Institution
University of Bergen
Education•Bergen, Hordaland, Norway•
About: University of Bergen is a education organization based out in Bergen, Hordaland, Norway. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 17106 authors who have published 52492 publications receiving 2009844 citations. The organization is also known as: Universitetet i Bergen & Universitas Bergensis.
Papers published on a yearly basis
Papers
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TL;DR: Overlapping metamorphic and magmatic dates from the pillow lavas suggest that microbial life colonized these subaqueous volcanic rocks soon after their eruption almost 3.5 billion years ago.
Abstract: Pillow lava rims from the Mesoarchean Barberton Greenstone Belt in South Africa contain micrometer-scale mineralized tubes that provide evidence of submarine microbial activity during the early history of Earth. The tubes formed during microbial etching of glass along fractures, as seen in pillow lavas from recent oceanic crust. The margins of the tubes contain organic carbon, and many of the pillow rims exhibit isotopically light bulk-rock carbonate δ 13 C values, supporting their biogenic origin. Overlapping metamorphic and magmatic dates from the pillow lavas suggest that microbial life colonized these subaqueous volcanic rocks soon after their eruption almost 3.5 billion years ago.
310 citations
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TL;DR: It is shown that endostatin-transfected cells encapsulated in alginate maintainendostatin secretion for at least four months after intracerebral implantation in rats, and may provide the basis for new therapeutic approaches toward brain tumors.
Abstract: We describe a technique for the treatment of malignant brain tumors based on local delivery of the anti-angiogenic protein endostatin from genetically engineered cells encapsulated in ultrapure sodium alginate. Alginate consists of L-guluronic and D-mannuronic acid, which in the presence of divalent cations forms an extended gel network, in which cells reside and remain immunoisolated, when implanted into the rat brain. Here, we show that endostatin-transfected cells encapsulated in alginate maintain endostatin secretion for at least four months after intracerebral implantation in rats. During the implantation period 70% of the encapsulated cells remained viable, as opposed to 85% in in vitro-cultured capsules. Rats that received transplants of BT4C glioma cells, together with endostatin-producing capsules (0.2 μg/ml per capsule), survived 84% longer than the controls. The endostatin released from the capsules led to an induction of apoptosis, hypoxia, and large necrotic avascular areas within 77% of the treated tumors, whereas all the controls were negative. The encapsulation technique may be used for many different cell lines engineered to potentially interfere with the complex microenvironment in which tumor and normal cells reside. The present work may thus provide the basis for new therapeutic approaches toward brain tumors.
310 citations
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Brookhaven National Laboratory1, CERN2, Tel Aviv University3, Thomas Jefferson National Accelerator Facility4, Ruhr University Bochum5, University of Basel6, Joseph Fourier University7, Lawrence Berkeley National Laboratory8, Petersburg Nuclear Physics Institute9, University of Bergen10, Goethe University Frankfurt11, Creighton University12, Pennsylvania State University13, University of California, Davis14, Lawrence Livermore National Laboratory15, Rice University16
TL;DR: In this article, the physics of large impact parameter interactions at the LHC were discussed, and the dominant processes in UPCs are photon-nucleon (nucleus) interactions.
310 citations
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TL;DR: Findings are consistent with the concept of autism as a spectrum, and large differences across informants suggested the need to gather information both from families and from schools when screening for autism spectrum disorders.
Abstract: Background: The prevalence of autism is reported to be on the rise worldwide. Change of diagnostic criteria and a broadening of the concept of autism have been mentioned as contributing factors. Further studies of general populations are needed. The present study assessed the distribution of autistic features in a total population of children 7–9 years of age, and explored the impact of age, gender, informant, and participation bias on symptom report.
Methods: Teacher and parent forms of the Autism Spectrum Screening Questionnaire (ASSQ) were used in the ‘Bergen Child Study’, a total population study of 9430 children aged 7–9 years. Completed teacher forms were returned for 97% and parent forms for 71% of the children. High-scorers were defined according to the ASSQ validation study by Ehlers, Gillberg, and Wing (1999).
Results: The distribution of ASSQ scores was found to be almost continuous. Of the children with both a teacher and a parent form, 2.1% were defined as high-scorers. Children without parent informed consent (i.e., anonymous children) obtained significantly higher teacher scores than those who had questionnaires completed by both parent and teacher. Adjusting prevalence for the anonymous children, the prevalence of high-scorers was 2.7% of the total population. Age did not affect symptom scores. Boys scored higher and parents reported more symptoms, particularly in girls. Agreement between informants was low to moderate.
Conclusions: Autism symptoms are not uncommon in the general population of children. Our findings are consistent with the concept of autism as a spectrum. Non-responders had a higher load of autism symptoms than identified children, indicating that reports on the prevalence of autism in a responder group underestimate true prevalence. Large differences across informants suggested the need to gather information both from families and from schools when screening for autism spectrum disorders.
309 citations
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TL;DR: Experimental findings suggest, however, that connective tissue repair to the root surface following reconstructive periodontal surgery is a function of the establishment and maintenance of a root surface-adhering fibrin clot.
Abstract: Wound healing in an incisional wound is a highly predictable process which has been studied extensively hour-by-hour and day-by-day. Healing in a periodontal defect following gingival flap surgery is, conceptually, a more complex process as one wound margin consists of calcified tissue, including the avascular and rigid root surface. Another complicating factor in this wound healing is the transgingival position of the tooth. Experimental studies, however, have indicated that healing at a dento-gingival interface under optimal conditions occurs at the same rate as in a skin wound. Generally, periodontal healing is characterized by maturation of gingival connective tissue, limited regeneration of alveolar bone and cementum, and the formation of a long junctional epithelium. Such observations have nurtured the hypothesis that the epithelium of the surgical flap needs to be prevented from early access to the root surface during the healing period to achieve connective tissue repair of the root surface-gingival flap interface. Recent experimental findings suggest, however, that connective tissue repair to the root surface following reconstructive periodontal surgery is a function of the establishment and maintenance of a root surface-adhering fibrin clot. Since fibrin adherence to the wound margins is a natural event, it is additionally suggested that apical migration of the gingival epithelium in periodontal surgical wounds may only follow interruption of the adherence of the fibrin clot to the root surface.
309 citations
Authors
Showing all 17370 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stephen V. Faraone | 188 | 1427 | 140298 |
Patrick O. Brown | 183 | 755 | 200985 |
Anil K. Jain | 183 | 1016 | 192151 |
Marc Weber | 167 | 2716 | 153502 |
Johan Auwerx | 158 | 653 | 95779 |
Leif Groop | 158 | 919 | 136056 |
Charles M. Perou | 156 | 573 | 202951 |
Bart Staels | 152 | 824 | 86638 |
Zhenwei Yang | 150 | 956 | 109344 |
G. Eigen | 148 | 2188 | 117450 |
Thomas Lohse | 148 | 1237 | 101631 |
Marco Costa | 146 | 1458 | 105096 |
Timothy P. Hughes | 145 | 831 | 91357 |
Hermann Kolanoski | 145 | 1279 | 96152 |
Kjell Fuxe | 142 | 1479 | 89846 |