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Showing papers by "University of Huddersfield published in 2018"


Journal ArticleDOI
24 Dec 2018
TL;DR: This paper conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings, and found that very little heterogeneity was attributable to the order in which the tasks were performed or whether the task were administered in lab versus online.
Abstract: We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance (p < .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion (p < .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely high-powered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small (< 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.

495 citations


Journal ArticleDOI
TL;DR: In this article, the prediction power of the economic policy uncertainty (EPU) index on the daily Bitcoin returns was analyzed using the Bayesian Graphical Structural Vector Autoregressive model as well as the Ordinary Least Squares and the Quantile-on-Quantile Regression estimations.

453 citations


Journal ArticleDOI
15 Jun 2018-Energy
TL;DR: In this article, the authors introduced a growth model that considers the indicator of economic complexity as a measure of capabilities for exporting the high value-added (sophisticated) products.

279 citations


Journal ArticleDOI
TL;DR: Meta-analytic estimates of the relationships, as determined by a correlation coefficient, between internal and external measures of load and intensity during team-sport training and competition are provided.
Abstract: The associations between internal and external measures of training load and intensity are important in understanding the training process and the validity of specific internal measures. We aimed to provide meta-analytic estimates of the relationships, as determined by a correlation coefficient, between internal and external measures of load and intensity during team-sport training and competition. A further aim was to examine the moderating effects of training mode on these relationships. We searched six electronic databases (Scopus, Web of Science, PubMed, MEDLINE, SPORTDiscus, CINAHL) for original research articles published up to September 2017. A Boolean search phrase was created to include search terms relevant to team-sport athletes (population; 37 keywords), internal load (dependent variable; 35 keywords), and external load (independent variable; 81 keywords). Articles were considered for meta-analysis when a correlation coefficient describing the association between at least one internal and one external measure of session load or intensity, measured in the time or frequency domain, was obtained from team-sport athletes during normal training or match-play (i.e., unstructured observational study). The final data sample included 122 estimates from 13 independent studies describing 15 unique relationships between three internal and nine external measures of load and intensity. This sample included 295 athletes and 10,418 individual session observations. Internal measures were session ratings of perceived exertion (sRPE), sRPE training load (sRPE-TL), and heart-rate-derived training impulse (TRIMP). External measures were total distance (TD), the distance covered at high and very high speeds (HSRD ≥ 13.1–15.0 km h−1 and VHSRD ≥ 16.9–19.8 km h−1, respectively), accelerometer load (AL), and the number of sustained impacts (Impacts > 2–5 G). Distinct training modes were identified as either mixed (reference condition), skills, metabolic, or neuromuscular. Separate random effects meta-analyses were conducted for each dataset (n = 15) to determine the pooled relationships between internal and external measures of load and intensity. The moderating effects of training mode were examined using random-effects meta-regression for datasets with at least ten estimates (n = 4). Magnitude-based inferences were used to interpret analyses outcomes. During all training modes combined, the external load relationships for sRPE-TL were possibly very large with TD [r = 0.79; 90% confidence interval (CI) 0.74 to 0.83], possibly large with AL (r = 0.63; 90% CI 0.54 to 0.70) and Impacts (r = 0.57; 90% CI 0.47 to 0.64), and likely moderate with HSRD (r = 0.47; 90% CI 0.32 to 0.59). The relationship between TRIMP and AL was possibly large (r = 0.54; 90% CI 0.40 to 0.66). All other relationships were unclear or not possible to infer (r range 0.17–0.74, n = 10 datasets). Between-estimate heterogeneity [standard deviations (SDs) representing unexplained variation; τ] in the pooled internal–external relationships were trivial to extremely large for sRPE (τ range = 0.00–0.47), small to large for sRPE-TL (τ range = 0.07–0.31), and trivial to moderate for TRIMP (τ range= 0.00–0.17). The internal–external load relationships during mixed training were possibly very large for sRPE-TL with TD (r = 0.82; 90% CI 0.75 to 0.87) and AL (r = 0.81; 90% CI 0.74 to 0.86), and TRIMP with AL (r = 0.72; 90% CI 0.55 to 0.84), and possibly large for sRPE-TL with HSRD (r = 0.65; 90% CI 0.44 to 0.80). A reduction in these correlation magnitudes was evident for all other training modes (range of the change in r when compared with mixed training − 0.08 to − 0.58), with these differences being unclear to possibly large. Training mode explained 24–100% of the between-estimate variance in the internal–external load relationships. Measures of internal load derived from perceived exertion and heart rate show consistently positive associations with running- and accelerometer-derived external loads and intensity during team-sport training and competition, but the magnitude and uncertainty of these relationships are measure and training mode dependent.

