Institution
University of Naples Federico II
Education•Naples, Campania, Italy•
About: University of Naples Federico II is a education organization based out in Naples, Campania, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 29291 authors who have published 68803 publications receiving 1920149 citations. The organization is also known as: Università degli Studi di Napoli Federico II & Naples University.
Topics: Population, Cancer, Medicine, Context (language use), Computer science
Papers published on a yearly basis
Papers
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Katholieke Universiteit Leuven1, Imperial College London2, University College London3, Boston Children's Hospital4, Phillips University5, University of Groningen6, Innsbruck Medical University7, St George's, University of London8, Utrecht University9, University of Hamburg10, Erasmus University Rotterdam11, University of Parma12, University of Brescia13, University of Amsterdam14, University of Naples Federico II15, Technische Universität München16, University of Jena17, University of Turin18
TL;DR: The proportion of infants surviving without neuroimpairment was non-significant at the primary endpoint, and timing of delivery based on the study protocol using late changes in the DV waveform might produce an improvement in developmental outcomes at 2 years of age.
307 citations
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TL;DR: The aim of this review is to highlight the relationship between vitamin D and cancer, summarizing several mechanisms proposed to explain the potential protective effect of vitamin D against the development and progression of cancer.
Abstract: Vitamin D system is a complex pathway that includes precursors, active metabolites, enzymes and receptors activating several molecular pathways and mediating a multitude of functions. In addition to the classical role of vitamin D metabolites in calcium and bone homeostasis, many in vitro and in vivo studies recognized several "non calcemic" effects involved in host defence, inflammation, immunity and cancer processes. The aim of this review is to highlight the relationship between vitamin D and cancer, summarizing several mechanisms proposed to explain the potential protective effect of vitamin D against the development and progression of cancer. Vitamin D acts like a transcription factor that influences central mechanisms of tumorigenesis: growth, cell differentiation and apoptosis. In addition to cellular and molecular studies, epidemiological surveys have shown that sunlight exposure and consequent increased circulating levels of vitamin D are associated not only with reduced occurrence but also with reduced mortality for different histological types of cancer. Another recent field of interest concerns polymorphisms of vitamin D receptor: in this context, preliminary data suggest that vitamin D receptor polymorphisms more frequently associated with tumorigenesis are Fok1, Bsm1, Taq1, Apa1, EcoRV, Cdx2, although further studies are needed to clarify any discrepancies. In this review, the relationship between vitamin D and cancer is discussed.
307 citations
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TL;DR: The alignment of the three APP encoding cDNA fragments found in the screening suggests that the region of APP involved in the binding is centered on the NPTY sequence, which is analogous to that present in the intracellular domains of the growth factor receptors interacting with the PID/PTB domain of Shc.
306 citations
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TL;DR: The long-term follow-up data on the 5-patient Italian cohort involved in the LCA2 gene therapy clinical trial clearly showed a stability of improvement in visual and retinal function that had been achieved a few months after treatment.
306 citations
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TL;DR: In this article, the observed significance is 5.8 standard deviations, compared to an expectation of 4.9 standard deviations and the observed (expected) significance is 6.3 (5.1) standard deviations.
306 citations
Authors
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Name | H-index | Papers | Citations |
---|---|---|---|
D. M. Strom | 176 | 3167 | 194314 |
Yang Gao | 168 | 2047 | 146301 |
Robert Stone | 160 | 1756 | 167901 |
Elio Riboli | 158 | 1136 | 110499 |
Barry J. Maron | 155 | 792 | 91595 |
H. Eugene Stanley | 154 | 1190 | 122321 |
Paul Elliott | 153 | 773 | 103839 |
Robert O. Bonow | 149 | 808 | 114836 |
Kai Simons | 147 | 426 | 93178 |
Peter Buchholz | 143 | 1181 | 92101 |
Martino Margoni | 141 | 2059 | 107829 |
H. A. Neal | 141 | 1903 | 115480 |
Luca Lista | 140 | 2044 | 110645 |
Pierluigi Paolucci | 138 | 1965 | 105050 |
Ari Helenius | 137 | 298 | 64789 |