Leicester Royal Infirmary

About: Leicester Royal Infirmary is a healthcare organization based out in Leicester, United Kingdom. It is known for research contribution in the topics: Population & Carotid endarterectomy. The organization has 5300 authors who have published 6204 publications receiving 208464 citations.

Augmented Reduced-Intensity Regimen Does Not Improve Postallogeneic Transplant Outcomes in Acute Myeloid Leukemia.

Abstract: PURPOSEReduced-intensity conditioning (RIC) regimens have extended the curative potential of allogeneic stem-cell transplantation to older adults with high-risk acute myeloid leukemia (AML) and mye...

Common femoral artery Doppler wave-forms: a comparison of three methods of objective analysis with direct pressure measurements.

Abstract: Doppler maximum frequency wave-forms recorded from the femoral arteries of 50 patients with arterial disease have been submitted to three methods of objective analysis in an attempt to quantify the degree of proximal narrowing. The methods were compared with direct femoral artery pressure measurements at rest and during hyperaemia. There was marked overlap between the results of both pulsatility index and Laplace transform damping when compared with pressure assessment. Principal component analysis, however, produced significantly better agreement than Laplace transform damping (chi 2 = 5.8, P less than 0.02) and in addition was found to be sensitive to the presence or absence of disease in the superficial femoral artery. Principal component analysis appears to be the most powerful method of Doppler wave-form analysis so far described and may have a place in the non-invasive assessment of the aorto-iliac segment.

Role of sequential leucocyte counts and C-reactive protein measurements in acute appendicitis.

Abstract: The accurate clinical diagnosis of acute appendicitis is difficult, and many techniques have been suggested to improve diagnostic accuracy such as laparoscopy, ultrasonography and barium enema examination. In this study serial total leucocyte counts and serial C-reactive protein (CRP) concentrations in acute appendicitis were measured. The sensitivity and specificity of serial leucocyte counts in acute appendicitis were 92 and 100 per cent, and for CRP concentrations 69 and 75 per cent, respectively. The sensitivity and specificity of serial total leucocyte counts fulfilled the criteria for a diagnostic test. It is suggested that in patients with equivocal clinical findings, clinical observation combined with serial leucocyte counts may improve decision making.

Analgesia for circumcision in a paediatric population: Comparison of caudal bupivacaine alone with bupivacaine plus two doses of clonidine

Abstract: BACKGROUND Clonidine is often used to improve the duration and quality of analgesia produced by caudal epidural blockade, although the optimum dose of clonidine with bupivacaine remains uncertain. METHODS We compared the effect of clonidine, 1 and 2 microg x kg(-1), added to bupivacaine (1.25 mg x kg(-1)) with that of bupivacaine alone in 75 male children undergoing elective circumcision. RESULTS There was a trend towards increasing duration of analgesia with increasing dose of clonidine [group B (bupivacaine) 280.7 (171.6) min, C1 (bupivacaine + clonidine 1 microg x kg(-1)) 327.8 (188.3) min and C2 (bupivacaine + clonidine 2 microg x kg(-1)) 382.0 (200.6) min], although this difference was not statistically significant. Mean time to arousal from anaesthesia was significantly prolonged with clonidine 2 microg kg(-1) (group C2 21.3 (13-36) min, group C1 14.0 (6-25) min and group B 14.4 (2-32) min. Supplementary analgesic requirements and incidence of adverse effects were low, with no differences between the groups. CONCLUSIONS For paediatric circumcision, under general anaesthesia, the addition of clonidine 2 microg x kg(-1) to low volume (0.5 ml x kg(-1)) caudal anaesthetics has a limited clinical benefit for children undergoing circumcision.