244 citations


Journal ArticleDOI
TL;DR: In this article, an assessment model is developed for Industry 4.0, which is based on an assessment of the complex characteristics of Industry 5.0 and as a result is uncertain about what it represents for them.
Abstract: Firms do not currently fully appreciate the complex characteristics of Industry 4.0 and as a result are uncertain about what it represents for them. In this study, an assessment model is developed ...

214 citations


Journal ArticleDOI
TL;DR: A new fault detection algorithm for photovoltaic (PV) systems based on artificial neural networks (ANN) and fuzzy logic system interface and both Mamdani, Sugeno fuzzy logic systems interface is proposed.

167 citations


Journal ArticleDOI
TL;DR: In this paper, the authors present an in-depth case study detailing the history, experiences, and wider practitioner and policy lessons from a circular economy business model over a 30-year period.
Abstract: This article presents an in-depth case study detailing the history, experiences, and wider practitioner and policy lessons from a circular economy business model over a 30-year period, highlighting

164 citations


Journal ArticleDOI
TL;DR: A systematic review of Web of Science, Pubmed and SPORTDiscus databases was performed, providing valuable information on the complex relationship between technical, tactical and physiological interactions in SSGs and how the manipulation of these types of variables can improve the soccer training process.
Abstract: The purpose of this paper was to systematically review and organise the literature on soccer SSGs, in order to ascertain the most frequently researched topics, characterise the methodologies employ...

156 citations


Journal ArticleDOI
TL;DR: In this paper, the authors investigated whether and to what extent publicly listed corporations voluntarily comply with and disclose recommended good corporate governance practices, and distinctively examined whether the observed cross-sectional differences in such CG disclosures can be explained by ownership and board mechanisms with specific focus on Saudi Arabia.
Abstract: This study investigates whether and to what extent publicly listed corporations voluntarily comply with and disclose recommended good corporate governance (CG) practices, and distinctively examines whether the observed cross-sectional differences in such CG disclosures can be explained by ownership and board mechanisms with specific focus on Saudi Arabia. The study’s results suggest that corporations with larger boards, a Big 4 auditor, higher government ownership, a CG committee, and higher institutional ownership disclose considerably more than those that are not. By contrast, the study finds that an increase in block ownership significantly reduces CG disclosure. The study’s results are generally robust to a number of econometric models that control for different types of disclosure indices, firm-specific characteristics, and firm-level fixed effects. The study’s results have important implications for policy makers, practitioners, and regulatory authorities, especially those in developing countries ac...

150 citations


Journal ArticleDOI
23 Nov 2018-Sensors
TL;DR: The principles of a number of energy harvesting technologies applicable to industrial machines are overviews by investigating the power consumption of WSNs and the potential energy sources in mechanical systems.
Abstract: Condition monitoring can reduce machine breakdown losses, increase productivity and operation safety, and therefore deliver significant benefits to many industries. The emergence of wireless sensor networks (WSNs) with smart processing ability play an ever-growing role in online condition monitoring of machines. WSNs are cost-effective networking systems for machine condition monitoring. It avoids cable usage and eases system deployment in industry, which leads to significant savings. Powering the nodes is one of the major challenges for a true WSN system, especially when positioned at inaccessible or dangerous locations and in harsh environments. Promising energy harvesting technologies have attracted the attention of engineers because they convert microwatt or milliwatt level power from the environment to implement maintenance-free machine condition monitoring systems with WSNs. The motivation of this review is to investigate the energy sources, stimulate the application of energy harvesting based WSNs, and evaluate the improvement of energy harvesting systems for mechanical condition monitoring. This paper overviews the principles of a number of energy harvesting technologies applicable to industrial machines by investigating the power consumption of WSNs and the potential energy sources in mechanical systems. Many models or prototypes with different features are reviewed, especially in the mechanical field. Energy harvesting technologies are evaluated for further development according to the comparison of their advantages and disadvantages. Finally, a discussion of the challenges and potential future research of energy harvesting systems powering WSNs for machine condition monitoring is made.

