Sebelas Maret University

About: Sebelas Maret University is a education organization based out in Surakarta, Indonesia. It is known for research contribution in the topics: Population & Public health. The organization has 10901 authors who have published 10832 publications receiving 33057 citations. The organization is also known as: Universitas Negeri Surakarta & Universitas Sebelas Maret.

A greatly improved procedure for the synthesis of an antibiotic-drug candidate 2,4-diacetylphloroglucinol over silica sulphuric acid catalyst: multivariate optimisation and environmental assessment protocol comparison by metrics

Abstract: Efforts toward the development of a straightforward greener Gram-scale synthesis of the antibiotic compound 2,4-diacetylphloroglucinol (DAPG) have been developed. This beneficial procedure was accomplished through the Friedel–Crafts acylation of phloroglucinol over inexpensive heterogeneous silica sulphuric acid (SSA) catalyst via ultrasound-assisted (US) synthesis under solvent-free condition. The influences of various parameters such as temperature, catalyst loading, and reaction time on the reaction performance were analysed using a multivariate statistical modelling response surface methodology (RSM). A high yield of DAPG (95%) was achieved at 60 °C after 15–20 min reaction with the presence of 10% (w/w) SSA as the catalyst. Column chromatography-free and a Gram scale-up reaction also exhibited the practical applicability of this newly developed protocol. The SSA catalyst was recovered and recycled up to 10 consecutive runs with no appreciable loss of activity. A plausible mechanism for the Friedel–Crafts acylation of phloroglucinol is proposed. Moreover, an environmental assessment has been carried out over this present method and compared with several established literature using the EATOS software and the Andraos algorithm to assess the consumption of the substrates, solvents, catalysts, and the production of coupled products or by-products. In addition, their energy consumptions were also determined. The data collected showed that the present method is the most promising one, characterised by the highest environmental impact profile against all the other reported methods. The physicochemical properties of the synthesised DAPG were assessed and exhibited reasonable oral bioavailability drug property as determined by Lipinski's rules.

The academic motivation of papuan students in Sebelas Maret University, Indonesia

Abstract: The primary objective of learning engaged in higher education is to build graduate students who have great competence. This study aims to analyze the academic motivation of Papuan students at Sebel...

Development of Three-Tier Diagnostics Instruments on Students Misconception Test in Fluid Concept

Abstract: The purpose of this research was to know the validity and reliability of instrument three-tier diagnosis to identify the students’ misconception in fluid concept. The stages of development research that used in this research were (1) The first research and collecting information, (2) planning and designing of development (3) validity and product evaluation. The instrument of the test was tested on 98 students of 3 schools. The instrument has been developed and categorized effectively because it has a valid category with the Aiken validity index value> from table V (0.75) and the reliability of the instrument has a value of 0.96 with a high category. The instrument of three-tier test that developed was able to identify the students' comprehension in students' concept and students' misconception. There are 27,58% students comprehend the concept, 45,29% students did not comprehend the concept, 24,74% students showed that misconception and 2,36% students experienced errors