Institution
University of Connecticut
Education•Storrs, Connecticut, United States•
About: University of Connecticut is a education organization based out in Storrs, Connecticut, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 35297 authors who have published 81224 publications receiving 2952682 citations. The organization is also known as: UConn & Storrs Agricultural School.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this article, the authors summarize the current development of theoretical models describing properties of polyelectrolyte solutions and adsorption of charged polymers at surfaces and interfaces, and discuss conformational properties and the phenomenon of counterion condensation.
1,335 citations
••
University of California, Los Angeles1, Medical University of South Carolina2, Rutgers University3, University of Illinois at Chicago4, Boston University5, Johns Hopkins University6, Georgetown University7, University of Texas Health Science Center at Houston8, Wayne State University9, University of California, San Francisco10, University of Alabama11, University of Connecticut12
TL;DR: One year of oral cyclophosphamide in patients with symptomatic scleroderma-related interstitial lung disease had a significant but modest beneficial effect on lung function, dyspnea, thickening of the skin, and the health-related quality of life.
Abstract: BACKGROUND We conducted a double-blind, randomized, placebo-controlled trial to determine the effects of oral cyclophosphamide on lung function and health-related symptoms in patients with evidence of active alveolitis and scleroderma-related interstitial lung disease. METHODS At 13 clinical centers throughout the United States, we enrolled 158 patients with scleroderma, restrictive lung physiology, dyspnea, and evidence of inflammatory interstitial lung disease on examination of bronchoalveolar-lavage fluid, thoracic highresolution computed tomography, or both. Patients received oral cyclophosphamide (≤2 mg per kilogram of body weight per day) or matching placebo for one year and were followed for an additional year. Pulmonary function was assessed every three months during the first year, and the primary end point was the forced vital capacity (FVC, expressed as a percentage of the predicted value) at 12 months, after adjustment for the baseline FVC. RESULTS Of 158 patients, 145 completed at least six months of treatment and were included in the analysis. The mean absolute difference in adjusted 12-month FVC percent predicted between the cyclophosphamide and placebo groups was 2.53 percent (95 percent confidence interval, 0.28 to 4.79 percent), favoring cyclophosphamide (P<0.03). There were also treatment-related differences in physiological and symptom outcomes, and the difference in FVC was maintained at 24 months. There was a greater frequency of adverse events in the cyclophosphamide group, but the difference between the two groups in the number of serious adverse events was not significant. CONCLUSIONS One year of oral cyclophosphamide in patients with symptomatic sclerodermarelated interstitial lung disease had a significant but modest beneficial effect on lung function, dyspnea, thickening of the skin, and the health-related quality of life. The effects on lung function were maintained through the 24 months of the study.
1,330 citations
••
TL;DR: Suggestions for enhancing the capacity for generalization in terms of all three models are offered, which cover such issues as planned replication, sampling strategies, systematic reviews, reflexivity and higher-order conceptualization, thick description, mixed methods research, and the RE-AIM framework within pragmatic trials.
1,320 citations
••
20 Aug 2017TL;DR: “Ouroboros” is presented, the first blockchain protocol based on proof of stake with rigorous security guarantees and it is proved that, given this mechanism, honest behavior is an approximate Nash equilibrium, thus neutralizing attacks such as selfish mining.
Abstract: We present “Ouroboros”, the first blockchain protocol based on proof of stake with rigorous security guarantees. We establish security properties for the protocol comparable to those achieved by the bitcoin blockchain protocol. As the protocol provides a “proof of stake” blockchain discipline, it offers qualitative efficiency advantages over blockchains based on proof of physical resources (e.g., proof of work). We also present a novel reward mechanism for incentivizing Proof of Stake protocols and we prove that, given this mechanism, honest behavior is an approximate Nash equilibrium, thus neutralizing attacks such as selfish mining.
1,314 citations
••
TL;DR: A technique for manipulating quantum information stored in collective states of mesoscopic ensembles by optical excitation into states with strong dipole-dipole interactions that can be employed for controlled generation of collective atomic spin states as well as nonclassical photonic states and for scalable quantum logic gates is described.
Abstract: We describe a technique for manipulating quantum information stored in collective states of mesoscopic ensembles. Quantum processing is accomplished by optical excitation into states with strong dipole-dipole interactions. The resulting "dipole blockade" can be used to inhibit transitions into all but singly excited collective states. This can be employed for a controlled generation of collective atomic spin states as well as nonclassical photonic states and for scalable quantum logic gates. An example involving a cold Rydberg gas is analyzed.
1,310 citations
Authors
Showing all 35666 results
Name | H-index | Papers | Citations |
---|---|---|---|
Zhong Lin Wang | 245 | 2529 | 259003 |
Richard A. Flavell | 231 | 1328 | 205119 |
Ralph Weissleder | 184 | 1160 | 142508 |
Eric J. Nestler | 178 | 748 | 116947 |
David L. Kaplan | 177 | 1944 | 146082 |
Masayuki Yamamoto | 171 | 1576 | 123028 |
Mark Gerstein | 168 | 751 | 149578 |
Marc A. Pfeffer | 166 | 765 | 133043 |
Carl W. Cotman | 165 | 809 | 105323 |
Murray F. Brennan | 161 | 925 | 97087 |
Alfred L. Goldberg | 156 | 474 | 88296 |
Xiang Zhang | 154 | 1733 | 117576 |
Hakon Hakonarson | 152 | 968 | 101604 |
Christopher P. Cannon | 151 | 1118 | 108906 |
James M. Wilson | 150 | 1010 | 78686 |