147 citations


Journal ArticleDOI
TL;DR: In this paper, the authors apply different techniques and uncover the quantile conditional dependence between the global financial stress index and Bitcoin returns from July 18, 2010, to December 29, 2017.

Journal ArticleDOI
TL;DR: This work develops a semantic and theoretical framework and proposes a new system for organizing and designating multiscale analyses and characterizations of surface topographies from the engineering and scientific literature with an emphasis on production engineering research and design.
Abstract: This work studies multiscale analyses and characterizations of surface topographies from the engineering and scientific literature with an emphasis on production engineering research and design It highlights methods that provide strong correlations between topographies and performance or topographies and processes, and methods that can confidently discriminate topographies that were processed or that perform differently These methods have commonalities in geometric characterizations at certain scales, which are observable with statistics and measurements It also develops a semantic and theoretical framework and proposes a new system for organizing and designating multiscale analyses Finally, future possibilities for multiscale analyses are discussed

Journal ArticleDOI
TL;DR: In this paper, the authors evaluate the adoption of lean thinking in the highways construction sector by investigating seven motivation factors, 20 lean techniques and 16 barriers through in-depth interviews with 20 sector managers and a questionnaire survey of 110 responses.
Abstract: The interest in lean thinking in the UK’s civil construction industry is on the rise. The research presented in the paper evaluates the adoption of lean thinking in the highways construction sector by investigating 7 motivation factors, 20 lean techniques and 16 barriers through in-depth interviews with 20 sector managers and a questionnaire survey of 110 responses. The findings show the existence of strong external motivational factors for lean thinking such as clients’ push and companies’ expectation of winning more contracts alongside lean’s operational benefits. Limited adoptions of the lean techniques, mostly in the stepwise process improvement cycle, the Last Planner System and Visual Management, were determined. This raises concerns about ‘pseudo-lean’ practices in the sector. Lack of standardisation, insufficient benefit capturing, insufficient know-how, insufficient control of the entire value stream and limited view to the techniques were found as the top barriers.

Journal ArticleDOI
TL;DR: The effect on poverty gap and poverty severity is, nevertheless, significant for both rural and urban areas with higher impact in the urban areas.
Abstract: The aim of this article is to investigate the claim that tourism development can be the engine for poverty reduction in Kenya using a dynamic, microsimulation computable general equilibrium model. The article improves on the common practice in the literature by using the more comprehensive Foster-Greer-Thorbecke (FGT) index to measure poverty instead of headcount ratios only. Simulations results from previous studies confirm that expansion of the tourism industry will benefit different sectors unevenly and will only marginally improve poverty headcount. This is mainly due to the contraction of the agricultural sector caused the appreciation of the real exchange rates. This article demonstrates that the effect on poverty gap and poverty severity is, nevertheless, significant for both rural and urban areas with higher impact in the urban areas. Tourism expansion enables poorer households to move closer to the poverty line. It is concluded that the tourism industry is pro-poor.

Journal ArticleDOI
TL;DR: A computational intelligence method called Variable Analysis (Va) is proposed that considers feature-to-class correlations and reduces feature- to-feature correlations and was able to derive fewer numbers of features from adult, adolescent, and child screening methods yet maintained competitive predictive accuracy, sensitivity, and specificity rates.

