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Yu Ru Su
Researcher at Fred Hutchinson Cancer Research Center
Publications - 13
Citations - 741
Yu Ru Su is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Genome-wide association study & Odds ratio. The author has an hindex of 8, co-authored 12 publications receiving 358 citations. Previous affiliations of Yu Ru Su include University of Virginia.
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Journal ArticleDOI
Discovery of common and rare genetic risk variants for colorectal cancer
Jeroen R. Huyghe,Stephanie A. Bien,Tabitha A. Harrison,Hyun Min Kang,Sai Chen,Stephanie L. Schmit,David V. Conti,Conghui Qu,Jihyoun Jeon,Christopher K. Edlund,Peyton Greenside,Michael Wainberg,Fredrick R. Schumacher,Joshua D. Smith,David M. Levine,Sarah C. Nelson,Nasa Sinnott-Armstrong,Demetrius Albanes,M. Henar Alonso,Kristin E. Anderson,Coral Arnau-Collell,Volker Arndt,Christina Bamia,Barbara L. Banbury,John A. Baron,Sonja I. Berndt,Stéphane Bézieau,D. Timothy Bishop,Juergen Boehm,Heiner Boeing,Hermann Brenner,Stefanie Brezina,Stephan Buch,Daniel D. Buchanan,Daniel D. Buchanan,Andrea N. Burnett-Hartman,Katja Butterbach,Bette J. Caan,Peter T. Campbell,Christopher S. Carlson,Christopher S. Carlson,Sergi Castellví-Bel,Andrew T. Chan,Andrew T. Chan,Jenny Chang-Claude,Jenny Chang-Claude,Stephen J. Chanock,Maria Dolores Chirlaque,Sang-Hee Cho,Charles M. Connolly,Amanda J. Cross,Katarina Cuk,Keith R. Curtis,Albert de la Chapelle,Kimberly F. Doheny,David Duggan,Douglas F. Easton,Sjoerd G. Elias,Faye Elliott,Dallas R. English,Dallas R. English,Edith J. M. Feskens,Jane C. Figueiredo,Jane C. Figueiredo,Rocky Fischer,Liesel M. FitzGerald,Liesel M. FitzGerald,David Forman,Manish Gala,Steven Gallinger,W. James Gauderman,Graham G. Giles,Graham G. Giles,Elizabeth M. Gillanders,Jian Gong,Phyllis J. Goodman,William M. Grady,John S. Grove,Andrea Gsur,Marc J. Gunter,Robert W. Haile,Jochen Hampe,Heather Hampel,Sophia Harlid,Richard B. Hayes,Philipp Hofer,Michael Hoffmeister,John L. Hopper,John L. Hopper,Wan-Ling Hsu,Wen Yi Huang,Thomas J. Hudson,David J. Hunter,David J. Hunter,Gemma Ibáñez-Sanz,Gregory Idos,Roxann G. Ingersoll,Rebecca D. Jackson,Eric J. Jacobs,Mark A. Jenkins,Amit Joshi,Corinne E. Joshu,Temitope O. Keku,Timothy J. Key,Hyeong Rok Kim,Emiko Kobayashi,Laurence N. Kolonel,Charles Kooperberg,Tilman Kühn,Sébastien Küry,Sun-Seog Kweon,Susanna C. Larsson,Cecelia A. Laurie,Loic Le Marchand,Suzanne M. Leal,Soo-Chin Lee,Flavio Lejbkowicz,Mathieu Lemire,Christopher I. Li,Li Li,Wolfgang Lieb,Yi Lin,Annika Lindblom,Noralane M. Lindor,Hua Ling,Tin Louie,Satu Männistö,Sanford D. Markowitz,Vicente Martín,Giovanna Masala,Caroline McNeil,Marilena Melas,Roger L. Milne,Roger L. Milne,Lorena Moreno,Neil Murphy,Robin Myte,Alessio Naccarati,Polly A. Newcomb,Polly A. Newcomb,Kenneth Offit,Kenneth Offit,Shuji Ogino,Shuji Ogino,N. Charlotte Onland-Moret,Barbara Pardini,Patrick S. Parfrey,Rachel Pearlman,Vittorio Perduca,Vittorio Perduca,Paul D.P. Pharoah,Mila Pinchev,Elizabeth A. Platz,Ross L. Prentice,Elizabeth W. Pugh,Leon Raskin,Gad Rennert,Gad Rennert,Hedy S. Rennert,Hedy S. Rennert,Elio Riboli,Miguel Rodríguez-Barranco,Jane Romm,Lori C. Sakoda,Lori C. Sakoda,Clemens Schafmayer,Robert E. Schoen,Daniela Seminara,Mitul Shah,Tameka Shelford,Min-Ho Shin,Katerina Shulman,Sabina Sieri,Martha L. Slattery,Melissa C. Southey,Zsofia K. Stadler,Christa Stegmaier,Yu Ru Su,Catherine M. Tangen,Stephen N. Thibodeau,Duncan C. Thomas,Sushma S. Thomas,Amanda E. Toland,Antonia Trichopoulou,Cornelia M. Ulrich,David Van Den Berg,Fränzel J.B. Van Duijnhoven,Bethany Van Guelpen,Henk J. van Kranen,Joseph Vijai,Kala Visvanathan,Pavel Vodicka,Pavel Vodicka,Ludmila Vodickova,Ludmila Vodickova,Veronika Vymetalkova,Veronika Vymetalkova,Korbinian Weigl,Korbinian Weigl,Stephanie J. Weinstein,Emily White,Aung Ko Win,Aung Ko Win,C. Roland Wolf,Alicja Wolk,Alicja Wolk,Michael O. Woods,Anna H. Wu,Syed H.E. Zaidi,Brent W. Zanke,Qing Zhang,Wei Zheng,Peter C. Scacheri,John D. Potter,Michael C. Bassik,Anshul Kundaje,Graham Casey,Victor Moreno,Gonçalo R. Abecasis,Deborah A. Nickerson,Stephen B. Gruber,Li Hsu,Li Hsu,Ulrike Peters,Ulrike Peters +224 more
TL;DR: Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.
