Istanbul Technical University

About: Istanbul Technical University is a education organization based out in Istanbul, Turkey. It is known for research contribution in the topics: Fuzzy logic & Large Hadron Collider. The organization has 12889 authors who have published 25081 publications receiving 518242 citations. The organization is also known as: İstanbul Teknik Üniversitesi & Technical University of Istanbul.

Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants.

Abstract: Hypertension is an important factor in cardiovascular diseases. Angiotensin-I-converting enzyme (ACE) inhibitors like synthetic drugs are widely used to control hypertension. ACE-inhibitory peptides from food origins could be a good alternative to synthetic drugs. A number of plant-based peptides have been investigated for their potential ACE inhibitor activities by using in vitro and in vivo assays. These plant-based peptides can be obtained by solvent extraction, enzymatic hydrolysis with or without novel food processing methods, and fermentation. ACE-inhibitory activities of peptides can be affected by their structural characteristics such as chain length, composition and sequence. ACE-inhibitory peptides should have gastrointestinal stability and reach the cardiovascular system to show their bioactivity. This paper reviews the current literature on plant-derived ACE-inhibitory peptides including their sources, production and structure, as well as their activity by in vitro and in vivo studies and their bioavailability.

Tissue specialization at the metabolite level is perceived during the development of tomato fruit

Abstract: Fruit maturation and tissue differentiation are important topics in plant physiology. These biological phenomena are accompanied by specific alterations in the biological system, such as differences in the type and concentration of metabolites. The secondary metabolism of tomato (Solanum lycopersicum) fruit was monitored by using liquid chromatography (LC) coupled to photo-diode array (PDA) detection, fluorescence detection (FD), and mass spectrometry (MS). Through this integrated approach different classes of compounds were analysed: carotenoids, xanthophylls, chlorophylls, tocopherols, ascorbic acid, flavonoids, phenolic acids, glycoalkaloids, saponins, and other glycosylated derivatives. Related metabolite profiles of peel and flesh were found between several commercial tomato cultivars indicating similar metabolite trends despite the genetic background. For a single tomato cultivar, metabolite profiles of different fruit tissues (vascular attachment region, columella and placenta, epidermis, pericarp, and jelly parenchyma) were examined at the green, breaker, turning, pink, and red stages of fruit development. Unrelated to the chemical nature of the metabolites, behavioural patterns could be assigned to specific ripening stages or tissues. These findings suggest spatio-temporal specificity in the accumulation of endogenous metabolites from tomato fruit.

Multi-objective permutation flow shop scheduling problem: Literature review, classification and current trends

Abstract: The flow shop scheduling problem is finding a sequence given n jobs with same order at m machines according to certain performance measure(s). The job can be processed on at most one machine; meanwhile one machine can process at most one job. The most common objective for this problem is makespan. However, many real-world scheduling problems are multi-objective by nature. Over the years there have been several approaches used to deal with the multi-objective flow shop scheduling problems (MOFSP). Hence, in this study, we provide a brief literature review of the contributions to MOFSP and identify areas of opportunity for future research.