Journal ArticleDOI
TL;DR: This Concept concerns the bio-available solvent Cyrene (dihydrolevoglucosenone) as a potential replacement for toxic dipolar aprotic solvents.
Abstract: The development of green solvents is one of the key tenets of Green Chemistry as solvents account for the majority of waste stemming from the production of the chemicals on which we have all come to rely. An important class of solvents is the dipolar aprotics, which include N,N-dimethylformamide (DMF) and N-methyl-2-pyrrolidone (NMP). In addition to being derived from non-renewable resources, these solvents are also under increased regulatory pressures that will limit their industrial applications. This Concept concerns the bio-available solvent Cyrene (dihydrolevoglucosenone) as a potential replacement for toxic dipolar aprotic solvents. An emphasis is placed on examining the strengths and weaknesses of Cyrene as a solvent and is accomplished by looking at the synthesis, derivatization, and application in synthetic protocols of Cyrene. With respect to the Twelve Principles of Green Chemistry, this Concept describes a bio-available solvent that should have a disruptive effect on the use of traditional industrial dipolar aprotic solvents.

Journal ArticleDOI
TL;DR: In this article, the authors analyzed the determinants of the price of gold with a special focus on four uncertainty measures (namely, the volatility (VIX), skewness (SKEW), global economic policy uncertainty (EPU), and partisan conflict (PC) indexes).

Journal ArticleDOI
TL;DR: Although tolerancing is a mature field, new manufacturing processes and design methodologies are creating new avenues of research, and modelling standards must also evolve to support these processes.
Abstract: Variability is unavoidable in the realization of products. While design must specify ideal geometry, it shall also describe limits of variability (tolerances) that must be met in order to maintain proper product function. Although tolerancing is a mature field, new manufacturing processes and design methodologies are creating new avenues of research, and modelling standards must also evolve to support these processes. In addition, the study of uncertainty has produced widely-accepted methods of quantifying variability, and modern tolerancing tools should support these methods. The challenges introduced by new processes and design methodologies continue to make tolerancing research a fertile and productive area.


Journal ArticleDOI
TL;DR: A meta‐analysis of fMRI studies investigating the neural basis of RPE points to a sequential and distributed encoding of different components of the RPE signal, with potentially distinct functional roles.
Abstract: Learning occurs when an outcome differs from expectations, generating a reward prediction error signal (RPE). The RPE signal has been hypothesized to simultaneously embody the valence of an outcome (better or worse than expected) and its surprise (how far from expectations). Nonetheless, growing evidence suggests that separate representations of the two RPE components exist in the human brain. Meta-analyses provide an opportunity to test this hypothesis and directly probe the extent to which the valence and surprise of the error signal are encoded in separate or overlapping networks. We carried out several meta-analyses on a large set of fMRI studies investigating the neural basis of RPE, locked at decision outcome. We identified two valence learning systems by pooling studies searching for differential neural activity in response to categorical positive-versus-negative outcomes. The first valence network (negative > positive) involved areas regulating alertness and switching behaviours such as the midcingulate cortex, the thalamus and the dorsolateral prefrontal cortex whereas the second valence network (positive > negative) encompassed regions of the human reward circuitry such as the ventral striatum and the ventromedial prefrontal cortex. We also found evidence of a largely distinct surprise-encoding network including the anterior cingulate cortex, anterior insula and dorsal striatum. Together with recent animal and electrophysiological evidence this meta-analysis points to a sequential and distributed encoding of different components of the RPE signal, with potentially distinct functional roles.

Journal ArticleDOI
TL;DR: In this article, the effect of corporate board attributes, ownership structure and firm-level characteristics on both corporate mandatory and voluntary disclosure behavior was investigated, and the authors found that board size, board composition, frequency of board meetings and the presence of an audit committee have an impact on the level of corporate disclosure.
Abstract: Purpose The purpose of this paper is to investigate the effect of corporate board attributes, ownership structure and firm-level characteristics on both corporate mandatory and voluntary disclosure behaviour. Design/methodology/approach Multivariate regression techniques are used to estimate the effect of corporate board and ownership structures on mandatory and voluntary disclosures of a sample of Libyan listed and non-listed firms between 2006 and 2010. Findings First, the authors find that board size, board composition, the frequency of board meetings and the presence of an audit committee have an impact on the level of corporate disclosure. Second, results indicate that ownership structures have a non-linear effect on the level of corporate disclosure. Finally, the authors document that firm age, liquidity, listing status, industry type and auditor type are positively associated with the level of corporate disclosure. Research limitations/implications Future research could investigate disclosure practices using other channels of corporate disclosure media, such as corporate websites. Useful insights may be offered also by future studies by conducting in-depth interviews with corporate managers, directors and owners regarding these issues. Practical implications The evidence relating to the important role that corporate governance mechanisms play in shaping the expectations relating to the level of corporate voluntary and/or mandatory disclosures may be useful in informing investor decisions, as well as future policy and regulatory initiatives. Originality/value This paper contributes to the existing literature by examining the governance-disclosure nexus relating to both mandatory and voluntary disclosures in both listed and non-listed firms operating in a developing country setting.