Journal ArticleDOI
Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk.
Minta Thomas,Lori C. Sakoda,Michael Hoffmeister,Elisabeth A. Rosenthal,Jeffrey K. Lee,Fränzel J.B. Van Duijnhoven,Elizabeth A. Platz,Anna H. Wu,Christopher H. Dampier,Albert de la Chapelle,Alicja Wolk,Amit Joshi,Andrea N. Burnett-Hartman,Andrea Gsur,Annika Lindblom,Antoni Castells,Aung Ko Win,Bahram Namjou,Bethany Van Guelpen,Catherine M. Tangen,Qianchuan He,Christopher I. Li,Clemens Schafmayer,Corinne E. Joshu,Cornelia M. Ulrich,D. Timothy Bishop,Daniel D. Buchanan,Daniel J. Schaid,David A. Drew,David C. Muller,David Duggan,David R. Crosslin,Demetrius Albanes,Edward Giovannucci,Eric B. Larson,Flora Qu,Frank D. Mentch,Graham G. Giles,Hakon Hakonarson,Heather Hampel,Ian B. Stanaway,Jane C. Figueiredo,Jeroen R. Huyghe,Jessica Minnier,Jenny Chang-Claude,Jenny Chang-Claude,Jochen Hampe,John B. Harley,Kala Visvanathan,Keith R. Curtis,Kenneth Offit,Li Li,Loic Le Marchand,Ludmila Vodickova,Marc J. Gunter,Mark A. Jenkins,Martha L. Slattery,Mathieu Lemire,Michael O. Woods,Mingyang Song,Neil Murphy,Noralane M. Lindor,Ozan Dikilitas,Paul D.P. Pharoah,Peter T. Campbell,Polly A. Newcomb,Polly A. Newcomb,Roger L. Milne,Robert J. MacInnis,Sergi Castellví-Bel,Shuji Ogino,Sonja I. Berndt,Stéphane Bézieau,Stephen N. Thibodeau,Steven Gallinger,Syed H.E. Zaidi,Tabitha A. Harrison,Temitope O. Keku,Thomas J. Hudson,Veronika Vymetalkova,Victor Moreno,Vicente Martín,Volker Arndt,Wei-Qi Wei,Wendy K. Chung,Yu Ru Su,Richard B. Hayes,Emily White,Emily White,Pavel Vodicka,Graham Casey,Stephen B. Gruber,Robert E. Schoen,Andrew T. Chan,Andrew T. Chan,John D. Potter,Hermann Brenner,Gail P. Jarvik,Douglas A. Corley,Ulrike Peters,Ulrike Peters,Li Hsu,Li Hsu +102 more
TL;DR: Different approaches to generating predictive polygenic risk scores (PRS) from genome-wide association studies (GWASs) are derived and compared, and the developed PRS offers a way for risk-stratified CRC screening and other targeted interventions.
