Institution
University of Extremadura
Education•Badajoz, Spain•
About: University of Extremadura is a education organization based out in Badajoz, Spain. It is known for research contribution in the topics: Population & Hyperspectral imaging. The organization has 7856 authors who have published 18299 publications receiving 396126 citations. The organization is also known as: Universidad de Extremadura.
Papers published on a yearly basis
Papers
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TL;DR: Two amino‐acid polymorphisms of cytochrome P4502C9, an enzyme involved in the metabolism of several nonsteroidal anti‐inflammatory drugs (NSAIDs), were studied in 94 individuals with acute bleeding after NSAIDs use and 124 individuals receiving NSAIDs with no adverse effects, suggesting that the inherited impairment of CYP2C 9 activity increases the risk for severe adverse drug reactions afterNSAIDs use.
Abstract: Impaired drug metabolism is a major cause of adverse drug reactions, and it is often caused by mutations at genes coding for drug-metabolising enzymes. Two amino-acid polymorphisms of cytochrome P4502C9 (CYP2C9), an enzyme involved in the metabolism of several nonsteroidal anti-inflammatory drugs (NSAIDs), were studied in 94 individuals with acute bleeding after NSAIDs use and 124 individuals receiving NSAIDs with no adverse effects. The frequency of CYP2C9 variant alleles was increased in overall bleeding patients, with a significant trend to higher risk with increasing number of variant alleles (P=0.02). The odds ratio for bleeding patients receiving CYP2C9 substrates (n=33) was 2.5 for heterozygous and 3.7 for homozygous carriers of mutations (P<0.015), suggesting that the inherited impairment of CYP2C9 activity increases the risk for severe adverse drug reactions after NSAIDs use.
118 citations
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Tel Aviv University1, VU University Medical Center2, National and Kapodistrian University of Athens3, University of Patras4, University of Cologne5, University of California, Los Angeles6, University of Extremadura7, Democritus University of Thrace8, University of Melbourne9, French Institute of Health and Medical Research10, University of Colorado Hospital11, Medical College of Wisconsin12
TL;DR: The participants, members of the ISP Pharmacogenomics Education Forum, proposed a document of ‘Background Statement’ and ‘Recommendations and Call for Action’ addressed to Deans of Education at Medical, Pharmaceutical, and Health Schools globally, and the result is presented here.
Abstract: Pharmacogenomics would be instrumental for the realization of personalized medicine in coming decades. Efforts are evident to clarify the potential bioethical, societal, and legal implications of key pharmacogenomics-based technologies projected to be soon introduced into the core practice of medicine. In sharp contrast, a lack of sufficient attention to educational aspects of pharmacogenomics, both for professionals and for society at large, is evident. In order to contribute to this discussion, a 'Pharmacogenomics Education Forum' was held on October 2, 2004 during the 3rd Annual Meeting of the International Society of Pharmacogenomics (ISP) at Santorini, Greece. The participants, members of the ISP Pharmacogenomics Education Forum, after deliberate discussions, proposed a document of 'Background Statement' and 'Recommendations and Call for Action' addressed to Deans of Education at Medical, Pharmaceutical, and Health Schools globally. This document has been considered by the education committee of the International Society of Pharmacogenomics and the result is presented here. We hope that this call would be listened to, and soon followed by beneficial action, ultimately leading to enhanced implementation of personalized medicine into core medical education and practice.
118 citations
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TL;DR: Highly social bird species such as the house martin, which are subject to intense selection by parasites, have a limited scope for immediate microevolutionary response to selection because of low heritabilities, but also alimited scope for long-term response to Selection because evolvability as indicated by small additive genetic coefficients of variation is weak.
Abstract: Directional selection for parasite resistance is often intense in highly social host species. Using a partial cross-fostering experiment we studied environmental and genetic variation in immune response and morphology in a highly colonial bird species, the house martin (Delichon urbica). We manipulated intensity of infestation of house martin nests by the haematophagous parasitic house martin bug Oeciacus hirundinis either by spraying nests with a weak pesticide or by inoculating them with 50 bugs. Parasitism significantly affected tarsus length, T cell response, immunoglobulin and leucocyte concentrations. We found evidence of strong environmental effects on nestling body mass, body condition, wing length and tarsus length, and evidence of significant additive genetic variance for wing length and haematocrit. We found significant environmental variance, but no significant additive genetic variance in immune response parameters such as T cell response to the antigenic phytohemagglutinin, immunoglobulins, and relative and absolute numbers of leucocytes. Environmental variances were generally greater than additive genetic variances, and the low heritabilities of phenotypic traits were mainly a consequence of large environmental variances and small additive genetic variances. Hence, highly social bird species such as the house martin, which are subject to intense selection by parasites, have a limited scope for immediate microevolutionary response to selection because of low heritabilities, but also a limited scope for long-term response to selection because evolvability as indicated by small additive genetic coefficients of variation is weak.
118 citations
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26 Sep 2005TL;DR: This process evaluates the suitability of several existing Web, multimedia and hypermedia methodologies to demonstrate that each one accomplishes only few RIA features, so new methodologies or extensions of the actual methodologies become necessary.
Abstract: Several methodologies and tools have been proposed for Web applications design and development. However, traditional Web applications are still inadequate to support the interaction and presentation functionalities demanded by the users. Recently, rich Internet applications (RIAs) have been proposed as an answer to these problems providing new levels of interactivity and presentation. The use of RIAs is growing exponentially; nevertheless there is a lack of full development methodologies in this sense. This document outlines the main features, which should be modeled in RIAs and proposes an evaluation process in order to obtain the suitability of a methodology to accomplish this goal. We also use this process to evaluate the suitability of several existing Web, multimedia and hypermedia methodologies to demonstrate that each one accomplishes only few RIA features, so new methodologies or extensions of the actual methodologies become necessary.
118 citations
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TL;DR: The Post-hospitalisation COVID-19 study (PHOSP-COVID) as mentioned in this paper is a prospective, longitudinal cohort study recruiting adults (aged ≥18 years) discharged from hospital with COVID19 across the UK.
118 citations
Authors
Showing all 8001 results
Name | H-index | Papers | Citations |
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Russel J. Reiter | 169 | 1646 | 121010 |
Donald G. Truhlar | 165 | 1518 | 157965 |
Manel Esteller | 146 | 713 | 96429 |
David J. Williams | 107 | 2060 | 62440 |
Keijo Häkkinen | 99 | 421 | 31355 |
Robert H. Anderson | 97 | 1237 | 41250 |
Leif Bertilsson | 87 | 321 | 23933 |
Mario F. Fraga | 84 | 267 | 32957 |
YangQuan Chen | 84 | 1048 | 36543 |
Antonio Plaza | 79 | 631 | 29775 |
Robert D. Gibbons | 75 | 349 | 26330 |
Jocelyn Chanussot | 73 | 614 | 27949 |
Naresh Magan | 72 | 400 | 17511 |
Luis Puelles | 71 | 269 | 19858 |
Jun Li | 70 | 799 | 19510 |