Institution
University of Naples Federico II
Education•Naples, Campania, Italy•
About: University of Naples Federico II is a education organization based out in Naples, Campania, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 29291 authors who have published 68803 publications receiving 1920149 citations. The organization is also known as: Università degli Studi di Napoli Federico II & Naples University.
Topics: Population, Cancer, Medicine, Context (language use), Computer science
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that hearing aids may protect against cognitive impairment and disability, improving quality of life of aged people and the use of hearing aids reduced GDS score.
Abstract: Background: Hearing impairment (HI) is a very common condition in elderly people and the epidemiology together with hearing-related problems is still poorly investigated. Moreover,
252 citations
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TL;DR: ACP gel significantly reduces the development of intrauterine adhesion postoperatively and its use is likely to be associated with a reduction of severe adhesions.
Abstract: BACKGROUND: A prospective, randomized, controlled study was performed to assess the efficacy of auto-crosslinked hyaluronic acid (ACP) gel to prevent the development of de-novo intrauterine adhesions following hysteroscopic surgery. METHODS: One hundred and thirty-two patients with a single surgically remediable intrauterine lesion (myomas, polyps and uterine septa, subgroups I-III) completed the study. Patients were randomized to two different groups: group A underwent hysteroscopic surgery plus intrauterine application of ACP gel (10 ml) while group B underwent hysteroscopic surgery alone (control group). The rate of adhesion formation and the adhesion score was calculated for each group and subgroup 3 months after surgery. RESULTS: Group A showed a significant reduction in the development of de-novo intrauterine adhesions at 3 months follow-up in comparison with the control group. Furthermore, the staging of adhesions showed a significant decrease in adhesion severity in patients treated with ACP gel. CONCLUSIONS: ACP gel significantly reduces the incidence and severity of de-novo formation of intrauterine adhesions after hysteroscopic surgery.
252 citations
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TL;DR: Gastroenteritis caused by enterotoxigenic E. coli and shigella resistant to a number of drugs was a major problem that frequently interfered with the duties of U.S. troops during Operation Desert Shield.
Abstract: Background. Under combat conditions infectious disease can become a major threat to military forces. During Operation Desert Shield, there were numerous outbreaks of diarrhea among the U.S. forces. To evaluate the causes of and risk factors for diarrheal disease, we collected clinical and epidemiologic data from U.S. troops stationed in northeastern Saudi Arabia. Methods. 432 military personnel who presented with diarrhea, cramps, vomiting, or hematochezia. In addition, a questionnaire was administered to 2022 soldiers in U.S. military units located in various regions of Saudi Arabia. Results. A bacterial enteric pathogen was identified in 49.5 percent of the troops with gastroenteritis. Enterotoxigenic Escherichia coli and Shigella sonnei were the most common bacterial pathogens. Of 125 E. coli infections, 39 percent were resistant to trimethoprim–sulfamethoxazole, 63 percent to tetracycline, and 48 percent to ampicillin. Of 113 shigella infections, 85 percent were resistant to trimethoprim–sulf...
252 citations
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TL;DR: The effectiveness of cabergoline in normalizing cortisol secretion in 40% of cases supports its therapeutic use in the management of Cushing's disease and in conclusion, functional D(2) receptors were expressed in approximately 80% of corticotroph pituitary tumors.
Abstract: The role of dopamine agonist treatment in corticotroph pituitary tumors is
controversial. The aim of this study was to evaluate D(2) receptor
expression in 20 corticotroph pituitary tumors and to correlate it to the
in vitro effect of dopamine agonists on ACTH secretion and the in vivo
effect of short-term cabergoline treatment on cortisol secretion. D(2)
expression was evaluated by receptor-ligand binding, immunohistochemistry,
and RT-PCR. A 50% or more decrease in daily urinary cortisol levels was
considered a significant clinical response. At receptor-ligand binding,
specific binding of [(125)I]epidepride was found in 80% of cases. At
immunohistochemistry, specific D(2) immunostaining was found in 75% of
cases. D(2) expression was found in 83.3% of cases (D(2long) in 40%,
D(2short) in 20%, and both in 40%) by RT-PCR. Significant in vitro
inhibition of ACTH secretion was found in 100% of D(2)-positive cases, but
not in 100% of D(2)-negative cases by either bromocriptine or cabergoline.
A significant in vivo inhibition of cortisol secretion after 3-month
cabergoline treatment was found in 60%, although a normalization of
cortisol secretion was found in 40% of cases. All cabergoline-responsive
cases were associated with D(2) expression, whereas all
noncabergoline-responsive cases but one were not associated with D(2)
expression. In conclusion, functional D(2) receptors were expressed in
approximately 80% of corticotroph pituitary tumors. The effectiveness of
cabergoline in normalizing cortisol secretion in 40% of cases supports its
therapeutic use in the management of Cushing's disease.
251 citations
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TL;DR: The data suggest that cardiac remodeling associated with HCM determines a significant release of miRNAs into the bloodstream: the circulating levels of both cardiac- and non-cardiac-specific miRNas are significantly increased in the plasma of HCM patients.
251 citations
Authors
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Name | H-index | Papers | Citations |
---|---|---|---|
D. M. Strom | 176 | 3167 | 194314 |
Yang Gao | 168 | 2047 | 146301 |
Robert Stone | 160 | 1756 | 167901 |
Elio Riboli | 158 | 1136 | 110499 |
Barry J. Maron | 155 | 792 | 91595 |
H. Eugene Stanley | 154 | 1190 | 122321 |
Paul Elliott | 153 | 773 | 103839 |
Robert O. Bonow | 149 | 808 | 114836 |
Kai Simons | 147 | 426 | 93178 |
Peter Buchholz | 143 | 1181 | 92101 |
Martino Margoni | 141 | 2059 | 107829 |
H. A. Neal | 141 | 1903 | 115480 |
Luca Lista | 140 | 2044 | 110645 |
Pierluigi Paolucci | 138 | 1965 | 105050 |
Ari Helenius | 137 | 298 | 64789 |