Journal ArticleDOI
Cumulative Burden of Colorectal Cancer Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer
Alexi N. Archambault,Yu Ru Su,Jihyoun Jeon,Minta Thomas,Yi Lin,David V. Conti,Aung Ko Win,Lori C. Sakoda,Lori C. Sakoda,Iris Lansdorp-Vogelaar,Elisabeth F.P. Peterse,Ann G. Zauber,David Duggan,Andreana N. Holowatyj,Jeroen R. Huyghe,Hermann Brenner,Michelle Cotterchio,Stéphane Bézieau,Stephanie L. Schmit,Christopher K. Edlund,Melissa C. Southey,Robert J. MacInnis,Robert J. MacInnis,Peter T. Campbell,Jenny Chang-Claude,Jenny Chang-Claude,Martha L. Slattery,Andrew T. Chan,Amit Joshi,Mingyang Song,Yin Cao,Yin Cao,Michael O. Woods,Emily White,Emily White,Stephanie J. Weinstein,Cornelia M. Ulrich,Michael Hoffmeister,Stephanie A. Bien,Tabitha A. Harrison,Jochen Hampe,Christopher I. Li,Clemens Schafmayer,Kenneth Offit,Kenneth Offit,Paul D.P. Pharoah,Victor Moreno,Annika Lindblom,Alicja Wolk,Anna H. Wu,Li Li,Marc J. Gunter,Andrea Gsur,Temitope O. Keku,Rachel Pearlman,D. Timothy Bishop,Sergi Castellví-Bel,Leticia Moreira,Pavel Vodicka,Pavel Vodicka,Pavel Vodicka,Ellen Kampman,Graham G. Giles,Demetrius Albanes,John A. Baron,Sonja I. Berndt,Stefanie Brezina,Stephan Buch,Daniel D. Buchanan,Daniel D. Buchanan,Antonia Trichopoulou,Gianluca Severi,María Dolores Chirlaque,María José Sánchez,Domenico Palli,Tilman Kühn,Neil Murphy,Amanda J. Cross,Andrea N. Burnett-Hartman,Stephen J. Chanock,Albert de la Chapelle,Douglas F. Easton,Faye Elliott,Dallas R. English,Edith J. M. Feskens,Liesel M. FitzGerald,Liesel M. FitzGerald,Phyllis J. Goodman,John L. Hopper,John L. Hopper,Thomas J. Hudson,David J. Hunter,David J. Hunter,Eric J. Jacobs,Corinne E. Joshu,Sébastien Küry,Sanford D. Markowitz,Roger L. Milne,Roger L. Milne,Elizabeth A. Platz,Gad Rennert,Hedy S. Rennert,Fredrick R. Schumacher,Robert S. Sandler,Daniela Seminara,Catherine M. Tangen,Stephen N. Thibodeau,Amanda E. Toland,Fränzel J.B. Van Duijnhoven,Kala Visvanathan,Ludmila Vodickova,Ludmila Vodickova,Ludmila Vodickova,John D. Potter,Satu Männistö,Korbinian Weigl,Korbinian Weigl,Jane C. Figueiredo,Jane C. Figueiredo,Vicente Martín,Susanna C. Larsson,Patrick S. Parfrey,Wen Yi Huang,Heinz-Josef Lenz,Jose E. Castelao,Manuela Gago-Dominguez,Victor Muñoz-Garzón,Christoph Mancao,Christopher A. Haiman,Lynne R. Wilkens,Erin M. Siegel,Elizabeth L. Barry,Ban Younghusband,Bethany Van Guelpen,Sophia Harlid,Anne Zeleniuch-Jacquotte,Peter S. Liang,Mengmeng Du,Graham Casey,Noralane M. Lindor,Loic Le Marchand,Steven Gallinger,Mark A. Jenkins,Polly A. Newcomb,Polly A. Newcomb,Stephen B. Gruber,Robert E. Schoen,Heather Hampel,Douglas A. Corley,Li Hsu,Li Hsu,Ulrike Peters,Ulrike Peters,Richard B. Hayes +153 more
TL;DR: In an analysis of associations with CRC per standard deviation of PRS, the cumulative burden of CRC-associated common genetic variants to associate with early-onset cancer, and to be more strongly associated with early toonset than late-ONSet cancer-particularly in the absence of CRC family history is found.
Journal ArticleDOI
Meta-analysis of 16 studies of the association of alcohol with colorectal cancer.
Sarah McNabb,Sarah McNabb,Tabitha A. Harrison,Demetrius Albanes,Sonja I. Berndt,Hermann Brenner,Bette J. Caan,Peter T. Campbell,Yin Cao,Jenny Chang-Claude,Andrew T. Chan,Andrew T. Chan,Zhengyi Chen,Dallas R. English,Dallas R. English,Graham G. Giles,Graham G. Giles,Edward Giovannucci,Edward Giovannucci,Phyllis J. Goodman,Richard B. Hayes,Michael Hoffmeister,Eric J. Jacobs,Amit Joshi,Susanna C. Larsson,Loic Le Marchand,Li Li,Yi Lin,Satu Männistö,Roger L. Milne,Roger L. Milne,Hongmei Nan,Christina C. Newton,Shuji Ogino,Patrick S. Parfrey,Paneen S. Petersen,John D. Potter,John D. Potter,John D. Potter,Robert E. Schoen,Martha L. Slattery,Yu Ru Su,Catherine M. Tangen,Thomas C. Tucker,Thomas C. Tucker,Stephanie J. Weinstein,Emily White,Emily White,Alicja Wolk,Alicja Wolk,Michael O. Woods,Amanda I. Phipps,Ulrike Peters,Ulrike Peters +53 more
TL;DR: In this article, a combined analysis of 16 studies of colorectal cancer was conducted to examine the shape of the alcohol-CRC association, investigate potential effect modifiers of the association, and examine differential effects of alcohol consumption by cancer anatomic site and stage.
