Istanbul Technical University

About: Istanbul Technical University is a education organization based out in Istanbul, Turkey. It is known for research contribution in the topics: Fuzzy logic & Large Hadron Collider. The organization has 12889 authors who have published 25081 publications receiving 518242 citations. The organization is also known as: İstanbul Teknik Üniversitesi & Technical University of Istanbul.

The North Anatolian fault in the Sea of Marmara

Abstract: [1] Using the detailed geometry and tectonics of the Main Marmara fault that connects the Gulf of Izmit fault with the Ganos fault established by Le Pichon et al. [2001] and the new GPS data set recently analyzed by Meade et al. [2002], we confirm the existence of a Marmara block delimited to the north by the northern branch of the North Anatolian fault (the Marmara branch) and to the south by the southern branch. The kinematics of this block indicate that the Marmara branch that crosses the Sea of Marmara is close to pure dextral strike slip at a rate of 23 mm/yr on its whole length. The short Cinarcik section is the only one where a significant extensional component is predicted. A simple kinematic model accounts for slip partitioning there, with 8–10 mm/yr of extension to the south of the basin and 23 mm/yr of dextral strike slip along the northern Cinarcik margin. The new GPS data demonstrate the existence of important asymmetric elastic loading along the Main Marmara fault that may have significant implications for the seismotectonics of the area. The expected future large earthquake may rupture the whole main Marmara fault. The partitioning in the Cinarcik basin may produce magnitude 7 normal faulting earthquakes if their repetition time is about 250 years. The 1896 earthquake may have been one of these normal fault earthquakes. The Marmara block is less than 1 Ma. Prior to its formation, it was part of the Anatolian block. At this time the Ganos fault was already a dextral strike-slip fault, but the fault system in the Sea of Marmara would have been affected by an extensional component increasing toward the east that accounts for the increasing size of the sedimentary basins eastward.

Insights on the Use of α-Lipoic Acid for Therapeutic Purposes

Abstract: α-lipoic acid (ALA, thioctic acid) is an organosulfur component produced from plants, animals, and humans. It has various properties, among them great antioxidant potential and is widely used as a racemic drug for diabetic polyneuropathy-associated pain and paresthesia. Naturally, ALA is located in mitochondria, where it is used as a cofactor for pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase complexes. Despite its various potentials, ALA therapeutic efficacy is relatively low due to its pharmacokinetic profile. Data suggests that ALA has a short half-life and bioavailability (about 30%) triggered by its hepatic degradation, reduced solubility as well as instability in the stomach. However, the use of various innovative formulations has greatly improved ALA bioavailability. The R enantiomer of ALA shows better pharmacokinetic parameters, including increased bioavailability as compared to its S enantiomer. Indeed, the use of amphiphilic matrices has capability to improve ALA bioavailability and intestinal absorption. Also, ALA’s liquid formulations are associated with greater plasma concentration and bioavailability as compared to its solidified dosage form. Thus, improved formulations can increase both ALA absorption and bioavailability, leading to a raise in therapeutic efficacy. Interestingly, ALA bioavailability will be dependent on age, while no difference has been found for gender. The present review aims to provide an updated on studies from preclinical to clinical trials assessing ALA’s usages in diabetic patients with neuropathy, obesity, central nervous system-related diseases and abnormalities in pregnancy.

Evidence for transverse-momentum- and pseudorapidity-dependent event-plane fluctuations in PbPb and pPb collisions

Abstract: A systematic study of the factorization of long-range azimuthal two-particle correlations into a product of single-particle anisotropies is presented as a function of pT and nu of both particles and as a function of the particle multiplicity in PbPb and pPb collisions. The data were taken with the CMS detector for PbPb collisions at root sNN = 2.76 TeV and pPb collisions at root sNN = 5.02 TeV, covering a very wide range of multiplicity. Factorization is observed to be broken as a function of both particle pT and nu. When measured with particles of different pT, the magnitude of the factorization breakdown for the second Fourier harmonic reaches 20% for very central PbPb collisions but decreases rapidly as the multiplicity decreases. The data are consistent with viscous hydrodynamic predictions, which suggest that the effect of factorization breaking is mainly sensitive to the initial-state conditions rather than to the transport properties (e.g., shear viscosity) of the medium. The factorization breakdown is also computed with particles of different nu. The effect is found to be weakest for mid-central PbPb events but becomes larger for more central or peripheral PbPb collisions, and also for very-high-multiplicity pPb collisions. The nu-dependent factorization data provide new insights to the longitudinal evolution of the medium formed in heavy ion collisions.