Journal ArticleDOI
TL;DR: In this paper, a new hybrid model integrated adaptive neuro fuzzy inference system with Firefly Optimization algorithm (ANFIS-FFA), is proposed for forecasting monthly rainfall with one-month lead time.
Abstract: In this study, a new hybrid model integrated adaptive neuro fuzzy inference system with Firefly Optimization algorithm (ANFIS-FFA), is proposed for forecasting monthly rainfall with one-month lead time. The proposed ANFIS-FFA model is compared with standard ANFIS model, achieved using predictor-predictand data from the Pahang river catchment located in the Malaysian Peninsular. To develop the predictive models, a total of fifteen years of data were selected, split into nine years for training and six years for testing the accuracy of the proposed ANFIS-FFA model. To attain optimal models, several input combinations of antecedents’ rainfall data were used as predictor variables with sixteen different model combination considered for rainfall prediction. The performances of ANFIS-FFA models were evaluated using five statistical indices: the coefficient of determination (R 2 ), Nash-Sutcliffe efficiency (NSE), Willmott’s Index (WI), root mean square error (RMSE) and mean absolute error (MAE). The results attained show that, the ANFIS-FFA model performed better than the standard ANFIS model, with high values of R 2 , NSE and WI and low values of RMSE and MAE. In test phase, the monthly rainfall predictions using ANFIS-FFA yielded R 2 , NSE and WI of about 0.999, 0.998 and 0.999, respectively, while the RMSE and MAE values were found to be about 0.272 mm and 0.133 mm, respectively. It was also evident that the performances of the ANFIS-FFA and ANFIS models were very much governed by the input data size where the ANFIS-FFA model resulted in an increase in the value of R 2 , NSE and WI from 0.463, 0.207 and 0.548, using only one antecedent month of data as an input (t-1), to almost 0.999, 0.998 and 0.999, respectively, using five antecedent months of predictor data (t-1, t-2, t-3, t-6, t-12, t-24). We ascertain that the ANFIS-FFA is a prudent modelling approach that could be adopted for the simulation of monthly rainfall in the present study region.

Journal ArticleDOI
TL;DR: It is suggested that bike-sharing can go beyond, what is typically regarded as its primary function, that of a last-mile solution for metropolitan areas, and be a publicly acceptable investment for smaller cities.
Abstract: Developing initiatives that allow societies to embrace more sustainable travel behaviour patterns is a prerequisite for creating more livable urban futures. Bike-sharing, a measure designed to inspire modal shift from short car-trips, despite its recent exponential growth, is still understudied. This paper discusses a quantitative survey of 640 responses examining road users' attitudes towards bike-sharing and its possible introduction to Drama, a small Greek city resembling many others in terms of size, transport culture and socio-economic characteristics, which has never been exposed to a similar intervention. Most of the respondents recognised that bike-sharing is a mode with pro-environmental, cost-effective and health-improving qualities and the potential to promote a greener identity for the city. Evidence is provided that people would support a bike-sharing investment even in cases where the frequency of their current bicycle use and the regularity with which they intend to use an eventual scheme is low. Age, gender, the primary factor for modal choice, its perceived effectiveness in reducing traffic congestion and their usage expectations were all factors influencing the respondents’ acceptability of such an introduction. The lack of cycling infrastructure and road safety concerns were identified as possible usage barriers but the pro-social potential of bike-sharing combined with policy efforts to create a more pro-cycling culture could outweigh them. The present analysis suggests that bike-sharing can go beyond, what is typically regarded as its primary function, that of a last-mile solution for metropolitan areas, and be a publicly acceptable investment for smaller cities.

Journal ArticleDOI
TL;DR: In this article, the authors reviewed recent progress in the field regarding the production of bio-fertiliser from food waste, using anaerobic digestion, aerobic composting, chemical hydrolysis, in situ degradation and direct burning methods.

