact assessment and adaptation. The EURO-CORDEX ensemble results have been compared to the SRES A1B simulation results achieved within the ENSEMBLES project. The large-scale patterns of changes in mean temperature and precipitation are similar in all three scenarios, but they differ in regional details, which can partly be related to the higher resolution in EURO-CORDEX. The results strengthen those obtained in ENSEMBLES, but need further investigations. The analysis of impact indices shows that for RCP8.5, there is a substantially larger change projected for temperature-based indices than for RCP4.5. The difference is less pronounced for precipitation-based indices. Two effects of the increased resolution can be regarded as an added value of regional climate simulations. Regional climate model simulations provide higher daily precipitation intensities, which are completely missing in the global climate model simulations, and they provide a significantly different climate change of daily precipitation intensities resulting in a smoother shift from weak to moderate and high intensities.