Institution
University of Bergen
Education•Bergen, Hordaland, Norway•
About: University of Bergen is a education organization based out in Bergen, Hordaland, Norway. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 17106 authors who have published 52492 publications receiving 2009844 citations. The organization is also known as: Universitetet i Bergen & Universitas Bergensis.
Papers published on a yearly basis
Papers
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TL;DR: The characterization of TNT-like bridges from several cell types revealed variations in the cytoskeletal composition as well as in the modality by which they interconnect cells, suggesting that different subclasses may exist.
292 citations
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Harvard University1, University of Groningen2, Laval University3, University of Leicester4, University of Nottingham5, National Institutes of Health6, University of North Carolina at Chapel Hill7, St George's, University of London8, Johns Hopkins University9, Anschutz Medical Campus10, University of Colorado Denver11, University of Washington12, Group Health Cooperative13, Utrecht University14, GlaxoSmithKline15, University of Nebraska Medical Center16, AstraZeneca17, University of Manchester18, University of British Columbia19, Boston University20, Kangwon National University21, University of Ulsan22, Erasmus University Rotterdam23, Lovelace Respiratory Research Institute24, University of Virginia25, Columbia University26, University of Bergen27, Ghent University28, Wake Forest University29, University of California, San Francisco30, University College London31, Seoul National University32, University of Edinburgh33, Glenfield Hospital34
TL;DR: In the combined meta-analysis, 22 loci associated at genome-wide significance are identified, including 13 new associations with COPD, including 12 associated with lung function in general population samples, while 4 are new.
Abstract: Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10(-6)) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identified 22 loci associated at genome-wide significance, including 13 new associations with COPD. Nine of these 13 loci have been associated with lung function in general population samples, while 4 (EEFSEC, DSP, MTCL1, and SFTPD) are new. We noted two loci shared with pulmonary fibrosis (FAM13A and DSP) but that had opposite risk alleles for COPD. None of our loci overlapped with genome-wide associations for asthma, although one locus has been implicated in joint susceptibility to asthma and obesity. We also identified genetic correlation between COPD and asthma. Our findings highlight new loci associated with COPD, demonstrate the importance of specific loci associated with lung function to COPD, and identify potential regions of genetic overlap between COPD and other respiratory diseases.
292 citations
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TL;DR: Patients with HFrEF who were treated with less than 50% of recommended dose of ACE-inhibitors/ARBs and beta-blockers seemed to have a greater risk of death and/or heart failure hospitalization compared with patients reaching ≥100%.
Abstract: Introduction:
Despite clear guidelines recommendations, most patients with heart failure and reduced ejection–fraction (HFrEF) do not attain guideline-recommended target doses. We aimed to investigate characteristics and for treatment-indication-bias corrected clinical outcome of patients with HFrEF that did not reach recommended treatment doses of ACE-inhibitors/Angiotensin receptor blockers (ARBs) and/or beta-blockers.
Methods and results:
BIOSTAT-CHF was specifically designed to study uptitration of ACE-inhibitors/ARBs and/or beta-blockers in 2516 heart failure patients from 69 centres in 11 European countries who were selected if they were suboptimally treated while initiation or uptitration was anticipated and encouraged. Patients who died during the uptitration period (n = 151) and patients with a LVEF > 40% (n = 242) were excluded. Median follow up was 21 months. We studied 2100 HFrEF patients (76% male; mean age 68 ±12), of which 22% achieved the recommended treatment dose for ACE-inhibitor/ARB and 12% of beta-blocker. There were marked differences between European countries. Reaching <50% of the recommended ACE-inhibitor/ARB and beta-blocker dose was associated with an increased risk of death and/or heart failure hospitalization. Patients reaching 50–99% of the recommended ACE-inhibitor/ARB and/or beta-blocker dose had comparable risk of death and/or heart failure hospitalization to those reaching ≥100%. Patients not reaching recommended dose because of symptoms, side effects and non-cardiac organ dysfunction had the highest mortality rate (for ACE-inhibitor/ARB: HR 1.72; 95% CI 1.43–2.01; for beta-blocker: HR 1.70; 95% CI 1.36–2.05).
Conclusion:
Patients with HFrEF who were treated with less than 50% of recommended dose of ACE-inhibitors/ARBs and beta-blockers seemed to have a greater risk of death and/or heart failure hospitalization compared with patients reaching ≥100%.
292 citations
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TL;DR: Symptomatic prolapse is less common among African-American women and more common among women with a prior vaginal delivery, poor health status, constipation, or irritable bowel syndrome and nearly one half of women with symptomatic Prolapse are substantially bothered by their symptoms.
292 citations
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TL;DR: In this paper, the authors examine three bodies of theory: individualization, the lifecourse, and concepts of time with respect to how young people talk about the future and the bearing of young people's situations and time perspectives upon the way they envisage the transition to adulthood.
Abstract: The article examines three bodies of theory: individualization, the lifecourse, and concepts of time. It interrogates these theories with respect to the following questions: how young people speak about the future; and the bearing of young people's situations and time perspectives upon the way they envisage the transition to adulthood. It draws upon empirical research from a five-country European study, in particular material from focus group discussions conducted with young people in two west-European countries, Britain and Norway. It analyses variations in young peoples' ways of thinking about their future lives, and proposes, as a basis for further research, three ideal typical models.
292 citations
Authors
Showing all 17370 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stephen V. Faraone | 188 | 1427 | 140298 |
Patrick O. Brown | 183 | 755 | 200985 |
Anil K. Jain | 183 | 1016 | 192151 |
Marc Weber | 167 | 2716 | 153502 |
Johan Auwerx | 158 | 653 | 95779 |
Leif Groop | 158 | 919 | 136056 |
Charles M. Perou | 156 | 573 | 202951 |
Bart Staels | 152 | 824 | 86638 |
Zhenwei Yang | 150 | 956 | 109344 |
G. Eigen | 148 | 2188 | 117450 |
Thomas Lohse | 148 | 1237 | 101631 |
Marco Costa | 146 | 1458 | 105096 |
Timothy P. Hughes | 145 | 831 | 91357 |
Hermann Kolanoski | 145 | 1279 | 96152 |
Kjell Fuxe | 142 | 1479 | 89846 |