Journal ArticleDOI
Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer.
Stephanie A. Bien,Stephanie A. Bien,Yu Ru Su,Yu Ru Su,David V. Conti,David V. Conti,Tabitha A. Harrison,Tabitha A. Harrison,Conghui Qu,Conghui Qu,Xingyi Guo,Xingyi Guo,Yingchang Lu,Yingchang Lu,Demetrius Albanes,Paul L. Auer,Paul L. Auer,Barbara L. Banbury,Barbara L. Banbury,Sonja I. Berndt,Stéphane Bezieau,Hermann Brenner,Daniel D. Buchanan,Bette J. Caan,Bette J. Caan,Peter T. Campbell,Peter T. Campbell,Christopher S. Carlson,Christopher S. Carlson,Andrew T. Chan,Andrew T. Chan,Andrew T. Chan,Jenny Chang-Claude,Jenny Chang-Claude,Jenny Chang-Claude,Sai Chen,Sai Chen,Charles M. Connolly,Charles M. Connolly,Douglas F. Easton,Douglas F. Easton,Edith J.M. Feskens,Edith J.M. Feskens,Steven Gallinger,Steven Gallinger,Graham G. Giles,Graham G. Giles,Graham G. Giles,Marc J. Gunter,Marc J. Gunter,Jochen Hampe,Jochen Hampe,Jeroen R. Huyghe,Jeroen R. Huyghe,Michael Hoffmeister,Michael Hoffmeister,Thomas J. Hudson,Thomas J. Hudson,Thomas J. Hudson,Eric J. Jacobs,Eric J. Jacobs,Mark A. Jenkins,Mark A. Jenkins,Ellen Kampman,Ellen Kampman,Hyun Min Kang,Hyun Min Kang,Tilman Kühn,Tilman Kühn,Sébastien Küry,Flavio Lejbkowicz,Flavio Lejbkowicz,Loic Le Marchand,Loic Le Marchand,RL Milne,RL Milne,RL Milne,Li Li,Li Li,Christopher I. Li,Christopher I. Li,Annika Lindblom,Annika Lindblom,Annika Lindblom,Noralane M. Lindor,Noralane M. Lindor,Vicente Martín,Vicente Martín,Caroline McNeil,Caroline McNeil,Marilena Melas,Marilena Melas,Victor Moreno,Polly A. Newcomb,Polly A. Newcomb,Kenneth Offit,Kenneth Offit,Paul D.P. Pharaoh,Paul D.P. Pharaoh,John D. Potter,John D. Potter,Chenxu Qu,Chenxu Qu,Elio Riboli,Elio Riboli,Gad Rennert,Gad Rennert,Núria Sala,Clemens Schafmayer,Peter C. Scacheri,Peter C. Scacheri,Stephanie L. Schmit,Gianluca Severi,Gianluca Severi,Martha L. Slattery,Martha L. Slattery,Joshua D. Smith,Joshua D. Smith,Antonia Trichopoulou,Antonia Trichopoulou,Rosario Tumino,Cornelia M. Ulrich,Cornelia M. Ulrich,Fränzel J. B. van Duijnhoven,Fränzel J. B. van Duijnhoven,Bethany Van Guelpen,Bethany Van Guelpen,Stephanie J. Weinstein,Emily White,Emily White,Alicja Wolk,Alicja Wolk,Alicja Wolk,Michael O. Woods,Michael O. Woods,Anna H. Wu,Anna H. Wu,Gonçalo R. Abecasis,Gonçalo R. Abecasis,Graham Casey,Graham Casey,Deborah A. Nickerson,Deborah A. Nickerson,Stephen B. Gruber,Stephen B. Gruber,Li Hsu,Li Hsu,Wei Zheng,Wei Zheng,Ulrike Peters,Ulrike Peters +150 more
TL;DR: PendiXcan as mentioned in this paper uses cis-regulatory variant predictors to impute expression and perform gene-level association tests in GWAS without directly measured transcriptomes, finding statistically significant associations using colon transcriptome models with TRIM4 and PYGL.