Journal ArticleDOI
TL;DR: In this article, a wideband piezoelectric vibration energy harvester with a quadruple-well potential induced by the combined nonlinearity of cantilever-surface contact and magnetoelasticity is proposed.

Journal ArticleDOI
TL;DR: In this article, the authors focus on the relationship between economic inequality and out-of-home care and child protection interventions and show that there is a strong relationship between deprivation and intervention rates and large inequalities between ethnic categories.
Abstract: The role that area deprivation, family poverty, and austerity policies play in the demand for and supply of children's services has been a contested issue in England in recent years. These relationships have begun to be explored through the concept of inequalities in child welfare, in parallel to the established fields of inequalities in education and health. This article focuses on the relationship between economic inequality and out-of-home care and child protection interventions. The work scales up a pilot study in the West Midlands to an all-England sample, representative of English regions and different levels of deprivation at a local authority (LA) level. The analysis evidences a strong relationship between deprivation and intervention rates and large inequalities between ethnic categories. There is further evidence of the inverse intervention law (Bywaters et al., 2015): For any given level of neighbourhood deprivation, higher rates of child welfare interventions are found in LAs that are less deprived overall. These patterns are taking place in the context of cuts in spending on English children's services between 2010–2011 and 2014–2015 that have been greatest in more deprived LAs. Implications for policy and practice to reduce such inequalities are suggested.

Journal ArticleDOI
TL;DR: Owing to its low cost and versatility, this approach can be adapted to wide spectrum of liquid formulations such as small and large molecule solutions and obviate the need for compatibility with the high temperature of FDM 3D printing process.

Journal ArticleDOI
TL;DR: A comprehensive review of negatively photochromic switches can be found in this paper, where the authors examine the dark side of photochromism, namely the ability of these molecules to undergo structural and electronic reorganisation which has been seized upon by materials scientists for the development of switches, logic gates, photoinduced molecular motions such as rotors and fibrils, and photoregulation of drug availability.

Journal ArticleDOI
TL;DR: The findings illustrate that the environmental Kuznets curve (EKC) hypothesis is valid in the panel dataset of 19 developed economies and documents that a higher level of the product concentration of exports leads to lower CO2 emissions.
Abstract: This paper provides the evidence on the short- and the long-run effects of the export product concentration on the level of CO2 emissions in 19 developed (high-income) economies, spanning the period 1962-2010. To this end, the paper makes use of the nonlinear panel unit root and cointegration tests with multiple endogenous structural breaks. It also considers the mean group estimations, the autoregressive distributed lag model, and the panel quantile regression estimations. The findings illustrate that the environmental Kuznets curve (EKC) hypothesis is valid in the panel dataset of 19 developed economies. In addition, it documents that a higher level of the product concentration of exports leads to lower CO2 emissions. The results from the panel quantile regressions also indicate that the effect of the export product concentration upon the per capita CO2 emissions is relatively high at the higher quantiles.

Journal ArticleDOI
TL;DR: This review collates the available information on benzodiazepines and provides a starting point for the further investigation of their pharmacokinetics which is clearly required.
Abstract: The market for new psychoactive substances has increased markedly in recent years and there is now a steady stream of compounds appearing every year. Benzodiazepines consist of only a fraction of the total number of these compounds but their use and misuse has rapidly increased. Some of these benzodiazepines have only been patented, some of them have not been previously synthesised, and the majority have never undergone clinical trials or tests. Despite their structural and chemical similarity, large differences exist between the benzodiazepines in their pharmacokinetic parameters and metabolic pathways and so they are not easily comparable. As benzodiazepines have been clinically used since the 1960s, many analytical methods exist to quantify them in a variety of biological matrices and it is expected that these methods would also be suitable for the detection of benzodiazepines that are novel psychoactive substances. Illicitly obtained benzodiazepines have been found to contain a wide range of compounds such as opiates which presents a problem since the use of them in conjunction with each other can lead to respiratory depression and death. This review collates the available information on these benzodiazepines and provides a starting point for the further investigation of their pharmacokinetics which is clearly required.