University of Miami

About: University of Miami is a education organization based out in Coral Gables, Florida, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 47313 authors who have published 97760 publications receiving 4043520 citations. The organization is also known as: UM & U of M.

Robust Responses of the Hydrological Cycle to Global Warming

Abstract: Using the climate change experiments generated for the Fourth Assessment of the Intergovernmental Panel on Climate Change, this study examines some aspects of the changes in the hydrological cycle that are robust across the models. These responses include the decrease in convective mass fluxes, the increase in horizontal moisture transport, the associated enhancement of the pattern of evaporation minus precipitation and its temporal variance, and the decrease in the horizontal sensible heat transport in the extratropics. A surprising finding is that a robust decrease in extratropical sensible heat transport is found only in the equilibrium climate response, as estimated in slab ocean responses to the doubling of CO2, and not in transient climate change scenarios. All of these robust responses are consequences of the increase in lower-tropospheric water vapor.

The Relative Performance of Full Information Maximum Likelihood Estimation for Missing Data in Structural Equation Models

Abstract: A Monte Carlo simulation examined the performance of 4 missing data methods in structural equation models: full information maximum likelihood (FIML), listwise deletion, pairwise deletion, and similar response pattern imputation. The effects of 3 independent variables were examined (factor loading magnitude, sample size, and missing data rate) on 4 outcome measures: convergence failures, parameter estimate bias, parameter estimate efficiency, and model goodness of fit. Results indicated that FIML estimation was superior across all conditions of the design. Under ignorable missing data conditions (missing completely at random and missing at random), FIML estimates were unbiased and more efficient than the other methods. In addition, FIML yielded the lowest proportion of convergence failures and provided near-optimal Type 1 error rates across both simulations.

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Abstract: Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.