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Institution

University of Colorado Boulder

EducationBoulder, Colorado, United States
About: University of Colorado Boulder is a education organization based out in Boulder, Colorado, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 48794 authors who have published 115151 publications receiving 5387328 citations. The organization is also known as: CU Boulder & UCB.


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Journal ArticleDOI
TL;DR: A new view is described which argues that cytokines signal brain in quite a different manner, by stimulating afferent terminals of peripheral nerves at local sites of synthesis and release.

605 citations

Journal ArticleDOI
TL;DR: In this paper, the same principles of mass and momentum conservation, combined with a continuity argument, lead to the correct boundary conditions for the pressure Poisson equation: viz., a Neumann condition that is derived simply by applying the normal component of the momentum equation at the boundary.
Abstract: The pressure is a somewhat mysterious quantity in incompressible flows. It is not a thermodynamic variable as there is no ‘equation of state’ for an incompressible fluid. It is in one sense a mathematical artefact—a Lagrange multiplier that constrains the velocity field to remain divergence-free; i.e., incompressible—yet its gradient is a relevant physical quantity: a force per unit volume. It propagates at infinite speed in order to keep the flow always and everywhere incompressible; i.e., it is always in equilibrium with a time-varying divergence-free velocity field. It is also often difficult and/or expensive to compute. While the pressure is perfectly well-defined (at least up to an arbitrary additive constant) by the governing equations describing the conservation of mass and momentum, it is (ironically) less so when more directly expressed in terms of a Poisson equation that is both derivable from the original conservation equations and used (or misused) to replace the mass conservation equation. This is because in this latter form it is also necessary to address directly the subject of pressure boundary conditions, whose proper specification is crucial (in many ways) and forms the basis of this work. Herein we show that the same principles of mass and momentum conservation, combined with a continuity argument, lead to the correct boundary conditions for the pressure Poisson equation: viz., a Neumann condition that is derived simply by applying the normal component of the momentum equation at the boundary. It usually follows, but is not so crucial, that the tangential momentum equation is also satisfied at the boundary.

604 citations

Journal ArticleDOI
TL;DR: This paper examined the validity of the assumption that reading comprehension tests are all measuring the same thing by comparing some of the most popular reading comprehension measures used in research and clinical practice in the United States: the Gray Oral Reading Test (GORT), the two assessments (retellings and comprehension questions) from the Qualitative Reading Inventory (QRI), the Woodcock-Johnson Passage Comprehension subtest (WJPC), and the reading comprehension test from the Peabody Individual Achievement Test (PIAT).
Abstract: Comprehension tests are often used interchangeably, suggesting an implicit assumption that they are all measuring the same thing. We examine the validity of this assumption by comparing some of the most popular reading comprehension measures used in research and clinical practice in the United States: the Gray Oral Reading Test (GORT), the two assessments (retellings and comprehension questions) from the Qualitative Reading Inventory (QRI), the Woodcock–Johnson Passage Comprehension subtest (WJPC), and the Reading Comprehension test from the Peabody Individual Achievement Test (PIAT). Modest intercorrelations among the tests suggested that they were measuring different skills. Regression analyses showed that decoding, not listening comprehension, accounts for most of the variance in both the PIAT and the WJPC; the reverse holds for the GORT and both QRI measures. Large developmental differences in what the tests measure were found for the PIAT and the WJPC, but not the other tests, both when development w...

602 citations

Journal ArticleDOI
TL;DR: The selection of preferred step width in human walking is studied by measuring mechanical and metabolic costs as a function of experimentally manipulated step width and humans appear to prefer a step width that minimizes metabolic cost.
Abstract: We studied the selection of preferred step width in human walking by measuring mechanical and metabolic costs as a function of experimentally manipulated step width (0.00^0.45L, as a fraction of leg length L). We estimated mechanical costs from individual limb external mechanical work and metabolic costs using open circuit respirometry. The mechanical and metabolic costs both increased substantially (54 and 45%, respectively) for widths greater than the preferred value (0.15^0.45L) and with step width squared (R 2 ˆ 0.91 and 0.83, respectively). As predicted by a three-dimensional model of walking mechanics, the increases in these costs appear to be a result of the mechanical work required for redirecting the centre of mass velocity during the transition between single stance phases (step-to-step transition costs). The metabolic cost for steps narrower than preferred (0.10^0.00L) increased by 8%, which was probably as a result of the added cost of moving the swing leg laterally in order to avoid the stance leg (lateral limb swing cost). Trade-ois between the step-to-step transition and lateral limb swing costs resulted in a minimum metabolic cost at a step width of 0.12L, which is not signi¢cantly diierent from foot width (0.11L) or the preferred step width (0.13L). Humans appear to prefer a step width that minimizes metabolic cost.

601 citations

Journal ArticleDOI
TL;DR: Two recently proposed randomized algorithms for the construction of low-rank approximations to matrices are described and shown to be considerably more efficient and reliable than the classical (deterministic) ones; they also parallelize naturally.
Abstract: We describe two recently proposed randomized algorithms for the construction of low-rank approximations to matrices, and demonstrate their application (inter alia) to the evaluation of the singular value decompositions of numerically low-rank matrices. Being probabilistic, the schemes described here have a finite probability of failure; in most cases, this probability is rather negligible (10−17 is a typical value). In many situations, the new procedures are considerably more efficient and reliable than the classical (deterministic) ones; they also parallelize naturally. We present several numerical examples to illustrate the performance of the schemes.

600 citations


Authors

Showing all 49233 results

NameH-indexPapersCitations
Yi Chen2174342293080
Robert J. Lefkowitz214860147995
Rob Knight2011061253207
Charles A. Dinarello1901058139668
Jie Zhang1784857221720
David Haussler172488224960
Bradley Cox1692150156200
Gang Chen1673372149819
Rodney S. Ruoff164666194902
Menachem Elimelech15754795285
Jay Hauser1552145132683
Robert E. W. Hancock15277588481
Robert Plomin151110488588
Thomas E. Starzl150162591704
Rajesh Kumar1494439140830
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023164
2022780
20216,287
20206,493
20196,063
20185,522