Institution
University of Florence
Education•Florence, Toscana, Italy•
About: University of Florence is a education organization based out in Florence, Toscana, Italy. It is known for research contribution in the topics: Population & Carbonic anhydrase. The organization has 27292 authors who have published 79599 publications receiving 2341684 citations. The organization is also known as: Università degli studi di Firenze & Universita degli studi di Firenze.
Papers published on a yearly basis
Papers
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TL;DR: The state of the art of preclinical studies on anticancer gold compounds, carried out either in vitro or in vivo, are defined and the overall perspectives on the development of gold compounds as effective anticancer drugs with an innovative mechanism of action are critically discussed.
Abstract: Gold compounds are a class of metallodrugs with great potential for cancer treatment. During the last two decades, a large variety of gold(I) and gold(III) compounds are reported to possess relevant antiproliferative properties in vitro against selected human tumor cell lines, qualifying themselves as excellent candidates for further pharmacological evaluation. The unique chemical properties of the gold center confer very interesting and innovative pharmacological profiles to gold-based metallodrugs. The primary goal of this review is to define the state of the art of preclinical studies on anticancer gold compounds, carried out either in vitro or in vivo. The available investigations of anticancer gold compounds are analyzed in detail, and particular attention is devoted to underlying molecular mechanisms. Notably, a few biophysical studies reveal that the interactions of cytotoxic gold compounds with DNA are generally far weaker than those of platinum drugs, implying the occurrence of a substantially different mode of action. A variety of alternative mechanisms were thus proposed, of which those involving either direct mitochondrial damage or proteasome inhibition or modulation of specific kinases are now highly credited. The overall perspectives on the development of gold compounds as effective anticancer drugs with an innovative mechanism of action are critically discussed on the basis of the available experimental evidence.
389 citations
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TL;DR: Sexual health declined while concomitant morbidities increased in European men as a function of age, emphasizing the need to develop more effective strategies to promote healthy aging for men in transitional countries.
389 citations
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TL;DR: A disordered system of ultracold strongly interacting 87Rb bosons is experimentally realized and a broadening of the Mott-insulator resonances and the transition to a state with vanishing long-range phase coherence and a flat density of excitations are observed, which suggest the formation of a Bose-glass phase.
Abstract: We use a bichromatic optical lattice to experimentally realize a disordered system of ultracold strongly interacting $^{87}\mathrm{Rb}$ bosons. In the absence of disorder, the atoms are pinned by repulsive interactions in the sites of an ideal optical crystal, forming one-dimensional Mott-insulator states. We measure the excitation spectrum of the system as a function of disorder strength and characterize its phase-coherence properties with a time-of-flight technique. Increasing disorder, we observe a broadening of the Mott-insulator resonances and the transition to a state with vanishing long-range phase coherence and a flat density of excitations, which suggest the formation of a Bose-glass phase.
388 citations
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TL;DR: In this article, the authors proposed to jointly consider absolute daily returns, daily high-low range and daily realized volatility to develop a forecasting model based on their conditional dynamics, which is consistent and asymptotically normal under a wide range of specifications for the error density function.
388 citations
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TL;DR: TH1 and TH2 cells play different roles not only in protection against exogenous offending agents, but also in immunopathology, and are involved in contact dermatitis, organ-specific autoimmunity and allograft rejection.
Abstract: A large body of evidence has accumulated suggesting the existence of human TH1 and TH2 subsets, reminiscent of those described for mouse T cells. Human TH1 cells develop in response to intracellular b
388 citations
Authors
Showing all 27699 results
Name | H-index | Papers | Citations |
---|---|---|---|
Charles A. Dinarello | 190 | 1058 | 139668 |
D. M. Strom | 176 | 3167 | 194314 |
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Christopher M. Dobson | 150 | 1008 | 105475 |
Dirk Inzé | 149 | 647 | 74468 |
Thomas Hebbeker | 148 | 1984 | 114004 |
Marco Zanetti | 145 | 1439 | 104610 |
Richard B. Devereux | 144 | 962 | 116403 |
Gunther Roland | 141 | 1471 | 100681 |
Markus Klute | 139 | 1447 | 104196 |
Tariq Aziz | 138 | 1646 | 96586 |
Guido Tonelli | 138 | 1458 | 97248 |
Giorgio Trinchieri | 138 | 433 | 78028 |
Christof Roland | 137 | 1308 | 96632 |
Christoph Paus | 137 | 1585 | 100801 |