ICFO – The Institute of Photonic Sciences

About: ICFO – The Institute of Photonic Sciences is a facility organization based out in Barcelona, Spain. It is known for research contribution in the topics: Quantum & Quantum entanglement. The organization has 872 authors who have published 1965 publications receiving 56273 citations.

Plasmonics in Atomically Thin Crystalline Silver Films.

Abstract: Light–matter interaction at the atomic scale rules fundamental phenomena such as photoemission and lasing while enabling basic everyday technologies, including photovoltaics and optical communicati...

Synaptic phosphorylated α-synuclein in dementia with Lewy bodies

Abstract: Dementia with Lewy bodies is characterized by the accumulation of Lewy bodies and Lewy neurites in the CNS, both of which are composed mainly of aggregated α-synuclein phosphorylated at Ser129. Although phosphorylated α-synuclein is believed to exert toxic effects at the synapse in dementia with Lewy bodies and other α-synucleinopathies, direct evidence for the precise synaptic localization has been difficult to achieve due to the lack of adequate optical microscopic resolution to study human synapses. In the present study we applied array tomography, a microscopy technique that combines ultrathin sectioning of tissue with immunofluorescence allowing precise identification of small structures, to quantitatively investigate the synaptic phosphorylated α-synuclein pathology in dementia with Lewy bodies. We performed array tomography on human brain samples from five patients with dementia with Lewy bodies, five patients with Alzheimer's disease and five healthy control subjects to analyse the presence of phosphorylated α-synuclein immunoreactivity at the synapse and their relationship with synapse size. Main analyses were performed in blocks from cingulate cortex and confirmed in blocks from the striatum of cases with dementia with Lewy bodies. A total of 1 318 700 single pre- or postsynaptic terminals were analysed. We found that phosphorylated α-synuclein is present exclusively in dementia with Lewy bodies cases, where it can be identified in the form of Lewy bodies, Lewy neurites and small aggregates ( pre + post > postsynaptic) was observed. These results indicate that phosphorylated α-synuclein is found at the presynaptic terminals of dementia with Lewy bodies cases mainly in the form of small phosphorylated α-synuclein aggregates that are associated with changes in synaptic morphology. Overall, our data support the notion that pathological phosphorylated α-synuclein may disrupt the structure and function of the synapse in dementia with Lewy bodies.

General Method for Constructing Local Hidden Variable Models for Entangled Quantum States

Abstract: Entanglement allows for the nonlocality of quantum theory, which is the resource behind device-independent quantum information protocols. However, not all entangled quantum states display nonlocality. A central question is to determine the precise relation between entanglement and nonlocality. Here we present the first general test to decide whether a quantum state is local, and show that the test can be implemented by semidefinite programing. This method can be applied to any given state and for the construction of new examples of states with local hidden variable models for both projective and general measurements. As applications, we provide a lower-bound estimate of the fraction of two-qubit local entangled states and present new explicit examples of such states, including those that arise from physical noise models, Bell-diagonal states, and noisy Greenberger-Horne-Zeilinger and $W$ states.

Metastability of Quantum Droplet Clusters.

Abstract: We show that metastable ring-shaped clusters can be constructed from two-dimensional quantum droplets in systems described by the Gross-Pitaevskii equations augmented with Lee-Huang-Yang quantum corrections. The clusters exhibit dynamical behavior ranging from contraction to rotation with simultaneous periodic pulsations, or expansion, depending on the initial radius of the necklace pattern and phase shift between adjacent quantum droplets. We show that, using an energy-minimization analysis, one can predict equilibrium values of the cluster radius that correspond to rotation without radial pulsations. In such a regime, the clusters evolve as metastable states, withstanding abrupt variations in the underlying scattering lengths and keeping their azimuthal symmetry in the course of evolution, even in the presence of considerable perturbations.