University of Florence

About: University of Florence is a education organization based out in Florence, Toscana, Italy. It is known for research contribution in the topics: Population & Carbonic anhydrase. The organization has 27292 authors who have published 79599 publications receiving 2341684 citations. The organization is also known as: Università degli studi di Firenze & Universita degli studi di Firenze.

Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.

Abstract: Kawasaki disease is a systemic vasculitis of unknown etiology, with clinical observations suggesting a substantial genetic contribution to disease susceptibility. We conducted a genome-wide association study and replication analysis in 2,173 individuals with Kawasaki disease and 9,383 controls from five independent sample collections. Two loci exceeded the formal threshold for genome-wide significance. The first locus is a functional polymorphism in the IgG receptor gene FCGR2A (encoding an H131R substitution) (rs1801274; P = 7.35 × 10(-11), odds ratio (OR) = 1.32), with the A allele (coding for histadine) conferring elevated disease risk. The second locus is at 19q13, (P = 2.51 × 10(-9), OR = 1.42 for the rs2233152 SNP near MIA and RAB4B; P = 1.68 × 10(-12), OR = 1.52 for rs28493229 in ITPKC), which confirms previous findings(1). The involvement of the FCGR2A locus may have implications for understanding immune activation in Kawasaki disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease.

Friendship and loneliness among bullies and victims: Data from seven countries

Abstract: Research suggests that the relationship between school bullying and its various risk factors should be clearer among girls than boys, and should become stronger with age, as roles within the peer group stabilise. This paper tests this theory by comparing sex, school type, and bully/victim status differences in friendships and playground social interactions, using data from nine surveys in seven countries: China, England, Ireland, Italy, Japan, Portugal, and Spain. A total of approximately 48,000 children completed various translations of the Olweus Bullying Questionnaire. Small but generally consistent main effects were found for sex and school type (boys and primary pupils enjoyed playtimes more and had more friends, but were also more likely to spend playtimes alone). Larger effects were consistently found for bully/victim status (victims were significantly worse off on all the measures in all the samples where a difference was found, while bullies and neutrals did not differ consistently), but the interactions between these factors varied widely between samples and there were few consistent patterns. It is concluded that bullying is a universal phenomenon with many negative correlates for victims and few (if any) for bullies, but that there are cultural variations in the way that bullying is related to sex, age, and social support.

Social Capital and Local Development

Abstract: The concept of social capital has become more important in understanding contemporary economic development in the era of globalization. This concept, however, requires a theoretical framework that ...